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Biomedical subjects

A Wehrli

Publications and source records attributed to A Wehrli.

6 recordsLinked to original sources
PubMed1986

One name only.

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Legislation, Drug↗
PubMed1982

The influence of beta-adrenoceptor blocking drugs with and without intrinsic sympathomimetic activity on the hormonal responses to hypo- and hyperglycaemia.

1 The effects of oral doses of pindolol (15 mg), metoprolol (200 mg) and propranolol (160 mg) on the response to insulin-induced hypoglycaemia and an oral glucose load were investigated. 2 Serum insulin and serum C-peptide secretion in response to a glucose load were inhibited (2P less than 0.01) by metoprolol and propranolol but not by pindolol. 3 During hypoglycaemia metoprolol and propranolol inhibited the clearance of insulin (2P less than 0.01) and caused a delay of glucose nadirs. 4 Adrenaline secretion during hypoglycaemia was markedly increased by metoprolol and propranolol but not by pindolol. 5 The counterregulatory response of growth hormone, ACTH and cortisol was increased following metoprolol and propranolol but not after pindolol. 6 The hypoglycaemic symptoms and signs showed a prevalence of sweating and prolonged changes in skin conductivity whereas palpitations were not observed during beta-adrenoceptor blockade. Asymptomatic hypoglycaemia did not occur. 7 The absence of unphysiological rises in adrenaline, growth hormone, ACTH and cortisol supports the use of a beta-adrenoceptor blocker with intrinsic sympathomimetic activity.

Adrenergic beta-Antagonists↗
PubMed1976

[Neuropsychological examinations in childhood].

Three groups of children aged 8-12 years have been investigated by a test battery to gain insight into the problems surrounding the relationship between cerebral and behavioral development. One group was of children with circumscribed cortical lesions, one was a group of dyslexics with neurologic anomalies, and the third was a control group of children without brain lesions. General test intelligence did not differ significantly in the three groups. Marked differences between the various lesion groups are observable in some tests but not in others. For example, the results of children with left temporal lesions in the verbal part of the intelligence test and in fresh language memory were inferior to those of all other lesion groups and the controls, while the dyslexics showed a similar if less marked deficit. Non-linguistic (figural) memory did not differ as between groups. On the other hand, children with right frontal lesions were notable for inferior results in a visual learning test and a classification test. In a linguistic-dichotic test all the groups of brain lesions and the dyslexics differed from the control group, a fact which suggests retarded development of hemispheric dominance for speech functions. From these provisional results it can be concluded that the brain areas do not all specialize simultaneously, and that compensation of cerebral lesions in relation to different functions probably results in retardation of overall brain development and anatomico-functional specialization.

Age Factors↗