[Alteration of plasma lipoproteins in response to cholesterol feeding in the aged (author's transl)].
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Administration, Oral↗
Biomedical subjects
A Watabe
Publications and source records attributed to A Watabe.
[Various change of plasma lipoproteins in response to cholesterol load in man (author's transl)].
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Administration, Oral↗
Determination of benzo(a)pyrene in liquid paraffin by high performance liquid chromatography (HPLC).
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Benzopyrenes↗
[Case of chronic myeloleukemia associated with acute appendicitis and multople gastic ulcer].
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Acute Disease↗
[Metabolism of low fatty acids in chickens. Absorption of sodium acetate in the crop sac and cecum].
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Acetates↗
Gene delivery systems using the Sendai virus.
Fusogenic liposome (FL) is a delivery system that can transfer encapsulated materials into living cells directly through membrane fusion. FL is a promising approach for gene therapy because it can deliver various genetic materials much more efficiently than other non-viral vectors without damaging the cell. FL-mediated gene transfer consists of two independent membrane fusion phenomena; generation of a FL by fusing a Sendai virus (SV) particle with a simple liposome encapsulating DNA, and successive fusion of the FL with cell membrane. The former requires viral F protein but no other special molecule on the liposomal membrane, whereas the latter may require the receptor (sialic acid) and unidentified assistant molecule(s) on the cell membrane. Further analysis suggests that these assistant molecule(s), not the receptor, may control the fusion and govern the cell specificity of FL-mediated delivery. This review has described a detailed analysis of these fusion phenomena and discussed possible applications of FL-mediated gene delivery to human gene therapy.
Genetic Therapy↗