PubMed Health⌕ Search

Biomedical subjects

A W Kay

Publications and source records attributed to A W Kay.

At least 19 recordsLinked to original sources
PubMed1983

Time of onset of carcinoma of the stomach following surgical treatment of duodenal ulcer.

In a review of 1,092 patients with histologically proved carcinoma of the stomach, it was found that 40 patients (3.8 per cent) had previously undergone surgical treatment of a duodenal ulcer. In 13 patients, truncal vagotomy had been carried out, while 27 patients had a partial gastrectomy. Patients having truncal vagotomy and who subsequently had carcinoma of the stomach develop did so at a significantly earlier age than those having partial gastrectomy (55 years compared with 64 years). Carcinoma of the stomach was diagnosed after an average interval of 8.5 years in the vagotomy group compared with 24.0 years in the nonvagotomy group. Possible explanations for this observation are considered. Patients in the vagotomy group were less likely to have a resectable tumor.

Adenocarcinoma↗
PubMed1975

Results of adrenal surgery in patients with hypertension, aldosterone excess, and low plasma renin concentration.

Fifty patients with hypertension, aldosterone excess, and low plasma renin concentration underwent adrenal surgery. There was a highly significant fall in mean systolic and diastolic pressures after the operation. The mean postoperative diastolic pressure fell to strictly normal levels, however, in only 19 out of 38 patients from whom an adrenocortical adenoma was removed and in only two out of 10 non-tumour patients. There was a significant correlation between the fall in blood pressure during spironolactone treatment and after adrenal surgery though levels were generally slightly lower during the former therapy. It is suggested that removal of an aldosterone-producing adenoma is the treatment of choice provided a good preoperative hypotensive response to spironolactone occurs, while the treatment of choice for non-tumour patients is often long-term spironolactone.

Adenoma↗
PubMed1973

Ch.M. Glasgow.

Explore the source record for details and available documents.

Education, Medical, Graduate↗
PubMed1973

Truncal vagotomy and drainage for chronic duodenal ulcer disease: a controlled trial.

The results of elective truncal vagotomy and drainage in 547 duodenal ulcer patients are reported. Altogether, 204 patients were randomly allocated to pyloroplasty and 200 to gastrojejunostomy. In 101 patients gastrojejunostomy was electively chosen and in 42 patients the duodenum was opened to confirm the diagnosis. Operative mortality was 0.5%, the incidence of proved recurrent ulceration 3.3%, severe dumping 2%, and severe diarrhoea 1.1%. There were no significant differences between the groups, with the exception of bilious vomiting which occurred more often in patients with gastrojejunostomy.

Adult↗
PubMed1973

Exocrine secretory responses of the pancreas to insulin and to a meat meal in dogs.

Studies in five dogs with chronic pancreatic and gastric fistulae have shown that insulin-induced vagal stimulation of the pancreas (gastric fistula open) resulted in protein and bicarbonate outputs very much smaller than those obtained with a 400-g meat meal. However, when the insulin-activated gastric acid secretion was allowed access to the duodenum (gastric fistula closed) peak outputs of both bicarbonate and protein were observed which were closely similar to the response to the meal. These findings suggest that insulin-induced hypoglycaemia results in stimulation of the pancreas within the physiological range when gastric acid is allowed access to the duodenum with consequent release of secretin.

Animals↗