Biomedical subjects

A W Eckert

Publications and source records attributed to A W Eckert.

11 recordsLinked to original sources

PubMed2006

Bisphosphonate-related jaw necrosis--severe complication in maxillofacial surgery.

Bisphosphonates are used as potent inhibitors in metastatic bone lesions. They can reduce skeletal burden and prevent bony metastases. They are integral in the treatment of some tumours like breast cancer, prostate cancer and multiple myeloma. As a side effect, these drugs also may cause severe jaw necrosis. Twenty-four patients with bisphosphonate-related jaw necrosis were analyzed in a clinical study. These necroses mostly appeared after administration of aminobisphosphonates. Recurrent avascular necroses were found after changing from Pramidronate to Zoledronate. All patients were treated by resection of necrotic bone. Repeated surgical interventions were required with about 25% of the patients. The management of patients with bisphosphonate-related jaw necrosis remains extremely difficult and includes surgical procedures as well as the eradicating of the necrotic bone including antibiotic therapy. The prevention of such complications consists in a minimization of dental surgical interventions and an avoidance of ulcers by dental prosthesis.

Bone Neoplasms↗

PubMed2006

[Bone metastases in the maxilla as first manifestation of renal cell cancer. A case report].

BACKGROUND: Bone metastases in the upper jaw are relatively rare but not unusual in oral and maxillofacial surgery. In many cases finding the primary tumour is difficult because of its occult location. CASE REPORT: We describe a 53-year-old female patient who suffered from a tumor in the oral cavity. The first histological and clinical diagnosis revealed a granuloma pyogenicum. Because of the delayed healing process another biopsy became necessary showing a metastasis of an unknown primary tumor. Diagnostic procedures detected an adenocarcinoma of the left kidney with pelvic metastases. Appropriate surgical intervention and chemotherapy were subsequently initiated. CONCLUSION: The present case report demonstrates how difficult it can be to provide the right pathological diagnosis in biopsy material even regarding obvious malignancy. Therefore thorough diagnostic efforts are indispensable to facilitate the causal treatment of an unknown primary tumor.

Biopsy, Fine-Needle↗

PubMed2005

Measurement of oxygen partial pressure in the mandibular bone using a polarographic fine needle probe.

In this study, the oxygen partial pressure in the cancellous bone substance of the mandible was measured for the first time with a polarographic fine needle probe. This has so far only been established in soft tissue. The aim was to prove and to test the feasibility in principle of this method of measurement in order to ascertain the normal values for the O2 partial pressure in healthy bone. These values were afterwards compared with the results of measurements in areas of different pathological bone conditions in order to assess the clinical suitability of the method for "mapping" during mandibular resection. Measurements of oxygen partial pressure were made in a total of 42 patients (16 women, 26 men). Of these, 12 patients with clinically normal bones served as a control group. Seventeen patients had osteoradionecrosis following radiation treatment, and 13 patients presented with chronic osteomyelitis of the mandible. All measurements were carried out with a polarographic fine needle probe applied to the cancellous bone substance. The statistical analysis included a comparison of the mean values of the oxygen partial pressures measured. No statistical correlation between oxygen partial pressure and pH and hemoglobin values could be detected. The average oxygen partial pressure in the healthy mandibular bone was 71.4 mmHg. In non-healthy bone, the value fell to an average of 30.6 mmHg (osteoradionecrosis 32.3 mmHg, chronic osteomyelitis of the mandibular bone 28.4 mmHg). Statistically, the differences in the group values ascertained were highly significant (P < 0.005). The data found show that this method can be successfully used to detect poorly perfused bone. The values are reproducible and reflect the clinical situation. In the long term, the method appears to be a suitable diagnostic tool for assessing the oxygen supply in bone in studying various clinical problems related to bone surgery.

Adult↗

PubMed2005

[Soft tissue infections in oral, maxillofacial, and plastic surgery. Bacterial spectra and antibiotics].

BACKGROUND: Soft tissue infections in the maxillofacial region are mainly caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli but also by members of the genera Enterococcus, Klebsiella, and Enterobacter, respectively. METHODS: In a prospective study 96 patients with severe maxillofacial non-odontogenic postoperative soft tissue infections were analyzed with regard to the bacterial spectrum and resistance patterns against antibiotics. The dominating bacteria were Streptococci (25% of the isolates) and Staphylococci (24% of the isolates). In addition, members of Enterobacteriaceae were isolated in approximately 10% of the cases. The most frequent anaerobes found were as follows: Peptostreptococcus, Eubacterium, Prevotella and Fusobacterium. RESULTS: The resistance rates against antibiotics found were: penicillin G 36%, ampicillin 42%, and doxycycline 36%. In addition, the resistance rate against erythromycin and clindamycin was 26% and 7%, respectively. No resistant strains were detected against vancomycin and teicoplanin. All anaerobes showed a low antimicrobial resistance as previously described for odontogenic infections. CONCLUSION: In summary, soft tissue infections in the maxillofacial region present a different spectrum of bacteria in contrast to the well-investigated odontogenic infections. Antibiotic administration should be, whenever possible, performed after differentiation of involved strains and resistogram. The most promising antibiotics are imipenem, meropenem, and ciprofloxacin as well as cefotiam. Modern fluoroquinolones will be the antibiotics of the future.

