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Biomedical subjects

A Wenzel

Publications and source records attributed to A Wenzel.

At least 145 records · Page 8Linked to original sources
PubMed1984

Dental health status and attitudes to dental care in families participating in a Danish fluoride tablet program.

The caries experience and dental fluorosis of 84 Danish children, who had used fluoride tablets for 1-4 yr in the period 1976-80, were compared with those of a group matching in sex, age, place of living, and socioeconomic status. The average age of the children at the time of examination was 5.8 yr. A recording of mothers' attitudes to dental care, knowledge about tooth brushing, attitudes to candy, and number of teeth in the maxilla showed no difference between the fluoride tablet group and the non-users' group. Moreover, there was no significant difference between the two groups with respect to dental caries. The findings are discussed in relation to recent reports on the decline of dental caries resulting from widespread use of local administration of fluorides.

Adult↗
PubMed1984

Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma.

The effect of intranasally administered corticosteroid (budesonide) on nasal symptoms, mode of respiration (nasal versus mouth breathing), and asthma was investigated in 37 asthmatic children who were mouth breathers because of chronic nasal obstruction. After a 2-wk run-in period, the children were allocated randomly to 4 wk of intranasal therapy with either budesonide (400 micrograms/day) or placebo spray. A double-blind, parallel design was used. Diaries for peak expiratory flow, asthma, and rhinitis symptom scores and degree of mouth breathing were recorded at home. Nasal eosinophilia, nasal airway resistance at a flow of 0.2 L/s (NAR0.2), and lung function at rest and after exercise challenge were assessed at the clinic immediately before and at end of the 4-wk treatment. Budesonide, when compared with placebo, significantly decreased nasal obstruction (p less than 0.05), secretion (p less than 0.01), and eosinophilia (p less than 0.02), as well as NAR0.2 (p less than 0.05) and mouth breathing (p less than 0.01). The improvement in nasal obstruction correlated closely to the changes in mouth breathing (r = 0.80, n = 17, p less than 0.001). Furthermore, intranasally administered budesonide resulted in less exercise-induced asthma (EIA) (p less than 0.02) and decreased cough and asthma severity significantly. Pulmonary mechanics were only marginally improved. The present study showed that intranasally administered budesonide is effective in the treatment of perennial allergic rhinitis. An attenuation of EIA and a tendency to less asthma after budesonide therapy suggest a decrease in bronchial reactivity, but the results gave no clear evidence of an association between nasal airway function and asthma.

Administration, Intranasal↗
PubMed1983

Nasal respiratory resistance and head posture: effect of intranasal corticosteroid (Budesonide) in children with asthma and perennial rhinitis.

The influence of mouth breathing on craniofacial development has previously been demonstrated. Recent investigations do indicate, however, that head posture also might be related to craniofacial morphology. The aim of the present study was to analyze the effect of a topical steroid spray (Budesonide) on nasal respiratory resistance and head posture in children with asthma and nasal obstruction. Thirty-seven children, 8 to 15 years of age, with bronchial asthma, perennial allergic rhinitis, and subjectively assessed mouth breathing were selected for the study. Rhinomanometric and cephalometric analyses were performed. Head posture was defined as the position of the head relative to the cervical column and to the true vertical. After the first examination the children were randomly allocated to two groups, of which one group was treated intranasally with Budesonide (N = 18) and the other with placebo (N = 19), for a double-blind study. After one month of treatment, there was a statistically significant decrease in nasal resistance (p less than 0.001) and an increased flexing of the head (p less than 0.01) (paired t tests) in the children under active treatment. No significant changes were seen in the placebo group. The results indicate that Budesonide nasal spray is capable of reducing nasal obstruction in allergic children and that a reduced nasal resistance leads to a decrease in craniocervical angulation. The clinical importance of these results is yet to be clarified.

Adolescent↗
PubMed1982

The relationship between water-borne fluoride, dental fluorosis and skeletal development in 11-15 year old Tanzanian girls.

