The power of consolidation: a case study.
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Chemistry, Clinical↗
Biomedical subjects
A W Jekelis
Publications and source records attributed to A W Jekelis.
Beta-blocker effects on sexual function in normal males.
Among the antihypertensives currently in use, the sympatholytic drugs (e.g., central alpha-agonists, beta-blockers) and diuretics are most commonly associated with sexual side effects. Previous reports of sexual dysfunction associated with these drugs have been based entirely on retrospective and self-report data. This is the first study to date to investigate beta-blocker effects on sexual function by means of physiological (NPT), subjective, and hormonal measures. Four beta-blockers with different ancillary properties (atenolol, metoprolol, pindolol, propranolol) were evaluated in a placebo-controlled, double-blind, Latin-square design. Thirty healthy male volunteers received, in counterbalanced order, each of the four drugs and 1 week of placebo testing. Significant drug effects on both total and free testosterone were found during treatment with all four beta-blockers, although it appeared that the nonselective drugs (pindolol, propranolol) were associated with the greatest reduction in testosterone. No significant effects were found on measures of cortisol or cholesterol. Analysis of NPT and self-report data yielded inconclusive results, perhaps due to the confounding effects of sleep disruption and the brief duration of treatment in this study. Inspection of individual records, however, suggested that some subjects may be especially vulnerable to sexual dysfunction in association with propranolol.
Adrenergic beta-Antagonists↗
Differential response of plasma glucose, amino acids and nonesterified fatty acids to insulin in depressed patients.
Levels of plasma glucose, nonesterified fatty acids and total amino acids at various times after insulin administration were determined in patients with either major depressive disorder or dysthymic disorder and in normal control subjects. For the first 30 min following insulin administration, the rate of change in glucose levels was significantly less among the patients with major depressive disorder than among either the patients with dysthymic disorder or the normal control subjects. However, during the same time period, the rates of decline in nonesterified fatty acids and total amino acids were indistinguishable among the three subject groups. Therefore, the insulin resistance in terms of glucose levels that is observed in patients with major depressive disorder is not generalized to other substances affected by insulin.
Adult↗