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A Weeks

Publications and source records attributed to A Weeks.

17 recordsLinked to original sources
PubMed2006

Overview of active personal dosemeters for individual monitoring in the European Union.

In 2001, the European Radiation Dosimetry Group, EURADOS, started a working group on 'Harmonisation of Individual Monitoring in Europe and the Dissemination of Information on New Techniques in this Field'. Within this group, one of the projects consisted of analysing the status of active personal dosemeters (APDs) in Europe. This paper reviews the regulatory requirements for APDs in 15 EU member states and summarises the main characteristics of commercial and new developments in this field. In particular, it focuses on the comparison of APD performance and standard passive dosimetry systems. Based on this information, an evaluation is initiated to establish why several countries are reluctant to accept APDs for dose records.

Environmental Exposure↗
PubMed2006

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples.

Adolescent↗
PubMed2006

Oral misoprostol for induction of labour.

BACKGROUND: Misoprostol is a synthetic prostaglandin that can be given orally or vaginally. In most countries misoprostol has not been licensed for use in pregnancy, but its unlicensed use is common because misoprostol is cheap, stable at room temperature and effective in causing uterine contractions. Oral use of misoprostol may be convenient, but high doses could cause uterine hyperstimulation and uterine rupture which may be life-threatening for both mother and fetus. OBJECTIVES: To assess the effectiveness and safety of oral misoprostol used for labour induction in women with a viable fetus in the third trimester of pregnancy. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group Trials Register (January 2005). SELECTION CRITERIA: Randomised trials comparing oral misoprostol versus other methods, placebo or no treatment, given to women with a viable fetus for labour induction. DATA COLLECTION AND ANALYSIS: Three authors independently assessed trial quality and extracted data, using centrally-designed data sheets. MAIN RESULTS: Forty-one trials (8606 participants) were included. In four trials comparing oral misoprostol with placebo (474 participants), women using oral misoprostol were less likely to have long labours (relative risk (RR) 0.16, 95% confidence interval (CI) 0.05 to 0.49), needed less oxytocin (RR 0.32, 95% CI 0.24 to 0.43) and had a lower caesarean section rate (RR 0.62, 95% CI 0.40 to 0.96). In nine trials comparing oral misoprostol with vaginal dinoprostone (2627 participants), women given oral misoprostol were less likely to need a caesarean section, but this reduction reached statistical significance only in the subgroup with intact membranes (RR 0.78, 95% CI 0.66 to 0.94). Uterine hyperstimulation was more common after oral misoprostol (RR 1.63, 95% CI 1.09 to 2.44) although this was not associated with any adverse fetal events. Seven trials (1017 participants) compared oral misoprostol with intravenous oxytocin. The only difference between the groups was an increase in meconium-stained liquor in women with ruptured membranes following administration of oral misoprostol (RR 1.72, 95% 1.08 to 2.74). Sixteen trials (3645 participants) compared oral and vaginal misoprostol and found no difference in the primary outcomes. There was less uterine hyperstimulation without fetal heart rate changes in those given oral misoprostol (RR 0.37, 95% 0.23 to 0.59). Oral misoprsotol was associated with increased need for oxytocin augmentation (RR 1.28, 95% 1.11 to 1.48) and more meconium-stained liquor (RR 1.27, 1.01 to 1.60). AUTHORS' CONCLUSIONS: Oral misoprostol appears to be more effective than placebo and at least as effective as vaginal dinoprostone. However, there remain questions about its safety because of a relatively high rate of uterine hyperstimulation and the lack of appropriate dose ranging studies. In countries where misoprostol remains unlicenced for the induction of labour, many practitioners will prefer the legal protection of using a licenced product like dinoprostone. There is no evidence that misoprostol given orally is inferior to the vaginal route and has lower rates of hyperstimulation. If misoprostol is used orally, the dose should not exceed 50 mcg.

Administration, Oral↗
PubMed2006

Aspects of harmonisation of individual monitoring for external radiation in Europe: conclusions of a EURADOS action.

Following the publication of the EU Council Directive 96/29, EURADOS coordinated two working groups (WGs) for promoting the process of harmonisation on individual monitoring of occupationally exposed persons in Europe. An overview of the major findings of the second WG is presented. Information on the technical and quality standards and on the accreditation and approval procedures has been compiled. The catalogue of dosimetric services has been updated and extended. An overview of national regulations and standards for protection from radon and other natural sources in workplaces has been made, attempting to combine the results from individual monitoring for external, internal and workplace monitoring. A first status description of the active personal dosemeters, including legislative and technical information, and their implementation has been made. The importance of practical factors on the uncertainty in the dose measurement has been estimated. Even if a big progress has been made towards harmonisation, there is still work to be done.

Europe↗
PubMed2004

Active personal dosemeters for individual monitoring and other new developments.

In this paper, we will present a first (but not complete) status description of active personal dosemeters (APDs) and their implementation in European countries. In modern radiation protection practices, APDs are becoming absolutely necessary operational tools for satisfying the ALARA principle. Despite their success, they are relatively new for individual monitoring of workers. Regulation, legal requirements and calibration procedures are different in European member states. A catalogue of commercially available and prototype devices is presented. Improvement on devices and in implementation of calibration method are expected in the forthcoming years. End-user feedback experience and requirements are reported.

Body Burden↗
PubMed2002

Within- and between-population variation for Wolbachia-induced reproductive incompatibility in a haplodiploid mite.

