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Biomedical subjects

A W Kilroy

Publications and source records attributed to A W Kilroy.

At least 19 recordsLinked to original sources

Injury of the sciatic nerve associated with acetabular fracture.

In order to document functional outcome, we followed fourteen patients who had an injury of the sciatic nerve associated with a displaced acetabular fracture for a mean of twenty-seven months. In three of the patients, the injury was iatrogenic. Electromyography was useful in the localization and determination of the severity of the injury. According to the functional scale that was used, all but one patient had a satisfactory (fair or better) functional outcome, but eleven patients had residual neurological sequelae that ranged from minor paresthesia to footdrop. Seven patients who had an injury of both the tibial and peroneal divisions of the sciatic nerve had complete or nearly complete motor and sensory recovery of the tibial component. The patients who had isolated, mild involvement of the peroneal nerve had a favorable prognosis, but those who had a severe injury of the peroneal component, whether it was isolated or associated with an injury of the tibial component, did not recover good function.

Acetabulum↗

Macrocephaly with head growth parallel to normal growth pattern: neurological, developmental, and computerized tomography findings in full-term infants.

Fifteen infants with macrocephaly had a head growth pattern parallel to 2 SDs above normal. In eight patients with initial and subsequent normal findings on neurological and developmental examinations, computerized tomography (CT) showed slight ventricular dilation and increased width of the subarachnoid space anteriorly. The other seven patients had abnormal results from neurological or developmental examinations. The CT findings in two were similar to those in the first group; in four, other abnormalities were observed; and one had a normal scan. None of the 15 infants required shunting. In infants with this head growth pattern, a similar CT scan with ventricular dilation and widened subarachnoid space could be found in patients with normal or abnormal results from neurological and developmental examinations. Those infants with this CT scan pattern and normal neurological and developmental findings appear to have a benign condition.

Cephalometry↗

Cramps, muscle pain, and tubular aggregates.

A 31-year-old man had a nine-year history of exercise-induced cramps and muscle pain without myoglobinuria. Results of laboratory investigations differentiated his condition from the known disorders of carbohydrate and lipid metabolism. Light and electron microscopic examination of a muscle biopsy specimen showed tubular aggregates confined to type II fibers. Although the relationship of tubular aggregates to muscle cramps is uncertain, this association has been described previously and may be significant.

Adult↗

Acetazolamide in the treatment of pyruvate dysmetabolism syndromes.

Two children with periodic weakness beginning in infancy were demonstrated to have abnormalities in pyruvate metabolism by the production of lactic acidosis following a glucose load. Daily oral doses of acetazolamide reduced the frequency of attacks and reversed the abnormal response to glucose loading. The mechanism of action of acetazolamide in these patients is not clear.

Acetazolamide↗

Botulism in infancy. Report of a case.

A 22-day-old infant developed infant botulism characterized by profound weakness, hypotonia, respiratory arrest, areflexia, ptosis, pupils that responded poorly to light, and absent gag reflex. Stool examination yielded Clostridium botulinum type B organisms and type B toxin. Electromyography provided rapid diagnostic assistance. With supportive care, reovery was complete. This "new" disease probably is more common than now appreciated.

Botulism↗

Trigonocephaly and the 11q- syndrome.

A seventh case of deletion of the distal long arm of a chromosome 11 is described. As in other cases with this karyotypic abnormality, trigonocephaly is the most noticeable phenotypic peculiarity. A review of common developmental and dysmorphic features among the seven recognized cases is presented.

Chromosome Aberrations↗

Tiglicaciduria in propionicacidaemia.

Tiglic acid, which has not previously been found in human body fluids, was recently detected in the urine of two patients with propionicacidaemia. These patients had a documented defect in the oxidation of propionate. A competition between acrylyl-CoA and tiglyl-CoA for crotonase could explain the accumulation of tiglic acid.

Acrylates↗