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Biomedical subjects

A W Ukich

Publications and source records attributed to A W Ukich.

5 recordsLinked to original sources

The effect of stopping smoking on blood pressure--a controlled trial.

Epidemiological studies have found evidence of lower blood pressure in smokers and predict an increase in blood pressure after stopping smoking. We have therefore monitored blood pressure change in 33 smokers following entry into a 6-week smoking cessation programme and compared the results to 33 matched controls who continued their normal smoking habits over the same period. Fourteen subjects were successful in quitting smoking for the entire 6 weeks, 13 were unsuccessful and 6 withdrew before completion of the programme. No significant increase in supine or erect systolic or diastolic blood pressure was observed following reduction in or cessation of smoking habit. Complete cessation of smoking was, however, associated with an increase in weight and anxiety levels and a decrease in alcohol consumption. We conclude that although stopping smoking affects several factors which may potentially influence blood pressure, this does not result in any significant change in blood pressure over a 6-week period. Concern that advice to patients to cease smoking may lead to a prompt increase in blood pressure appears unnecessary.

Adult↗

Smoking withdrawal programme: baseline indicators of smoking exposure and biochemical monitoring of successful outcome.

Sixty-four subjects who participated in a smoking withdrawal programme were analysed with respect to the relative usefulness of biochemical and hematological indices of smoking exposure. Plasma thiocyanate was found to be the best biochemical correlate of baseline cigarette consumption when compared to salivary thiocyanate or expired air carbon monoxide. Both plasma and salivary thiocyanate also correlated significantly with depth of inhalation per cigarette but not with any other questionnaire index of smoking exposure. After six weeks of successful smoking cessation all three indices fell significantly. Plasma thiocyanate proved the most sensitive biochemical index for monitoring ultimate outcome, accurately dichotomizing 90% of subjects as successful or unsuccessful in their attempts to stop smoking. The use of all three variables allowed accurate classification of 96% of subjects. White cell count, red cell count and hemoglobin also correlated significantly with baseline cigarette consumption and a significant decrease in these hematological indices occurred consequent to successful smoking cessation. However, these hematological changes were not as sensitive as biochemical indices in monitoring successful outcome.

Adult↗