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Biomedical subjects

A W Wilkinson

Publications and source records attributed to A W Wilkinson.

At least 19 recordsLinked to original sources

The urinary excretions of iron and chromium by children with burns and scalds.

There is a wide variation in the urinary output of chromium by children who have been burned or scalded. It seems possible that when the excretion of chromium is increased this may be related to an increased plasma concentration of glucose which may follow injury, and when the excretion of chromium is reduced this may be related to a low body content of chromium. During the first seven days after injury there is a significant increase in the excretion of iron. Likewise the iron/chromium ratio is also raised over the first seven days. The overall loss of iron during the first twelve days or thereabouts is probably not sufficient to require nutritional supplements over this period.

Burns

The excretion of alkaline ribonuclease by children undergoing surgery.

The excretion of alkaline ribonuclease has been measured in the urine of two groups of children after major operations. The excretion was significantly increased in all patients after open operations on the heart and in many of those who were operated on soon after birth for anomalies in the intestine. It is suggested that these elevations may indicate a disturbance of pancreatic function.

Cardiac Surgical Procedures

Metabolism of nicotinic acid in children with burns and scalds.

The excretions of two metabolites of nicotinic acid, N1-methylnicotinamide and N1-methyl-2-pyridone-5-carboxamide have been measured at varying times after injury in a group of 27 burned or scalded children. Compared with control patients the excretions of both of these metabolites were significantly raised after injury, which suggests that the utilisation of nicotinic acid is increased.

Burns

Why don't we prevent childhood accidents?

Accidental injury is the most important epidemic in the Western world today, and is especially important as a cause of death and disability in childhood. Many environmental factors are important causes of accidents, but there is no organisation within which doctors, official bodies, industry, and voluntary bodies can pool their experience and co-ordinate their efforts to reduce these environmental risks. A joint committee on childhood accident prevention should be formed in this country similar to that which exists in Sweden.

Accident Prevention

Splenogonadal fusion.

The fusion between splenic tissue and the left gonad or the derivatives of the left mesonephros is a rare congenital anomaly first described in detail by Pommer in 1887/9 and divided into two forms by Putschar and Manion in 1956. In the first or continuous type a cord of splenic or fibrous tissue connects the spleen and the gonadalmesonephric structures. In the second type the fused splenomesonephric structures have lost continuity with the main spleen. An example of the continuous form is presented and the previous reports are briefly reviewed.

Abnormalities, Multiple

Wound infection in a children's hospital.

The operation wounds of 20 per cent of the children operated on in one surgical unit of a children's hospital became infected. Infection was commonest in the newly born operated on as emergencies, 50 per cent of whose wounds became infected. No connection was found between injection and nasal carriage of staphylococci. A possible source of infection in the young may be the umbilicus.

Abdomen

Plasma biotin levels in children with burns and scalds.

The plasma concentrations of biotin were measured for up to 49 days after injury in nine children with burns and scalds which involved from 12% to 50% of the surface area of the body. Biotin levels below the minimum of the control range were observed in eight of the nine injured children at some stage during the episode.

Biological Assay

Plasma pyridoxal phosphate levels and tryptophan metabolism in children with burns and scalds.

Depression of the pyridoxal phosphate concentration in the plasma was observed in eight children after burning or scalding. The concentrations remained low for several weeks with the usual dietary supplements but could be restored rapidly with large doses of pyridoxine; this does not seem to alter the excretion of xanthurenic acid but causes an increased loss of kynurenic acid and kynurenine.

Burns

Zinc and copper urinary excretions in children with burns and scalds.

The daily urinary losses of zinc and copper have been measured over periods of up to 12 days following thermal injury in 18 children. Comparison with measurements of zinc and copper excretions in 35 control children showed that after injury by burning or scalding, the urinary excretions of both metals were increased in many of the patients. After severe injury, high urinary outputs of zinc and copper persisted for up to two months following injury.

Adolescent

Fetal surgery.

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Animals

Low birthweight babies with oesophageal atresia or tracheo-oesophageal fistula.

Of 142 patients of known gestation with oesophageal atresia or tracheo-oesophageal fistula, 21% were preterm with a mean weight of 2 kg, 19% were small-for-dates with a mean weight of 2.23 kg, and the remaining 60% were born at term and weighed more than 2.5 kg. There were almost five times as many preterm and almost eight times as many small-for-date infants as in a normal population. Respiratory distress syndrome and additional severe congenital anomalies were commoner in babies of short gestational age, and pneumonia was more common in small-for-dates babies.

Abnormalities, Multiple