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Biomedical subjects

A Weingarten

Publications and source records attributed to A Weingarten.

13 recordsLinked to original sources
PubMed2006

The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration.

The purpose of this study was to determine the pharmacokinetics and physicochemical characteristics of orbifloxacin in the horse. Six healthy adult horses were administered oral and intravenous orbifloxacin at a dose of 2.5 mg/kg. Plasma samples were collected and analyzed by high-pressure liquid chromatography with ultraviolet detection. Plasma protein binding and lipophilicity were determined in vitro. Following i.v. administration, orbifloxacin had a terminal half-life (t1/2) of 5.08 h and a volume of distribution (V(d(SS))) of 1.58 L/kg. Following oral administration, the average maximum plasma concentration (Cmax) was 1.25 microg/mL with a t1/2 of 3.42 h. Systemic bioavailability was 68.35%. Plasma protein binding was 20.64%. The octanol:water partition coefficient (pH 7.4) was 0.2 +/- 0.11. No adverse reactions were noted during this study. Dosage regimens were determined from the pharmacokinetic-pharmacodynamic parameters established for fluoroquinolone antibiotics. For susceptible bacteria, an oral dose of approximately 5 mg/kg once daily will produce plasma concentrations within the suggested range. This dose is suggested for further studies on the clinical efficacy of orbifloxacin for treatment of susceptible bacterial infections in the horse.

Administration, Oral↗
PubMed2001

Ion separation due to magnetic field penetration into a multispecies plasma.

The magnetic field, the electron density, and the ion velocities in a multispecies plasma conducting a high fast-rising current are determined using simultaneous spectroscopic measurements. It is found that ion separation occurs in which a light-ion plasma is pushed ahead while a heavy-ion plasma lags behind the magnetic piston. We show that most of the momentum imparted by the magnetic field pressure is taken by the reflected light ions, and most of the dissipated magnetic field energy is converted into kinetic energy of these ions, even though their mass is only a small part of the total plasma mass. Such species separation with implications to the momenta and energy partitioning is shown to be of a general nature.

Journal Article↗
PubMed1995

Treatment of keratoconjunctivitis sicca in dogs with cyclosporine ophthalmic ointment: a European clinical field trial.

The results are reported of a six-week clinical trial of the efficacy of 0.2 per cent cyclosporine ophthalmic ointment for the treatment of chronic idiopathic keratoconjunctivitis sicca in dogs in the United Kingdom, Germany and France. The 87 dogs were referral cases with a history of chronic unresponsive keratoconjunctivitis sicca of which the aetiology was unknown, and they had to meet stringent criteria before being included in the trial. The clinical response to the therapy was monitored after seven, 21 and 42 days and the results for the right and left eyes were analysed separately. There was a statistically significant increase in lacrimal secretion throughout the study, with most of the increase occurring during the first week of treatment. The percentage of eyes with improved lacrimal secretion was higher in the dogs with initial Schirmer tear test values > or = 2 mm/min than in those with initial values of 0 or 1 mm/min. The observed steady improvement in conjunctival health was not always correlated with an improvement in lacrimal secretion. The incidence of blepharospasm, other signs of discomfort and corneal oedema decreased significantly during the study. No improvement in corneal vascularisation or pigmentation was observed during the six-week trial. Overall, 76 per cent of the left eyes and 87 per cent of the right eyes were considered to have improved at the end of the treatment period. No serious adverse reactions were observed and only mild irritation was noticed by the owners immediately after the application of the ointment. This irritation resulted in the recording of an adverse reaction at the scheduled observations in only three cases.

Animals↗
PubMed1978

[Hepatic arterial embolisation. 35 cases (author's transl)].

Thirty five cases of hepatic arterial embolisation are reported. The analgesic effect in association with tumour pathology (27 cases) was virtually constant (80% of cases). Arterial embolisation should thus replace surgical disarterialisation in the management of malignant tumours of the liver. It improves the quality of survival in painful tumours, above all when they are hypervascularised. Two fatal complications as a result of the technique emphasise the absolute need to respect its contraindications: portal thrombosis, even segmental, or hepatic failure. Two cavernous haemangiomas and one angioma with arterioportal fistula complicated by haemobilia were also successfully embolised. Five traumatic vascular lesions, two of which resulted in severe haemobilia, also benefited from superselective embolisation.

Arteriovenous Fistula↗
PubMedDate not supplied

[Antimalaria campaign in the Middle-east army (1917): the illustrated postcard as a means of information and propaganda by pictures].

The authors take out from oblivion the series of illustrated post-cards published in 1917 by the French under-secretariat of state for Military Health Service in order to promote the malaria control within the Middle-East French Army. They give some details on how these post-cards were originated, they also illustrate some principles of prevention against malaria made compulsory for the Armed Forces Personnel. The authors also demonstrate how that simple and easy to handle medium, fast vector of sanitary information, was able to support effectively the antimalaria Mission in the Middle-East French Army in its malaria prophylactic action.

Audiovisual Aids↗
PubMedDate not supplied

[Highly selective arteriography and embolization in the treatment of angiodysplasias with shunt, in the limbs (author's transl)].

The authors discuss the role of highly selective arteriography and embolization in the treatment of angiodysplasias with shunt, in the limbs, after analyzing the results in three cases of embolization for congenital arterio-venous fistula of the limbs. They review the arteriographic data necessary for a better understanding of the physiopathology and compare the different therapeutic methods available. The importance of highly selective arteriography in guiding therapy, where embolization is of primary value, is stressed.

Adult↗