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Biomedical subjects

A W Dade

Publications and source records attributed to A W Dade.

16 recordsLinked to original sources
PubMed1983

Caprine beta-mannosidosis: clinical and pathological features.

Beta-mannosidosis, an inherited defect of glycoprotein catabolism associated with deficiency of tissue beta-mannosidase and accumulation of Man(beta 1-4)GlcNAc and Man(beta 1-4)GlcNAc(beta 1-4)GlcNAc, appeared in four of 13 offspring of a single pair of clinically normal, related Nubian goats. Neurological examinations revealed that all four affected goats were unable to rise or walk. All had facial dysmorphism, dome-shaped skulls, small palpebral fissures, carpal contractures, hyperextension of the pastern joints, proximal muscle atrophy, intermittent ocular oscillations resembling pendular nystagmus, marked intention tremor, and deafness. With intensive care, three affected kids were hand-reared and then killed at 1, 7, and 21 days of age. Macroscopically, there were paucity of myelin in the cerebral and cerebellar hemispheres and ventricular dilatation. Microscopically, the extent and distribution of cytoplasmic vacuolation, myelin paucity, axonal spheroids, and filamentous expansions were evaluated in the cerebrum, cerebellum, brainstem, spinal cord, and peripheral nerves of the four affected kids and two age-matched, clinically normal kids. Widespread cytoplasmic vacuolation correlated with the previously reported accumulation of oligosaccharides in the brain and kidney and the deficiency of tissue beta-mannosidase. beta-Mannosidosis, not yet identified in man or other species, is characterized by distinctive neonatal clinical, pathological and biochemical features which differentiate it from the alpha-mannosidosis and other inherited diseases of glycoprotein catabolism.

Animals↗
PubMed1977

Cerebral nematodiasis in captive nutria.

Of 35 nutria (Myocaster coypus) at a city zoo, 20 died or were killed because of a progressive central nervous system disease. On the basis of histopathologic findings, a diagnosis of cerebral nematodiasis complicated by nosematosis was made. The only significant management change prior to illness was the feeding of poplar tree branches from a lowland area inhabited by skunks and raccoons. Neurologic disturbances gradually ceased within 2 months after control measures were initiated and the practice of provided poplar branches as a source of roughage was discontinued.

Animals↗
PubMed1976

Megakaryocytic myelosis in a cat.

A myeloproliferative disorder in a cat was characterized by abnormal proliferation of megakaryocytes in the bone marrow and by severe, nonregenerative anemia. The number of circulating thrombocytes was increased markedly, with many giant and morphologically bizarre forms. Terminally, the circulating blood contained large numbers of undifferentiated blast cells. The spleen and liver were infiltrated by megakaryocytes and mononuclear mesenchymal cells of uncertain identity.

Animals↗
PubMed1975

An epizootic of cerebral nematodiasis in rabbits due to Ascaris columnarus.

An epizootic of cerebral nematodiasis due to ascaris columnaris occurred in a commercial rabbitry, and 80 diseased rabbits died or were killed. The morbidity was high in groups of recently purchased rabbits and in the offspring of 12 breeder rabbits. The breeder rabbits which had been on the farm for more than a yr survived the outbreaks. Wild animals and birds had access to the facilities, but raccoons and skunks were never observed. A columnaris larvae were found on histopathologic examination. and live larvae were recovered from brains of 2 diseased rabbits.

Animals↗