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Biomedical subjects

A Velasco Oses

Publications and source records attributed to A Velasco Oses.

10 recordsLinked to original sources

Octreotide: effects in experimental severe acute pancreatitis. Analysis of survival, biochemical findings and histomorphometry.

OBJECTIVE: The effect of octreotide in acute experimental pancreatitis was examined. EXPERIMENTAL DESIGN: Acute pancreatitis was induced in 70 male Wistar rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. Octreotide (50 micrograms = 0.5 ml) or isotonic saline was administered subcutaneously every six hours for 24 hours, beginning at the time of induction of pancreatitis (groups 1 and 2) or 12 hours later (groups 3 and 4). Six hours after the last dose of octreotide or saline, the rats were sacrificed. Ten additional rats were used for basal biochemical determination. For the analysis of survival, another 10 rats were included. The survival rate, serum concentrations of amylase, lipase and lactate dehydrogenase (LDH) and morphometric studies (total area of the pancreas and percentage necrosis) were examined. Statistical analysis involved Student's t test, ANOVA and the Mantel-Haenszel test. RESULTS: No significant differences existed among the groups with respect to survival, morphometric analysis or biochemical determinations, except for a minor increase in LDH levels in the group treated with octreotide at the time of induction. CONCLUSIONS: Octreotide administration has almost no impact on mortality in experimental severe acute pancreatitis. Biochemical and morphometric changes are minimal. Therefore, according to the present study, the efficacy of octreotide administration is very low.

Acute Disease↗

[Leiomyosarcoma of the urinary bladder. A little frequent neoformation].

Presentation of one case of vesical wall leiomyosarcoma found during exploratory laparotomy due to abdominal pain, where partial cystectomy and lymphadenectomy were performed. Due to the singularity of this tumour, drafting of this clinical communication was undertaken including a brief review of the existing literature relative to the diagnosis and treatment of this neoformation.

Aged↗

[A case of leiomyosarcoma of the spermatic cord].

We report a case of leiomyosarcoma of the spermatic cord that we consider singular because of the excellent outcome. The patient is alive and tumor-free 8 years following the initial diagnosis. We discuss the management of these patients, a controversial subject since there are no definitive therapeutic guidelines because of the very limited series of patients.

Aged↗

[Inverted papilloma or inverted urothelial carcinoma. A problem not yet resolved in its totality. Contribution of two new cases to the literature].

We present two case of inverted vesical papillomas, one of a trabecular histology and the other glandular, which--in view of the appearance in the last few years of inverted papillomas coexisting alongside other urothelium tumorous states, recurring and even malignant inverted papillomas--raise the possibility of them being considered as superficial urothelium carcinomas. We propose the use of post-surgical endo-vesical chemotherapy, above all in the patients affected by the trabecular variety of inverted papillomas, due to their high indices of recurrence and high possibilities of malignancy.

Antineoplastic Agents↗

[Bagassosis. Allergic pneumonitis in an industrial employer (author's transl)].

A clinical observation of bagassosis in an industrial employer is reported. The disease had an acute initial onset with severe respiratory distress and roentgenographic image of pulmonary diffuse nodular infiltrates. Clinical manifestations and radiographic pattern disappeared after 4 months of corticosteroid therapy. Bagassosis is an allergic pneumonitis of hypersensitivity; other cases published up to the present time are reviewed as well as clinical symptoms, roentgenologic pattern, pathological findings and immunological origin corresponding to this condition. Bagassosis was first reported in 1937, it is an uncommon disease and its different forms of clinical presentation may lead to misdiagnosis. Cessation of exposure usually results in complete recovery.

Adrenal Cortex Hormones↗