Adolescent↗

PubMed2005

[Bacterial spectra and antibiotics in odontogenic infections. Renaissance of the penicillins?].

BACKGROUND: The role played by odontogenic infection in dental, oral, and maxillofacial surgery is not to be underestimated even at the present time. An extensive, standardized, prospective study was performed with the intention of verifying the bacterial spectrum of odontogenic infections to evaluate antibiotic sensitivity. MATERIAL AND METHODS: Bacterial spectra and resistograms of 65 patients with an odontogenic infection were analyzed in a prospective study under standardized conditions for specimen collection and transport. RESULTS: A total of 226 bacterial strains were analyzed. The ratio between anaerobes and aerobes was approximately 2:1. The most frequent aerobes were members of the genera Streptococcus (46 isolates), Staphylococcus (10 isolates), and Neisseria (9 isolates), respectively. The anaerobic gram-positive spectrum was dominated by members of the genera Eubacterium (19 isolates), Peptostreptococcus (16 isolates), and Actinomyces (12 isolates). The most frequently isolated gram-negative anaerobes were Prevotella (46 isolates), and Fusobacterium (21 isolates). The overall resistance to antibiotics was very low: only 7.3% of all bacteria were resistant to penicillin G/V, and 8.8% showed resistance to ampicillin. The resistance rates to other beta-lactam antibiotics were 4.4% to piperacillin and 0.6% to imipenem, respectively. Penicillin G presented the highest antimicrobial activity among aerobes: only 4.5% of anaerobic strains were resistant of penicillin G. The other resistance rates of anaerobic bacteria to antibiotics were as follows: ampicillin 24%, doxycycline 34%, erythromycin 18%, and clindamycin 9.3%. Penicillin G was also highly antimicrobially active to anaerobes. The resistance rates were: penicillin G 8.1%, ampicillin 2.6%, doxycycline 9.2%, erythromycin 10.2%, and clindamycin 1.4%, respectively.

Adolescent↗

PubMed2003

[Temporomandibular function after malocclusion operations compared with a representative population group study].

AIM: The temporomandibular function of patients after orthognathic surgery was evaluated with the Helkimo index (D 0-III) and compared with a normal population. PATIENTS AND METHODS: Temporomandibular disorders (TMD) were evaluated with the Helkimo index (D 0-III) in a group of patients (n=105, F=69, M=36) after osteotomies. The average follow-up time was 47 months (9-141 months). The osteotomies performed were as follows: 58 bilateral sagittal split osteotomies, 12 Le Fort I osteotomies, 22 bimaxillary osteotomies, and 13 segment-osteotomies. A control group (n=202, F=114, M=88, age 20-39 years) was examined in an epidemiological study. The statistical analysis was performed using Windows software SPSS 10.0. RESULT: In 82.8% of the patients no symptoms or mild dysfunction were found. The comparison between the patient group (31.4%) and the control group (31.7%) revealed a similar frequency. The most frequent dysfunction was a reduced mobility of the mandible, which determined the statistical significance (p<0,05) between the patients and the control group for the dysfunction group D II and D III. The chi-square test could not detect any difference between sex and the kind of osteotomy with regard to dysfunction.

Adult↗

PubMed2002

[Patient satisfaction with the outcome of surgical orthodontic intervention and effect of esthetic and functional criteria].

BACKGROUND: The aim of the study was to analyze the influence of possible temporary or permanent disorders of sensation on the degree of the patient's satisfaction following an orthognathic operation. PATIENTS AND METHODS: After an average of 47 months (range: 9-141), a follow-up examination was performed in 78 women (64.5%) and 43 men (35.5%) with an average age of 24.3 years (range: 19-40) at the time of operation. In 67 cases there had been a sagittal division of the mandible, in 11 cases a Le Fort I osteotomy, in 26 cases a bimaxillary osteotomy, in 4 cases an isolated genioplasty, and in 13 cases a segmental osteotomy in the upper or the lower jaw. In the peripheral area supplied by the nerves V2 and V3 sensation was examined by the two-point discrimination test and the result related to the patients' satisfaction using the chi-square test. RESULTS AND DISCUSSION: The following qualities of sensation were recorded: anesthetic (2.7%), hypesthetic (16.6%), paresthetic (8.3%), and normesthetic (72.4%). The patients' satisfaction was rated as very satisfied in 51.3%, as satisfactory in 44.8%, and in 3.9% the patients' expectations had not been fulfilled; 75% regarded their outward appearance as markedly improved and a good 50% of the patients noted improved mastication. Therefore, three-fourths of all the patients would even be willing to be operated on again. Two-dimensional analysis, however, demonstrated only a weakly significant positive relationship between patient satisfaction and the preserved, or restored, sensation in the trigeminal region.

