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Biomedical subjects

A W Eade

Publications and source records attributed to A W Eade.

6 recordsLinked to original sources
PubMed1981

Pyrophosphate arthropathy in hypophosphatasia.

The association of hypophosphatasia and pyrophosphate arthropathy in an adult patient has been described on 1 previous occasion. We report a further 2 patients with this disease combination. One patient suffers from the type of hypophosphatasia that presents in adult life, with fractures that are either spontaneous or the result of minimal trauma. The other patient suffered from the severe type of hypophosphatasia that presents in infancy but survived longer than is usual; the necropsy findings on this patient are reported.

Arthritis↗
PubMed1979

A health centre survey of rheumatism.

In order to assess the size and nature of the workload in general practice resulting from rheumatic diseases and to assess the value of the National Insurance 'Sick Note' as an index of this, a prospective survey was carried out. The survey was based upon a health centre which provides the primary medical care for the majority of the inhabitants of a small town. During four periods of two weeks at a different season of the year, all patients considered by the family doctor to be suffering from a rheumatic condition were seen by a visiting rheumatologist. Firm diagnostic criteria were applied and functional capacity was assessed and related to both the diagnosis and symptoms. The rheumatic diseases and conditions accounted for about 5% of total attendances and a slightly greater proportion of total surgery time. This is less than suggested by some previous studies of different design. The sick notes provided such a poor index of the size and nature of the problem that information based merely upon retrospective analysis of these is probably of little practical value.

Adult↗
PubMed1978

Pyogenic arthritis and rheumatoid disease: the importance of the infected foot.

During a nine-year period (1968--76) 75 patients were admitted to Coventry Hospitals becaues of pyogenic arthritis. Of these patients, 22 suffered from pre-existing rheumatoid disease, and in these the foot was the most common site of primary infection. Adequate and energetic management of foot problems and associated skin sepsis in patients suffering from rheumatoid disease appears to offer the best opportunity of reducing the incidence of superimposed pyogenic arthritis.

Adolescent↗
PubMed1975

A double-blind comparison of naproxen with indomethacin in osteoarthrosis.

Twenty-two patients with osteoarthrosis of one or both knee joints and 28 patients with osteoarthrosis of one or both hips completed a double-blind trial of 500 mg naproxen daily versus 100 mg indomethacin daily. All patients had been on other active medication up to the start of the trial. Identical trial designs were followed with both classes of patients, namely, a crossover pattern of four weeks on each drug with patients being assessed at -2, 0, 2, 4, 6, and 8 weeks. Assessments made included objective measurement of joint range, stair climbing and walking times, and subjective grading of pain present during normal activity, of which the patient kept a daily record. Patients were also questioned at each clinic visit regarding possible side effects. Study groups were comparable for both drugs. In the majority of subjective and objective parameters, there were significant improvements from baseline on both drugs of statistically comparable magnitude. Significantly fewer side effects were noted during the period on naproxen compared with those on indomethacin. There were no abnormalities discovered in hematologic or biochemical tests performed during the course of the trial.

Anti-Inflammatory Agents↗