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Biomedical subjects

A Wee

Publications and source records attributed to A Wee.

At least 91 records · Page 5Linked to original sources
PubMed1985

Primary hepatocellular carcinoma associated with Wilson's disease in a young woman.

A 27 year old woman with hepato-lenticular degeneration (Wilson's disease) was found to have primary hepatocellular carcinoma (PHC) three and a half years after she was started on treatment with D-penicillamine. The tumour was resected since when she has remained well. Her liver function tests were normal throughout the course of her disease. The available literature is reviewed and possible mechanisms for this association proposed.

Adult↗
PubMed1985

Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts?

Review of liver biopsy specimens, autopsy specimens, and clinical records of 107 patients with chronic ulcerative colitis and hepatobiliary diseases showed "pericholangitis" (defined as small-duct primary sclerosing cholangitis) in 37 (35%), primary sclerosing cholangitis (defined as large-duct primary sclerosing cholangitis) in 18 (17%), chronic active hepatitis in 14 (13%), cryptogenic cirrhosis in 12 (11%), and miscellaneous lesions including malignancies in 26 (24%). Documented cirrhosis was present or developed in 37 patients (35%). The spectrum of histologic features of small-duct primary sclerosing cholangitis was indistinguishable from that of confirmed large-duct primary sclerosing cholangitis. In 6 of the 18 patients who eventually developed the large-duct disease, biopsy evidence 1 to 12 years earlier had shown small-duct primary sclerosing cholangitis. Thus, small-duct and large-duct primary sclerosing cholangitis seem to be components of a disease spectrum.

Bile Ducts, Intrahepatic↗
PubMed1985

Tumoral calcinosis--a case report.

Tumoral Calcinosis is a well established but rare clinical entity. It was first described in 1899, and since then, scattered reports have occurred in the literature from many parts of the world. The main controversy lies in the aetiology of the condition. One such case is presented in this paper, along with a review of the literature.

Calcinosis↗
PubMed1985

Thrombotic complication of umbilical arterial catheterization and its sequelae.

Umbilical arterial catheterization caused major complications including 5 deaths in 25 of 230 infants who underwent autopsy at the Kandang Kerbau Hospital in a two-and-a-half year period beginning May 1982. Arterial thrombosis developed in 25 of 129 (19.3%) autopsies with a history of umbilical arterial catheterization. Pathological sequelae of thrombosis occurred in 14 cases (peripheral gangrene 1, renal 6, gastrointestinal 3 and both renal and gastro-intestinal 4). The sequelae were clinically unsuspected in the majority. Early deaths were uncommon in the group with thrombosis. Comparison of neonatal factors revealed no significant differences between the group with sequelae and those without. Infants with indwelling umbilical arterial catheter should be actively monitored for complications.

Aorta, Abdominal↗
PubMed1984

Intestinal lymphangiectasia--a report in two Chinese children.

Two Chinese infants with asymmetrical lymphoedema and steatorrhoea were investigated. The laboratory investigations showed that they had hypoproteinaemia without proteinuria. One of them showed peripheral lymphopenia and hypogammaglobulinaemia. Radiologically, they had evidence of extensive lymphangiectasia of the small intestine. This was confirmed histologically. Endoscopy of one of them showed diffuse milky nodular duodenal mucosa. The appearance of the mucosa was rather typical of intestinal lymphangiectasia.

Endoscopy↗
PubMed1983

Gastritis and duodenitis--a clinical, endoscopic and histological study and review of the literature.

A clinical, endoscopic and histological study of gastritis and duodenitis was carried out in 50 patients. The endoscopic diagnosis of mucosal inflammation was found to be highly reproducible. However there was poor correlation between endoscopic and histological diagnoses of gastritis or duodenitis. Neither endoscopic nor histological gastritis or duodenitis correlated with symptoms. These findings are in agreement with others reported in the literature. Gastritis and duodenitis should not be diagnosed by history alone but only by endoscopy or histology. When gastritis or duodenitis is the only pathology demonstrated only symptomatic therapy should be given. The literature on the diagnosis and aetiology of gastritis as well as that of specific varieties of gastritis is reviewed.

Adult↗
PubMed1982

Congenital cytomegalovirus infection.

Three cases of overt congenital cytomegalovirus infection, each with a different mode of presentation, are documented. Common features of presentation were hepatosplenomegaly, skin petechiae, neonatal jaundice and gross hepatic dysfunction. One infant presented with hydrops fetalis, a feature not described before. Two infants survived and are at present developing normally.

Cytomegalovirus Infections↗
PubMed1979

Infantile fibrosarcoma: report of cases.

Infantile "fibrosarcoma" occurred in a newborn male infant and in a 2-month-old female infant. In both cases, the tumors grew rapidly and showed the histological features of malignancy. However, they were treated successfully with simple resections. Review of the literature shows that infantile fibrosarcoma has a relatively favorable prognosis. Simple local excision is the initial treatment of choice for lesions occurring in infants and children less than 5 years old.

Female↗
PubMedDate not supplied

Low-dose cimetidine in the acute treatment of duodenal ulcer. Comparison of a single nocturnal dose regimen with a twice daily regimen.

A 0.5 g daily dose of cimetidine was as effective as a 1 g dose in the acute treatment of duodenal ulcer patients in Hong Kong. The aims of the present study were, first, to determine whether low-dose cimetidine treatment was as effective as standard doses in acute duodenal ulcer treatment of patients in Singapore, and second, to compare a single nocturnal dosage regimen with a twice daily regimen. In this single centre, double-blind, controlled trial, 282 patients with endoscopically proven duodenal ulcer were randomized to receive four weeks' treatment with cimetidine using one of three dosage regimens: (A) 800 mg at night; (B) 400 mg at night; or (C) 400 mg twice daily. Two hundred and forty-seven patients were evaluated. The incidences of healing at four weeks were: (A) 40/80 (50%), (B) 39/88 (44%); and (C) 48/79 (61%); (B vs C: P less than 0.05; A vs C: NS; 95% confidence limits: -5% to 27%; A vs B: NS, 95% confidence limits: -6% to 21%). Of 183 patients who had antral biopsies taken, 176 (96%) had histological gastritis, while 167 (91%) were positive for Helicobacter-like organisms. The occurrence of gastritis or Helicobacter-like organisms had no influence on ulcer healing. A 400 mg dose of cimetidine is therefore suboptimal for the treatment of duodenal ulcer in patients in Singapore. A single nocturnal dosage regimen may be less effective than a twice daily regimen.

Adult↗