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Biomedical subjects

A W Pound

Publications and source records attributed to A W Pound.

At least 37 records · Page 2Linked to original sources
PubMed1973

Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride.

Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours formed in the kidneys and the number in the liver was increased. When given after 60 hours, the incidence of kidney tumours was less but that of liver tumours was further increased. A larger dose of DMN (40 mg/kg) was tolerated 42 hours after CC1(4) and enhanced the number of kidney and liver tumours, the latter apparently due to an increased proportion of cholangiomata. Numerous small focal proliferations of atypical liver cells and of bile duct epithelium were observed after treatment with DMN. The incidence of these lesions in the different experimental treatments varied in a similar manner to the liver tumours.

Adenoma, Bile Duct↗
PubMed1972

Tumour formation in mice by urethane administered with related carbamates.

A tumour initiating dose of ethyl carbamate was administered to mice by subcutaneous injection together with a dose of one of the homologous esters or an ethyl N-alkyl derivative. The homologues used were the methyl, n-propyl and n-butyl esters, and the derivatives were the N-methyl, N-ethyl and N-n-propyl ethyl esters. The mice were then given promoting treatment with croton oil for 28 weeks.Neither the homologous esters nor the N-substituted derivatives of ethyl carbamate had any influence on the yield of tumours in the skin, lung, or liver. However, increasing the dose of ethyl carbamate increased the yields of tumours.

Animals↗