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Biomedical subjects

A Valach

Publications and source records attributed to A Valach.

14 recordsLinked to original sources
PubMed1990

[Transplacental transfer, tissue localization and morphological study of the rabbit placenta after the administration of pentacaine].

On day 29 of gravidity, the New Zealand white breed rabbits were intravenously administered 3H-pentacaine (0.5 mg.kg-1), a new local anaesthetic agent with anti-ulcerous effect in order to study the distribution in pregnant females. Transplacental passage and a relatively homogenous distribution of unchanged pentacaine were found in the organs of females with the largest accumulation in the lungs. Pentacaine is distributed in the same manner in the fetal organs as in the organs of the mother, but the levels in the foetuses were significantly lower. A morphological study of the rabbit placenta on day 29 of gravidity after the doses of 1, 10 and 50 mg.kg-1 of pentacaine did not show any pathological changes.

Anesthetics, Local↗
PubMed1988

Endoscopic gastroduodenal polypectomy.

The authors performed a total of 288 successful endoscopic gastroduodenal polypectomy procedures in 129 patients. Drawing on literary data and the results of follow-up of their own patients, they regard endoscopic gastroduodenal polypectomy as a successful and relatively low-risk method for secondary prevention of gastric cancer. Recurrence of adenomas, with malignant degeneration in 6-75%, was noted, only in the first year after primary polypectomy, in 8% of patients. Four percent of patients after adenoma polypectomy developed gastric carcinoma. Removal of gastroduodenal adenomas by endoscopy represents a final therapeutic procedure significantly reducing the possibility of these originally benign variants transforming into malignant ones. Even polyps smaller than 10 mm in diameter may be adenomas possessing a rather high malignant potential. The authors regard endoscopic polypectomy of hyperplastic polyps as a justified procedure since the literary data compiled and their own experience suggest polyp susceptibility to development of dysplasia. While this tendency gets manifest only rarely, it would be medically wrong to dismiss it as negligible. In case of removal of an early polypoid gastric carcinoma, endoscopic polypectomy is a therapeutic procedure only in clearly defined and histologically well classified cases. In other cases involving prominence of the gastroduodenal mucosa, it is an invaluable diagnostic method whose benefit is that it removes an entire polyp for histologic examination.

Adult↗
PubMed1985

Decreased apolipoprotein levels in women with hyperprolactinemia related to increased estradiol level: effect of hepatic lesion?

In 3 groups of women (1. with pathological hyperprolactinemia, but low estradiol level--19 patients; 2. with pathological hyperprolactinemia, but high estradiol level--17 patients; 3. 16 healthy control women) the level of prolactin, estradiol, cortisol, total cholesterol, triglycerides and apolipoproteins A-I, A-II and B in serum was estimated together with routine clinical examination. In both hyperprolactinemic groups a significant decrease of apolipoprotein A-I and A-II was found, while in the group with high estradiol also a significant decrease of apolipoprotein B was observed. It is suggested that the increased level of prolactin results in an impairment of apolipoprotein biosynthesis and, in addition, in a group with high estradiol level also a lesion of liver function might occur which results in its decreased degradation.

Apolipoprotein A-I↗
PubMed1985

Malignant tumors and embolizing paraneoplastic endocarditis.

A group of 4495 autopsied patients was evaluated. In 1011 (22.5%) of them various malignancies were found. In 20 of these cancer patients (2%) also a nonbacterial verrucous endocarditis was observed. The most serious complication of this paraneoplastic syndrome was central arterial embolization resulting in cerebral and myocardial infarctions. In our group this was observed in 12 patients (60%), in 9 cases of them infarction was the immediate cause of death. Fatal complications due to central embolization were seen also in 3 patients who had a malignant disease without symptoms of generalization. The most frequent tumors observed among the autopsied patients were adenocarcinomas of the digestive tract (40%). In the group of revealed tumors adenocarcinomas clearly prevailed (70%) in 10 cases (50%) also mucin production could be detected.

Adenocarcinoma↗