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Biomedical subjects

A W Burrows

Publications and source records attributed to A W Burrows.

12 recordsLinked to original sources
PubMed1983

Changes in plasma sodium concentration in women at the menopause.

A significant increase in the mean plasma sodium concentration and in the fasting urinary Na/Cr ratio was observed in healthy women at the menopause. Both of these changes were reversed by administering oestrogens. None of the above effects appeared to be due to alterations in sodium intake or in renal glomerular function. The most likely cause of the increase in plasma sodium concentration at the menopause appeared to be a decrease in plasma volume since there were also significant increases in the mean plasma albumin and total protein concentrations.

Adult↗
PubMed1981

Reversible hypothyroidism after steroid replacement for Addison's disease.

An insulin-requiring diabetic patient who developed Addison's disease is described. At diagnosis, investigations revealed biochemical hypothyroidism and these abnormalities resolved after replacement therapy for the adrenal failure only. The possible mechanism of this change is discussed in relation to the presence of organ-specific antibodies.

Addison Disease↗
PubMed1981

Beta-thromboglobulin in diabetes: relationships with blood glucose and fibrinopeptide A.

Plasma thromboglobulin concentrations are raised in diabetes. Although patients with angiopathic complications tend to have the highest thromboglobulin, this distinction is not clearly defined. Diabetic subjects with high thromboglobulin also have increased plasma concentrations of fibrinogen and fibrinopeptide A. Abnormal platelet function, therefore, accompanies changes in the coagulation system and suggests a "prethrombotic" state. Increases in plasma glucose induced by an oral glucose load in diabetics are associated with a decrease in plasma thromboglobulin. The role of these changes in the pathogenesis of microangiopathic complications remains speculative.

Adolescent↗
PubMed1978

Plama-thromboglobulin concentrations in diabetes mellitus.

Abnormally high plasma-concentrations of the platelet protein thromboglobulin were demonstrated in a group of 72 diabetic patients. The highest concentrations were found in patients with clinical evidence of tissue damage. Many diabetic patients, without such complications have elevated thromboglobulin levels, and this blood abnormality may predate recognisable clinical lesions.

Adenosine Diphosphate↗
PubMed1978

Diabetic dimorphism according to acetylator status.

Two groups of diabetics and 19 normal controls had their rate of acetylation of sulphadimidine measured. Among 47 patients with maturity onset diabetes the 29 fast acetylators were older at diagnosis and, at a given glucose concentration, had a higher pretreatment fasting insulin concentration than slow acetylators. They also had a larger first-phase insulin secretion in response to intravenous glucose both before and after one month's dietary treatment. The greatest difference between fast and slow acetylators was in the first-phase secretion of insulin after a month's treatment. The proportion of fast acetylators among the second group of diabetics, who had been admitted to improve their glucose concentrations or for treatment of tissue damage, was similar to that among the normal controls (50% and 47% respectively). The data seem to indicate that diabetics are fast acetylators unexpectedly often, but it is not clear whether the dimorphism according to acetylator status produces a differential risk of neuropathy or of any other type of diabetic tissue damage.

Acetylation↗
PubMed1975

Thyroid hormones in the elderly sick: "T4 euthyroidism".

Thyroid function and serum levels of triiodothyronine (T3) and thyroxine (T4) were investigated in 79 euthyroid geriatric patients. Of the 59 inpatients and 20 outpatients 35 (59%) and 2, respectively, had low T3 levels. In contrast, 7 (12%) and 6 (30%), respectively, had raised T4 levels. Two further patients were excluded from the study because of raised levels of thyroid-stimulating hormone. Thyroxine-binding globulin was greatly increased in both groups of patients, but low serum albumin levels were present in 31 (39%). Despite these changes free T3 and T4 indices closely followed total T3 and T4 levels. The difference between the two groups of patients did not correlate with body weight, diagnostic categories, age, drug treatment, or duration of stay in hospital.

Aged↗