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Biomedical subjects

A W Klein

Publications and source records attributed to A W Klein.

At least 19 recordsLinked to original sources
PubMed1995

Collagen and me.

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Collagen↗
PubMed1985

Substances for soft tissue augmentation: collagen and silicone.

Zyderm injectable collagen and silicone are both used for soft tissue augmentation. Neither is perfect. Critical factors associated with their use include lesion selection and injection technique. Both may have immediate and delayed adverse reactions.

Collagen↗
PubMed1984

Injectable collagen update.

Injectable collagen (Zyderm Collagen Implant) has proved to be an effective means of treating certain soft tissue contour defects. A highly concentrated form of the material (65 mg/ml) is now available, and several contraindications to the use of injectable collagen have been removed or changed. This article reviews these changes and provides updated information regarding the safety of this material, the treatment of adverse reactions, and injection techniques that enhance correction.

Autoimmune Diseases↗
PubMed1983

Implantation technics for injectable collagen. Two and one-half years of personal clinical experience.

The successful use of injectable collagen, a xenogeneic material indicated as a tissue replacement for correcting certain soft tissue anomalies, depends primarily on appropriate lesion selection and proper technic. Treatment with injectable collagen yields best results in soft, distensible lesions with relatively smooth margins. Lesions most amenable to correction include acne scars, steroid- or disease-induced areas of atrophy, glabellar furrows, nasolabial lines, postrhinoplasty irregularities, and depressed skin grafts. Optimal correction with the fewest number of injections is chiefly dependent upon deliberate overcorrection and superficial intradermal placement of the material. Outlined here are my experiences with over 1,000 patients treated with injectable collagen for a variety of soft tissue deficiencies.

Acne Vulgaris↗
PubMed1983

Scanning electron microscopy of soy protein-induced damage of small bowel mucosa in infants.

Observations are reported by scanning electron microscopy (SEM) of soy protein-induced villous atrophy and mucosal recovery in two infants aged 5 weeks and 4 1/2 months. Whereas, by light microscopy, the mucosal lesions appeared similar, i.e., a flat mucosa, their appearance by SEM was different: the damage appeared more severe in the younger infant, although there was a shorter period of exposure to soy protein. The mucosal architecture was restudied 6 weeks after the initial biopsy. The degree of mucosal reconstruction was more advanced in the older infant--the one who showed less severe damage by SEM on the first biopsy. Although these investigations by SEM of damaged small bowel mucosa in soy protein intolerance did not contribute definite information to clarify the pathogenesis of villous atrophy in this condition, the injury was consistent with a lectin-induced toxicity, similar to the one postulated for celiac disease. SEM seems eminently suited to study of the effect of interactions between environment and host at mucosal surfaces; and finer gradations of damage to small bowel mucosa can be determined better by SEM, while this is not possible by light microscopy. Of interest was the rather extensive colonization of the mucosal surface by microorganisms in one of the two patients. However, the contribution of microbial colonization to mucosal damage could not be assessed.

Biopsy↗
PubMed1982

The effect of aging on rat liver regeneration.

The effect of age on hepatocyte mensuration and mitotic activity 48 h after partial hepatectomy was investigated in rats. Both age and partial hepatectomy had significant effects upon hepatocyte counts per microscopic field. The number of hepatocytes per microscopic field declined with age in the control groups of different advancing ages and in the experimental groups of advancing ages. There was essentially no mitotic activity in the livers of the control groups. However, mitotic counts were greatly increased in livers from those animals that were partially Hepatectomized; the increase in mitotic activity in the 13-month-old animals was double over that observed in both the very young and the very old.

Aging↗
PubMed1982

The aesthetics of the preauricular graft in facial reconstruction.

In the past six years we have used 55 preauricular full-thickness skin grafts to reconstruct defects of the nose, medial canthal area, forehead, and lip. Results have been good to excellent in all cases. The donor incision is the same one used for a rhytidectomy in which the sole reason for operation is cosmetic. Hence the donor scar in this area must certainly be considered cosmetically acceptable.

Face↗
PubMed1981

Lead accumulations in brain, blood, and liver after low dosing of neonatal rats.

Newborn rat pups were treated in seven groups: Group 1, the control, was untreated and killed at birth (day 1); Groups 2, 3, and 4 were treated on postnatal days 1 through 10 with respectively saline or lead acetate, 5.0 mg/kg and 7.5 mg/kg body weight; Groups 5, 6, and 7 were treated with the same respective dosages on days 11 through 20. Cerebellum, cerebral cortex, brainstem plus hippocampus, liver, and blood were analyzed for lead. Neonatal rats killed at birth all contained some lead, the cerebellum having the highest concentration. Tissue from most treated groups accumulated lead in a dose-dependent manner. A comparison of lead concentrations between the organs of rats dosed days 1-10 and rats dosed days 11-20 indicated that the latter accumulated less lead per gram of tissue (p less than 0.05) than their younger litter mates.

Animals↗
PubMed1975

Cancer of the lip.

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Carcinoma, Squamous Cell↗