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Biomedical subjects

A Wedel

Publications and source records attributed to A Wedel.

30 records · Page 2Linked to original sources
PubMed1988

Mouse lysozyme M gene: isolation, characterization, and expression studies.

We have isolated and characterized both cDNA and genomic DNA of the mouse lysozyme M gene. Derivation of the amino acid sequence from the nucleotide sequences revealed six positions in the carboxyl terminus that differ from partial sequences previously published. The differential detection of specific mRNAs from the closely related lysozyme M and P genes has revealed different but overlapping tissue specificities of expression. The M gene is expressed weakly in myeloblasts, moderately in immature macrophages, and strongly in both mature macrophages and macrophage-rich tissues, while high levels of P transcripts are present only in small intestine. Sites of protein accumulation, rather than gene expression, have been identified by comparative quantitation of mRNA and enzyme levels.

Amino Acid Sequence↗
PubMed1988

Heterogeneity of patients with craniomandibular disorders. A longitudinal study.

The aim of this thesis was to investigate a consecutive series of patients with craniomandibular disorders (CMD), mainly functional disturbances of the masticatory system, in order to evaluate symptoms, the treatment outcome and the long-term prognosis in relation to different background factors. All 350 patients who came to a TMJ-clinic during a specific time period were included. 68% of the patients were women. The ages of the patients ranged between 12 and 80 years, with a mean of 39.9 years for the women and 38.3 for the men. At the first visit, the patients were given a self-administered questionnaire with 25 standardised questions. After 2 1/2 years, the records of the patients were examined for clinical findings, diagnoses and treatment. After about 4 years, a questionnaire, similar to the original one, was sent to a young and an old group of the patients to register present symptoms and need of treatment. Finally a clinical follow-up was performed in those who had reported that they wanted more treatment and, for comparison, in a group who had reported that they did not. The symptomatology was extremely varied in this group of 350 CMD patients. Headache, pain on mandibular movements and TMJ sounds were the most frequently reported symptoms. The significant correlation found between the severity of reported symptoms and the clinical dysfunction index (Di) was best explained by muscle tenderness on palpation. The dental status varied greatly among the patients and it was not significantly correlated to Di. The number of visits and length of the treatment period, factors that varied widely, were correlated to variables indicating severity of signs and symptoms at the first visit. Otherwise it was difficult to predict the treatment outcome, even when patients were divided into subgroups. Only one variable from the original questionnaire, duration of initial symptoms, and none from the first clinical examination, was significantly correlated to the treatment outcome at the 4-year follow-up. The mean number of days of sick-leave in the patients was correlated to Di, and it decreased after stomatognathic treatment. This series of studies has shown that patients with CMD are extremely heterogeneous in many respects, e.g. regarding symptoms, diagnosis and outcome of treatment.

Absenteeism↗
PubMed1987

Sick-leave in patients with functional disturbances of the masticatory system.

The number of days and periods of sick-leave in 350 consecutive patients were obtained from the National Health Insurance Service for the year of referral to a TMJ clinic and the following 4 years. As sick-leave varied greatly in the whole group, a subgroup of 157 patients with full sickness benefit was studied more closely. The mean number of days of sick-leave was correlated to the degree of mandibular dysfunction and decreased during the year after referral and the start of stomatognathic treatment. The reduction was greater in those with severer clinical dysfunction of the masticatory system at the first examination. The results indicate that there is an association between functional disturbances of the masticatory system and sick-leave. Stomatognathic treatment may therefore be of greater relative importance in the general health care system than is usually assumed.

Absenteeism↗
PubMed1986

A four-year follow-up, by means of a questionnaire, of patients with functional disturbances of the masticatory system.

