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Biomedical subjects

A Waise

Publications and source records attributed to A Waise.

13 recordsLinked to original sources
PubMed2001

Which surrogate marker can be used to assess the effectiveness of the laboratory and its contribution to clinical outcome?

Assessment of the effectiveness of the clinical laboratory and its contribution to outcomes is gaining increasing emphasis, as part of the overall attempts at making clinical services more transparent and accountable. Tools traditionally used in the assessment of laboratory effectiveness and efficiency have included laboratory accreditation, Q-probes, performance in quality assurance programmes and staffing and cost issues. There is, however, a need to introduce different measures that highlight the laboratory efficiency and contribution to clinical effectiveness and outcomes. Such measures should, ideally, be quantifiable and evidence-based. The use of markers of efficiency and effectiveness could be used as tools to aid this process. Such markers could include incident reporting, the appropriateness of assay repertoire, adding value to reports, the quality of comments made, provision of information on the effect of analytical and biological variation on results, cascading requests to help making diagnoses and unearthing such diagnoses. We suggest that these measures contribute towards the implementation of the clinical governance agenda in relation to the laboratory, and could be used as indicators in laboratory accreditation.

Accreditation↗
PubMed1999

Clinical audit and the contribution of the laboratory to clinical outcome.

Medical and clinical audit are tools introduced in an attempt to assess clinical performance. Clinical audit implementation in practice should follow that of the audit and the learning cycles. Ideally, audit should assess the outcome of clinical care. However, many audit projects concentrate on the process of care, which is more amenable to review. One of the cornerstones of audit is the setting up of agreed standards of care. This takes the form of clinical practice guidelines derived, preferably from the outcome of randomised double-blind controlled trials as the basis of evidence-based medicine. The assessment of the contribution of the clinical laboratory to patient outcome could be seen as a further extension of clinical audit in the practice of laboratory medicine. Areas where this contribution may be assessed include validity and usefulness of diagnostic tests, the assessment of analytical goals in relation to patient outcome, variation in inter-laboratory performance and its effect on decision limits and whether any measurement or set of measurements contribute to improved outcome. The practice of clinical audit and the application of evidence-based medicine are seen as powerful educational tools, though there is much work to be done to assess their contribution to clinical outcome. Randomised clinical trials could form the basis for the assessment of the value and contribution of the laboratory to the outcome.

Evidence-Based Medicine↗
PubMed1989

Severe, self-limiting lactic acidosis and rhabdomyolysis accompanying convulsions.

A 26 year old man with no previous history of convulsions presented in status epilepticus and severe lactic acidosis. He regained consciousness and the acidosis resolved after several hours of conservative management without intravenous bicarbonate, but he developed severe myalgia associated with marked elevation of creatine kinase and moderate raised plasma creatinine levels which resolved spontaneously after 3 days. Severe lactic acidosis and rhabdomyolysis may accompany status epilepticus, although they appear to be self-limiting without important sequelae.

Acidosis, Lactic↗
PubMed1989

Pitfalls in the management of acute adrenocortical insufficiency: discussion paper.

In patients with acute adrenocortical insufficiency prompt recognition and treatment may be life-saving. Treatment should be initiated immediately before confirmation of the diagnosis. As shown by these case reports, junior staff on acute medical and surgical services, to whom these patients usually first present, may not appreciate that (a) hyponatraemia and hyperkalaemia, in the absence of renal failure, should immediately suggest the diagnosis of adrenal insufficiency and (b) treatment should precede confirmation of the diagnosis. Attempts to correct hyperkalaemia due to adrenocortical insufficiency with insulin and infusions of dextrose is inappropriate and potentially dangerous but seems to be a not unusual mistake.

Acute Disease↗