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Biomedical subjects

A Verity

Publications and source records attributed to A Verity.

9 recordsLinked to original sources
PubMed1998

Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model.

The role of monocyte chemoattractant protein-1 (MCP-1) in the recruitment of blood-derived monocytes in a model of zymosan peritoneal inflammation was investigated. After zymosan injection (1 mg) a rapid influx of polymorphonuclear leukocytes (PMN) and monocytes into the peritoneal cavity associated with mouse MCP-1 (JE) gene activation and protein secretion in the exudates occurred. MCP-1 production (maximal at 4 h) preceded the accumulation of monocytes (F4/80-positive cells, maximally recovered between 16 and 24 h). Treatment of mice with a single injection of anti-mouse MCP-1 antibody inhibited 16-h monocyte accumulation by approximately 40%, however, a significant decrease in the number of PMN was also measured. Finally, intraperitoneal injection of murine recombinant MCP-1 (1 microg) produced a selective accumulation of monocytes (F4/80-positive cells) into the peritoneal cavity. In conclusion, we show the novel existence of a strict relationship between MCP-1 production and leukocyte accumulation in this model of acute inflammation.

Acute Disease↗
PubMed1994

Copper deficiency secondary to a copper transport defect: a new copper metabolic disturbance.

We describe a 21-year-old man who developed copper deficiency manifested as a demyelinating neuropathy, chronic intestinal pseudo-obstruction, osteoporosis, testicular failure, retinal degeneration, and cardiomyopathy with a tortuous aorta. His serum copper was low and did not increase despite administration of large doses of intravenous copper sulfate. The ceruloplasmin level as measured by an antibody technique was normal, yet ceruloplasmin (Cp) oxidase activity was very low. The Cp amino acid sequence was normal. This suggests that the copper deficiency was caused by a defect in hepatic processing of copper for incorporation into Cp.

Adult↗
PubMed1983

The nerve-muscle pedicle. A visual, electromyographic, and histochemical study.

The nerve-muscle pedicle was studied in dogs using visual, electromyographic, and histochemical means. All methods failed to show evidence of reinnervation. It would appear that the nerve-muscle pedicle operative procedure causes fibrosis and lateral displacement of the vocal cord with a subsequent improvement in the airway. It thus functions as a minimal arytenoidopexy.

Animals↗
PubMed1983

The rabbit isolated arterially perfused intestinal segment preparation: a model for vascular dopamine receptors.

A simple and inexpensive method for the evaluation in vitro of the effects of compounds on postjunctional vascular dopamine (DA) receptors is described. The rabbit isolated perfused K+-contracted mesenteric and ileal vasculature dilates in response to DA, DA receptor agonists, and papaverine. Responses to DA receptor agonists, but not those to papaverine, can be selectively antagonised by cis-(Z)-flupenthixol (pA2 8.5), yet remain unaffected by sulpiride. Comparisons with other models of vascular DA receptors have been made.

Animals↗
PubMedDate not supplied

Immunoperoxidase staining of the choroid plexus in systemic lupus erythematosus.

Immune deposits in the choroid of patients with systemic lupus erythematosus (SLE) are thought to relate to the pathogenesis of central nervous system (CNS) SLE. Using an immunoperoxidase technique, we found the presence of immunoglobulin heavy and light chains in the choroid stroma and/or in the ependymal cells in all of 7 patients with SLE, 2 of 4 with rheumatoid arthritis, but not in 3 subjects without autoimmune disease. The occurrence, pattern or intensity of the immunoglobulin deposits did not distinguish the patients with or without clinical neuropsychiatric manifestations. Thus, the presence of immune deposits in the choroid plexus is not specific for CNS involvement in SLE.

Antibodies, Antinuclear↗