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Biomedical subjects

A Weissmann

Publications and source records attributed to A Weissmann.

26 records · Page 2Linked to original sources
PubMed1980

Photochemotherapy of psoriasis: effects on bacteria and surface lipids in uninvolved skin.

The effect of PUVA therapy for psoriasis on the microbial flora and on levels and composition of skin surface lipid has been studied in ten patients. Samples were obtained from clinically uninvolved skin from the back and the forearm. There was no consistent significant change in the viable counts of aerobic cocci or anaerobic coryneforms during theraapy. A transient rise in Staphylococcus aureus counts was thought to be due to the use of emollients rather than no effect of PUVA. Genetic changes in the microorganisms were not sought. There was an increase in the amount of total lipid (both casual levels and replacement sums) during therapy. An increase of free fatty acids at the expense of triglycerides did not reach statistical significance. The influence of PUVA on the skin flora seems to be less in vivo than anticipated from in vitro studies.

Adult↗
PubMed1979

Quantitative thin layer chromatography for the analysis of skin surface lipids. A time-saving method using a new TLC plate.

Recently a new thin layer chromatography plate (Whatman LK 6D) became available which is extremely easy to handle and permits highly reproducible qualitative and quantitative analysis. This plate proved to be of great value for the investigation of skin surface lipids. The use of a fatty acid methyl ester as an internal standard makes it unnecessary to employ additional gravimetrical or photometrical methods for quanitative lipid analysis. The method presented in this paper is simpler and requires much less time than alternative procedures and allows a large number of lipid samples to be processed simultaneously.

Chromatography, Thin Layer↗
PubMed1977

Prolactin: a diabetogenic hormone.

During an oral glucose tolerance test (OGTT) glucose and insulin levels were measured in 26 patients with prolactin-producing pituitary tumours without growth hormone excess. Basal glucose and insulin levels did not differ from the values of an age-matched control group. After glucose load the hyperprolactinaemic patients showed a decrease in glucose tolerance and a hyperinsulinaemia. Bromocriptine (CB 154), which suppressed PRL, improved glucose tolerance and decreased insulin towards normal in second OGTT. Human PRL or CB 154 had no significant influence on insulin release due to glucose in the perfused rat pancreas. These findings suggest a diabetogenic effect of PRL. CB 154 might be a useful drug in improving glucose utilization in hormone-active pituitary tumours.

Adenoma↗