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A Valdivielso

Publications and source records attributed to A Valdivielso.

8 recordsLinked to original sources
PubMed1997

Non-tunneled catheters for the collection and transplantation of peripheral blood stem cells in children.

We analyzed the use of non-tunneled (polyurethane, double lumen) central venous catheters (CVCs) for the collection, conditioning, transplantation and immediate post-transplantation periods in 56 children with various malignant diseases. A total of 71 leukaphereses were performed, with a mean of 1.2 apheresis per patient, following administration of granulocyte colony-stimulating factor (G-CSF) using a continuous flow blood cell separator (Cobe Spectra). The mean TBV (total blood volume) processed was 4.5 +/- 1.2 s.d. (range 2.4-7). The mean flow rate was 30.6 ml/min and the duration of a single apheresis was 327 +/- 84 s.d. (range 175-511 min). The mean purities and efficacies of collections were 77.38 +/- s.d. (range 42-100) and 42.78 +/- s.d. (range 24-80), respectively. The mean numbers of mononuclear cells (MNC) and CD34+ cells collected were 9.3 +/- 6.9 s.d. x 10(8)/kg (range 2-49) and 6.2 +/- 7.2 s.d. x 10(6)/kg (range 1-42), respectively. We observed the following complications during catheter insertion for collection: pneumothorax (1.7%), mechanical dysfunction (3.5%) that resolved with thrombolytic therapy. Complications during conditioning, transplantation and immediate post-transplantation periods were entry site infection in five patients (8.92%), catheter-related infection in two (3.57%) and catheter-related sepsis in three (5.35%). Our results indicate that the collection of PBSC with non-tunneled catheters is safe, effective and dis associated with a low incidence of complications.

Adolescent↗
PubMed1996

Non-tunneled catheters in children undergoing bone marrow transplantation.

We analyzed the use of non-tunneled (polyurethane double lumen) central venous catheters (CVCs) in 62 children undergoing bone marrow transplantation. The catheters were inserted in the Critical Care Unit without surgery or general anesthesia. The complications were pneumothorax in two patients and hemopneumothorax in two other patients (6.06%), entry site infection in six patients (9.6%), catheter-related infection in eight patients (12.9%) and catheter-related sepsis in nine patients (14.5%). The catheters were removed upon completion of therapy in 46 patients (74.1%), death in seven patients (11.3%) and in nine cases (14.5%) for infection. Despite the complications specific to non-tunneled catheter insertion, we believe this is indicated for patients during conditioning, transplantation and immediate post-transplantation periods.

Adolescent↗
PubMed1988

[Total neutrophils and age as prognostic factors of meningococcal sepsis].

Meningococcal sepsis is a frequent disease in our population with a bad prognosis even in a few hours. The search for easy and fast to obtain criteria of severity is essential decrease in order to the mortality rates. We have studied in 56 patients ranged from two months to six years, with bacteriological confirmation of meningococcal sepsis, the clinical and analytical parameters at admission, in order to find those parameters with a better correlation with the severity of the process. Global mortality was 25%. Eleven out of 21 children (52%) with less than 2,000 neutrophils in peripheral blood at the time of admission died, while only three died in the 35 resting group (p less than 0.01). When it was associated with a small age, less than two years, mortality raised up to 60%. In our series, the prognosis based upon the total neutrophils at admission, can be compared with that obtained from the five parameters of severity from Sthiem-Samrosch, that take an hour to be obtained. Absolute neutrophil count and age, can be obtained at the time of admission assessing the severity of the disease in short time.

Age Factors↗
PubMed1984

[Naloxone and endotoxic shock: a wonder drug?].

Naloxone clorhidrate was administered intravenously to 15 patients with endotoxic shock and refractary hypotension, following meningococcal sepsis. Doses used were between 0.01-0.2 mg/kg. Three patients (two of them with moderate shock) showed an increase in sistolic arterial pressure, which was maintained and above 20 mm/Hg. Among the rest of them (except one with severe shock) naloxone action was non-existent in nine cases, or with short action and without answer to next doses in other three. Eleven patients died. A blood pressure increase was maintained only in two of the four survivors. Usefulness of naloxone in this kind of patients is not clear. Presence in endotoxin shock of a variety of refractory factors besides beta endorphins, greatly limits therapeutic efficiency of this drug.

Adolescent↗