Biomedical subjects
Publications and source records attributed to A W McKenzie.
The occurrence of multiple autoimmune conditions in an individual and in families is well known. We wish to report the simultaneous occurrence of bullous pemphigoid and primary biliary cirrhosis in an individual who also suffered from vitiligo. The association adds to the documentation of bullous pemphigoid co-existing with other autoimmune disorders.
Tissue typing was performed on lymphocytes of sixty-two patients with guttate psoriasis, in forty-four of whom this was the first manifestations of the disease. In 84% of cases, the guttate psoriasis was preceded by a clinical infection. A highly significant excess of antigen W17 (HLA-BW17) was found in patients when compared with healthy population. In common with some other studies antigens HL-A13 (HLA-B13), W15 (HLA-BW15) and W21 (HLA-BW21) were found in excess but these became non-significant after correction for the number of antigens studied. 68% of patients who had guttate psoriasis de novo, subsequently developed persistent plaque psoriasis.
Two cases of prurigo nodularis are described. Each is considered to have a gluten sensitive enteropathy. This association may be one facet of prurigo nodularis.
A new formulation of hydrocortisone with vasoconstrictor activity has been shown to be effective clinically and was more effective in a 0.1% concentration than 1.0% Hydrocortisone Cream BPC. Its use should obviate the adverse effects of fluorinated steroids.