Wolbachia pipientis is a bacterium that induces cytoplasmic incompatibility (CI), the phenomenon in which infected males are reproductively incompatible with uninfected females. CI spreads in a population of hosts because it reduces the fitness of uninfected females relative to infected females. CI encompasses two steps: modification (mod) of sperm of infected males and rescuing (resc) of these chromosomes by Wolbachia in the egg. Infections associated with CI have mod+ resa+ phenotypes. However, mod- resc+ phenotypes also exist; these do not result in CI. Assuming mod/resc phenotypes are properties of the symbiont, theory predicts that mod- resc+ infections can only spread in a host population where a mod+ resc+ infection already occurs. A mod- resc+ infection spreads if the cost it imposes on the infected females is lower than the cost inflicted by the resident (mod+ resc+) infection. Furthermore, introduction of a mod- Wolbachia eventually drives infection to extinction. The uninfected population that results can be recolonized by a CI-causing Wolbachia. Here, we investigated whether variability for induction of CI was present in two Tetranychus urticae populations. In one population all isofemale lines tested were mod-. In the other, mod+ resc+ and mod- resc+ isofemale lines coexisted. We found no evidence for a cost difference to females expressing either type (mod-/-). Infections in the two populations could not be distinguished based on sequences of two Wolbachia genes. We consider the possibility that mod- is a host effect through a population dynamics model. A mod- host allele leads to infection extinction in the absence of fecundity differences. Furthermore, the uninfected population that results is immune to reestablishment of the (same) CI-causing Wolbachia.

Animals↗
PubMed2001

Parent-based therapies for preschool attention-deficit/hyperactivity disorder: a randomized, controlled trial with a community sample.

OBJECTIVE: To evaluate two different parent-based therapies for preschool attention-deficit/hyperactivity disorder (ADHD) in a community sample. METHOD: Three-year-old children displaying a preschool equivalent of ADHD (n = 78) were randomly assigned to either a parent training (PT; n = 30), a parent counseling and support (PCO&S; n = 28), or a waiting-list control group (n = 20). The PT group received coaching in child management techniques. The PC&S group received nondirective support and counseling. Measures of child symptoms and mothers' well-being were taken before and after intervention and at 15 weeks follow-up. RESULTS: ADHD symptoms were reduced (F2,74 = 11.64; p < .0001) and mothers' sense of well-being was increased by PT relative to both other groups (F2,74 = 10.32; p < .005). Fifty-three percent of children in the PT group displayed clinically significant improvement (chi 2 = 4.08; p = .048). CONCLUSIONS: PT is a valuable treatment for preschool ADHD. PC&S had little effect on children's behavior. Constructive training in parenting strategies is an important element in the success of parent-based interventions. Psychostimulants are not a necessary component of effective treatment for many children with preschool ADHD.

Attention Deficit Disorder with Hyperactivity↗
PubMed1998

Clinically oriented pharmacy technicians to augment clinical services.

The justification for and the training, responsibilities, and contributions of two clinically oriented pharmacy technicians are described. A proposal outlining the clinical services being provided by pharmacists at a 650-bed medical center and the need for technical assistance was developed and approved. Two clinical technician positions were created to replace one of two eliminated pharmacist positions. Each of the technicians hired had worked successfully in several traditional pharmacy technician roles. The technicians were trained for specific roles and cross-trained in the basic functions of each other's roles. The technicians made rounds with the pharmacists to learn how to evaluate patients and interact with physicians and nurses and were required to demonstrate competence in deciding which patients required further evaluation. One technician focuses on providing direct clinical service support, and the other works primarily as a clinical administrative assistant. Half the technicians' time is spent performing services previously performed by pharmacists. In addition, the technicians track outcomes and provide clerical and data-management assistance. The technicians are responsible for screening and tracking approximately 400 patients per month on well-established services and 400 per month on two new monitoring services. The technicians have helped develop a medication-error tracking program. Clinically oriented technicians freed up pharmacists' time by collecting routine clinical data and managing clinical projects; through protocol-based screening and outcomes tracking, the technicians have helped to implement new clinical services and evaluate existing ones.

Hospital Bed Capacity, 500 and over↗
PubMed1981

Socialisation scheme with a high staff-patient ratio.

Six months after a comprehensive socialisation scheme began, a prospective controlled study was carried out. The patients were tested in three practical sections - Cooking; Maintenance of Home and Clothing; Other Skills (eg. form-filling); and with a Questionnaire. Forty-eight members of an experimental group received socialisation training after initial testing. They and the 20 controls who did not undergo training were re-evaluated three months later. There was no significant difference between the groups in their initial scores. On retesting, the experimental group showed a significant improvement in Cooking (p less than 0.001), Home Maintenance (p less than 0.001) and the Questionnaire (p less than 0.05). Analysis of the inter-group differences showed significant superiority of the experimental group in Cooking (p less than 0.05) and Home Maintenance (p less than 0.05). It is suggested that such a socialisation scheme be considered for inclusion alongside other rehabilitation services in psychiatric hospitals. The emphasis on a high staff-to-patient ratio and the breakdown of each task into smaller steps emerged as essential elements in the training programme.

Activities of Daily Living↗
PubMedDate not supplied

Behaviour modification in hyperactive children.

Behaviour problems in pre-school children can be significantly improved by professionals experienced in child behaviour modification techniques. Reported disobedience, temper tantrums and poor concentration in hyperactive children aged three to three-and-a-half years improved significantly in a treatment group, following eight home visits by research health visitors working in a child and family guidance service.

Attention Deficit Disorder with Hyperactivity↗