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Biomedical subjects

A Vlad

Publications and source records attributed to A Vlad.

36 records · Page 2Linked to original sources
PubMedDate not supplied

Minimal steric difference study of structural requirements for the luteinizing hormone-releasing hormone (LH-RH) receptor.

Quantitative structure-activity relation for amino acid substitution analogues of the LH-RH decapeptide were established by means of the receptor site mapping procedure based upon minimal steric differences. For a series of 17 analogues of LH-RH, obtained by substitutions of the C-terminal Gly-NH2 residue, a corelation coefficient r = 0.93 was obtained, for a series of 7 analogues, obtained by substitutions of the Leu7 residue, r = 0.95 was obtained. The shape of the LH-RH receptor regions interacting with the C-terminal of the decapetide and with the Leu7-side chain is inferred from this study.

Binding Sites↗
PubMedDate not supplied

Endemic goiter morbidity in Timis county after 30 years of iodine prophylaxis. A dynamic study.

The dynamics of endemic goiter morbidity in Timiş county is evaluated comparing the studies carried out 30 years ago with the present-day ones. A positive correlation is found between the extension and severity of the endemic, on the one hand, and the iodine content of the drinking water sources, on the other. Eradication of the endemic has been achieved by borin gartesian wells (having a higher iodine content than dug wells), by intensive iodine prophylaxis and therapy as well as by the socioeconomic changes characterized by a high degree of pre-urbanization of the country-side.

Adolescent↗