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Biomedical subjects

A Verhaeghe

Publications and source records attributed to A Verhaeghe.

At least 19 recordsLinked to original sources
PubMed1996

Cutaneous cryptococcosis in corticosteroid-treated patients without AIDS.

Two corticosteroid-treated patients with cutaneous cryptococcal infection are described. One patient had pustulous lesions on the back of his left hand and cellulitis of his left forearm, the other patient had ulcerous lesions of the right forearm and cellulitis of the right lower leg. In both cases diagnosis was suggested by histopathological examination of a biopsy and confirmed by culture. One patient may have had disseminated cryptococcal disease as suggested by a positive cryptococcal capsular antigen test, the other had no evidence of dissemination. Treatment consisted of oral fluconazole for six weeks. One patient died of an unrelated cause after four weeks treatment. Secondary antifungal prophylaxis was not given. Cutaneous cryptococcal infections are described in AIDS patients, but only seldom observed in other immunocompromised patients. Early recognition of the cutaneous lesions is important, as they can be the first sign of disseminated cryptococcosis. Untreated, the mortality of this disease is high. Therapy consists of amphotericin B with or without flucytosine. Fluconazole may be valuable alternative. The optimal treatment regimen and duration are not defined yet. Contrary to AIDS patients with cryptococcal infection, who need life-long secondary antifungal prophylaxis in order to prevent relapses, suppressive treatment is not indicated for immunocompromised non-AIDS patients.

Aged↗
PubMed1994

Visual separability: a study on unschooled adults.

It has been suggested in previous studies that unschooled adults present serious difficulties at performing tasks which, like part verification, dimensional filtering, or orientation judgments, require them to pay attention to a specific aspect of the stimulus structure. In the present study we examined the performance of unschooled adults by using a task which does not explicitly require the subjects to attend selectively to a specific component of the stimuli. Separability either of parts or of dimensions as well as line-orientation registration were estimated by the occurrence of illusory conjunctions. Whatever the properties involved in the illusions, these occurred in unschooled adults, at about the same rate as in age-matched schooled controls. The two sets of contrasting findings suggest that a critical variable is whether or not the subjects' attentional control is required. The relevance of the present findings as regards the level of processing responsible for illusory conjunctions is discussed.

Aged↗
PubMed1992

[Iron deficiency in hospitalized infants: study of the incidence of the nutritional factor].

We report an investigation on the iron status of 209 hospitalized 3-month--2-year-old infants over a 6-month period. Hematological parameters and infant feeding practice were determined: a total of 105 infants (50.2%) were found to be iron-depleted, with (24.8%) or without (25.4%) anemia. The mode of lactation appeared to be the main determining factor in iron deficiency, as shown by the fact that during the first months, breast feeding and consumption of an iron-fortified milk formula were 50% less frequent and of shorter duration in infants with iron deficiency than in normal infants. Incorrect diet was also more frequent in iron-deficient infants. It is concluded that iron deficiency in infants could be prevented by better informing mothers in order to encourage breast-feeding and develop the use of an iron-fortified milk formula until the infant reaches the age of one year.

Anemia, Hypochromic↗
PubMed1992

[Malaria in the Dunkerque hospital center from December 1979 to December 1990].

Seventy-one cases of malaria were diagnosed in the hospital of Dunkerque from 1979 to 1990. Forty-five patients have been infected in the Comores islands. Among the 24 other imported cases, 17 (71%) have been contaminated in Western or Central Africa. One case of congenital malaria and one of malaria acquired by blood transfusion are also reported. Plasmodium falciparum was detected in 84.5% of the patients. The four human species were found among the Comorians. Two cases with abnormal forms of Plasmodium vivax were observed.

Adolescent↗
PubMed1991

[Atypical forms of Plasmodium vivax. Apropos of a case].

In one case of human malaria imported from Gabon, abnormal forms of Plasmodium vivax are described; severe multiple infections of the host erythrocytes are noticed (up to 6 amoeboid trophozoites in a single red blood cell). Attention is drawn to the numerous morphologically abnormal intra-erythrocytic stages of P. vivax: severe multiple infections of red cells, parasites "ressembling" P. ovale, mature schizonts of small size, with reduced number of merozoites... The geographical distribution of P. vivax in Central Africa is discussed, with reflections on the factors allowing the importation of few P. vivax cases from this area.

Adult↗
PubMed1984

[Preferential action of chloroquine on Plasmodium within mature erythrocytes].

In vitro studies on the effects of chloroquine on Plasmodium berghei in relation to the age of the host cell made it possible to demonstrate the preferential effect of the drug on parasites growing in mature red blood cells. The ED-50 for parasites in mature red blood cells is lower (1,64 +/- 0,2 mg/kg/day) than in reticulocytes (2,45 +/- 0,2 mg/kg/day). The result of clumping test for chloroquino-sensitive P. berghei growing in young red blood cells, is almost similar as in a chloroquino-resistant strain of the same species. These results are compared with physiological observations on Plasmodium host parasite relationships and bioclinical discrepancies noticed between in vivo chloroquine sensitivity of P. falciparum wild strains versus in vitro testing.

Animals↗
PubMed1978

Ultrasound by mouse pups from deaf and hearing strains.

Pups aged 1 to 10 days, of deaf and hearing mouse strains, were monitored with an ultrasound detector while submitted to standard conditions of cold, isolation, and retrieving. The number of detections varied with the age of the pups and with the type of treatment (as established previously) but not with the genotype of the pups. Thus, occurrence and changes with age in ultrasound emission do not seem to be greatly influenced by their effects upon adult behavior.

Aging↗