From a group of consecutive patients referred for diagnosis and treatment of functional disturbances of the masticatory system, two groups, a young group (16-30 years, 113 subjects) and an older group (55-80 years, sixty-three subjects) were selected for a follow-up study. A self-administered questionnaire was mailed to them 4 years after the start of treatment. They had answered a similar questionnaire at the first visit. Of the selected patients, 148 (84%) participated. If explainable losses are excluded, the response rate was 89%. Most of the pain and dysfunction symptoms had diminished significantly in frequency while 'peripheral' symptoms such as tinnitus, vertigo, tongue pain and swallowing difficulties had the same prevalence on both occasions. Two-thirds of the patients reported a positive effect of treatment, without any significant difference between the younger and the older group. The remaining symptoms differed, however. The older group reported pain in the face and jaws, vertigo, tinnitus, tongue pain and TMJ crepitation more often than the younger group, while the opposite was found for TMJ clicking and tooth grinding. Only one variable from the original questionnaire (duration of initial symptoms), with none from the first clinical examination, was significantly correlated to the retrospective assessment of treatment outcome. This shows that it is difficult to predict the long-term outcome of treatment from data collected at the first examination of a patient with TMJ pain and dysfunction, but that a long duration of symptoms may have a negative influence on the prognosis.

Adolescent↗
PubMed1985

Factors influencing the outcome of treatment in patients referred to a temporomandibular joint clinic.

A retrospective review was performed in 350 consecutive patients referred for functional disturbances of the masticatory system. Two and one-half years after the first visit, the records of all patients were examined for clinical findings, diagnosis, and observations related to treatment. Number of visits, length of the treatment period, and evaluation of signs and symptoms at last visit (factors which showed a wide variation) were analyzed for correlation with signs and symptoms at first visit and some background factors. A total of 50 variables were considered. The number of visits and length of treatment indicated the severity of signs and symptoms at the first visit. Multiple regression analysis showed that tenderness on muscle palpation at first visit was the most important of the independent variables. About one-fourth of the variance of number of visits and length of treatment could be explained (R2 = 0.28 and 0.27, respectively), while the corresponding value for the variance of the evaluation at last visit was 15% (R2 = 0.15). The results tend to emphasize the heterogeneity of patients with functional disturbances of the masticatory system and the difficulty of prognosticating the outcome of treatment in such patients, even when attempts are made to divide them into subgroups.

Adult↗
PubMed1983

Retrospective review of 350 patients referred to a TMJ clinic.

The records of 350 consecutive patients referred 2 1/2 years previously were examined retrospectively for clinical findings, diagnoses and observations related to treatment. There was a good correlation between the severity of symptoms reported by the patients in a questionnaire at the first visit and the clinical dysfunction index. The female patients had higher dysfunction index values than the men, while the occlusal index was equally distributed in both sexes. The most frequently used treatment methods were bite planes, occlusal adjustment and jaw exercises. There was a wide variation in the length of the treatment period and number of visits but the median values for these variables were 3 and 4 months, respectively, which is encouraging in view of the fact that the duration of the symptoms before the start of treatment was more than 6 months in two-thirds of the patients. Patients who had reported severe symptoms and those who were in a "poor social situation" had higher clinical dysfunction index values at the first visit, had more visits to the clinic and required a longer treatment period than others but they did not differ regarding the evaluation of the clinical situation at termination of treatment.

Adult↗
PubMed1982

Analysis of background variables in 350 patients with TMJ disorders as reported in self administered questionnaire.

All 350 patients referred to the Department of Stomatognathic Physiology during a 4-month period were given a self-administered questionnaire intended to give a review of the patients' history. The questions concerning general somatic and psychic health, education and social conditions are dealt with in this article. Twenty-five percent of the patients, more women than men, considered their general state of health to be impaired or poor. Seventy-two percent of the patients denied having had nervous or psychic disorders while 9% were currently being treated for such symptoms. Patients who had answered with alternatives indicating a "poor social situation" had, for instance, more pain in the face and jaws, poorer general health, more nervous or psychic disorders and more symptoms of TMJ disorders than the other patients. When the influence of education was considered, the patients with low education reported more severe symptoms of TMJ disorders than those with higher education. The general level of somatic and psychic health of the patients in this study did not differ markedly from that of the general population, but a negative influence on the health of the masticatory system of poor social conditions and low educational level could be demonstrated.

Adolescent↗