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Biomedical subjects

A W Edwards

Publications and source records attributed to A W Edwards.

14 recordsLinked to original sources
PubMed1992

Metrical Venn diagrams.

A type of Venn diagram is described which enables the observed frequencies in a 2x2x2 contingency table to be compared with their expectations on the hypothesis of no associations.

Gene Frequency↗
PubMed1992

The structure of the Polar Eskimo genealogy.

The structure of the genealogy of the Polar Eskimos from the Thule District of North Greenland is studied by a variety of computational and graphical means, some of them novel. It is shown that although the level of inbreeding in the population is low, the genealogy is intricately connected, as if conforming to the requirement that spouses are as unrelated as is possible in a small population.

Greenland↗
PubMed1989

Probability and likelihood in genetic counselling.

The aim of this paper is to clarify some of the concepts used in the calculation of risk in genetic counselling. The use of probability as a measure of risk in a particular case is reviewed, with special reference to the Fisher-Neyman controversy. The technical concept of likelihood is then introduced and applied to risk probabilities themselves. The difficulties of interpretation are discussed, with a distinction drawn between calculating the risk for a child and inferring the genotype of his mother, even though the risk is wholly determined by the genotype. Fiducial inference is briefly mentioned, and the paper ends with a discussion of the problem which arises when the functional relationship between an unknown parameter and the unknown risk is not 1:1. The conclusion is tentatively reached that risk can only be gauged by probability and thus that prior probabilities must sometimes be assumed, but the paper is primarily intended as a guide and catalyst for the informed discussion of some of the difficulties, which may involve ethical dilemmas.

Genetic Counseling↗
PubMed1977

Selection at a multiallelic locus: Feller's transformation.

An explanation of Feller's result enabling the contours of mean viability at a triallelic locus to be rendered circular is offered, and a proof given which does not involve the direct use of homogeneous coordinates. In a subsequent paper we propose to use the fact that the same transformation also maps the contours of equal average effect for each gene into circles to establish further results.

Alleles↗