Adult↗

PubMed2002

[The FAMI screw for temporary intermaxillary fixation. Report of experiences for extending indications].

The aim of this study was to demonstrate the suitability of the FAMI screw (fixation and adaptation in mandibular injuries) for maxillomandibular fixation in the maxillofacial area in orthognathic and trauma surgery. This FAMI screw was used in 28 patients for maxillomandibular fixation with wiring or elastics. The screw is inserted into the labial or buccal surfaces of the alveolar process without predrilling. Adequate intermaxillary fixation with balanced occlusion was created intraoperatively in all patients. In comparison with conventional splinting methods, this technique was far less time-consuming. The use of the FAMI screw has the advantage of being quick and simple, particularly if only a brief period of maxillomandibular immobilization is planned. Furthermore, the risk to the surgeon of sustaining a puncture injury from wire ligatures is distinctly reduced. Screws can be removed without local anesthesia. The above-mentioned method is minimally traumatic, effective, timesaving, and hence inexpensive. It can be used for maxillomandibular immobilization in dentate as well as in edentulous patients.

Bone Screws↗

PubMed2001

[Complications in surgical treatment of malocclusions. Report of 50 years experience].

BACKGROUND: During the past few decades, orthognathic surgery has become routine in oral and maxillofacial surgery. As these surgical interventions are elective, the goal is a low complication rate. The aim of this study was to analyze the intraoperative and postoperative complications after orthognathic surgery without considering orthodontic relapse. PATIENTS AND METHODS: The medical files of 507 patients were reviewed who had been treated in the department of oral maxillofacial surgery at the Martin-Luther-Universität in Halle-Wittenberg during a period of 51 years. The indication for orthognathic surgery was mandibular hyperplasia in 314 cases (61.9%), mandibular hypoplasia in 69 cases (13.6%), mandibular hyperplasia with a frontal open bite in 53 cases (10.5%), maxillary hyperplasia with a cleft in 30 cases (5.9%), maxillary hyperplasia in 22 cases (4.3%), severe laterognathia in 10 cases (2.1%), and isolated frontal open bite in 9 cases (1.5%). The surgical procedures were as follows: bilateral sagittal split osteotomy (n = 336, 66%), Le Fort I osteotomy (n = 29, 5.9%), bimaxillary osteotomy (n = 35, 6.3%), and segment osteotomy (n = 107, 21.1%). Rigid fixation was used in 147 patients. RESULTS: In 55% of the patients a postoperative neurosensory deficit of the inferior alveolar nerve was observed, which was only found in 28% after 1 year. Inflammatory wound healing was found in 5.3% of the patients. CONCLUSION: Due to antibiotic perioperative prophylaxis and modern rigid osteosynthesis devices, orthognathic surgery has become a routine method in maxillofacial surgery with predictable surgical results.

Cross-Sectional Studies↗

PubMed2000

[Pathogen spectrum and resistance status of exclusively anaerobic odontogenic infections].

Out of 440 dentogenic pyogenic infections, 171 exclusively caused by anaerobes were investigated to understand the importance of anaerobic bacteria in dental pyogenic processes better. Grampositive anaerobic bacteria dominated. The predominant grampositive isolates in monoinfections were Peptostreptococci and in the case of mixed infections, strains of the genus Eubacterium. Strains of Prevotella and Porphyromonas dominated the gramnegative anaerobic spectra. The resistance to penicillin was very low. Altogether, only one strain of Prevotella oris and one strain of Prevotella oralis showed resistance to penicillin.

Bacteria, Anaerobic↗

PubMed2000

Surface-modification of polystyrene-microtitre plates via grafting of glycidylmethacrylate and coating of poly-glycidylmethacrylate.

Photografting of glycidylmethacrylate (GMA) onto commercially available polystyrene-microtitre plates was carried out in methanol as well as butanol with benzophenone (BP) as photoinitiator. Alternatively, prepolymers of polyglycidylmethacrylate (PGMA) were synthesized in methanol with azo-iso-butyrodinitrile (AIBN) as initiator and dip-coated onto polystyrene-microtitre plates. Both modification methods were tested in order to reach a high binding capacity for proteins. Peroxidase was used as model protein. In addition, the immobilization of myelin basic protein (MBP) to epoxy-modified microtitre plates is shown and a MBP-based ELISA has been developed.

Biocompatible Materials↗