Dental fluorosis was evaluated by a classification system, previously shown to be sensitive, and skeletal changes evaluated by bone maturity and structure. Dental fluorosis was more severe in posterior than in anterior teeth in both jaws irrespective of fluoride concentration of the drinking water. There appeared to be no dependence between fluoride content of the water and skeletal maturity or structure, but there was a definite relationship between the degree of dental fluorosis and skeletal maturity within the high fluoride area. Fluoride concentrations in the drinking water above 3 parts/10(6) seemed to affect all mineralizing tissues under formation. The unique pattern of enamel formation and mineralization renders it the only hard tissue which permits an early diagnosis of the biological effect of even low fluoride doses on the human body.

Adolescent↗
PubMed1982

Skeletal development and dental fluorosis in 12--14-year-old Danish girls from a fluoride and a non-fluoride community.

The present study has examined the relationship between waterborne fluoride, dental fluorosis and skeletal maturity in two Danish areas containing less than 0.2 and 2.4 parts/10(6) F- in the drinking water. 12--14-year-old girls, 113 from the non-F- area and 122 from the F- area, born and raised in the areas, were examined. No relationship could be found between skeletal maturity and fluoride content of the drinking water. The association between the severity of dental fluorosis and skeletal maturity in the girls from the F- area was not statistically significant, but the tendency followed the same pattern as observed in tropical high and low fluoride areas.

Adolescent↗
PubMedDate not supplied

Skeletal maturity in 6-16-year-old Danish children assessed by the Tanner-Whitehouse-2 method.

A study of skeletal maturity was conducted in 1100 healthy Danish children at ages 6-16 years. The children were selected in a random manner reflecting a cross-section of socio-economic levels in Denmark. Skeletal maturity was assessed according to the method of Tanner and co-workers (TW-2, 1975). The results confirmed that the TW-2 method is well suited for the evaluation of skeletal maturity in Danish children. The RUS-score, however, was about six months advanced in Danish boys aged 14-15 and girls aged 12-15. A similar pattern has been reported for other groups of Danish children by Helm (1979). The present results revealed no relationship between skeletal maturity and socio-economic class.

Adolescent↗
PubMedDate not supplied

Skeletal maturity in Austrian children assessed by the GP and the TW-2 methods.

Skeletal maturity was assessed in 637 Austrian children from 7 to 16 years of age. The Greulich - Pyle and the Tanner- Whitehouse -2 ( RUS and TW 20-bone) methods were used. The GP ages showed some major deviations at and after puberty, especially in boys. The RUS and 20-bone ages conformed more closely to the standards although a general advancement in RUS ages was seen in girls after the age of 10 1/2. A similar pattern in RUS ages has been reported for other populations and may indicate a secular trend.

Adolescent↗
PubMedDate not supplied

Dental and skeletal maturity in adoptive children: assessments at arrival and after one year in the admitting country.

Seventy-one adoptive children from Asian countries, mainly Korea, were adopted by Danish parents. Height and weight were measured and dental and skeletal maturity assessed immediately after arrival and one year later. Increase in dental age was in complete concordance with the time interval between the two examinations. With regard to skeletal age, the majority of children showed an increased maturation rate although some of the youngest children seemed to be further retarded in maturation rate during their first year in Denmark. Comparison between two methods for assessing skeletal maturity revealed that the 'catch up' observed for children above one year of age was significantly more pronounced when assessed by the TW-2 method than when applying the G-P method. For the Korean children height and weight measurements increased more than the average values for the Danish population.

Adoption↗
PubMedDate not supplied

A two-film versus a four-film bite-wing examination for caries diagnosis in adults.

The aim of this study was to compare the caries diagnostic outcome of a two-film and a four-film routine bite-wing examination undertaken in an adult population. A digital bite-wing examination using two and four films, respectively, was performed in 174 patients. The radiographs from the two examinations were assessed jointly by 2 observers for the number of imaged surfaces in the area from the distal surface of the canine to the distal surface of the third molar and for the detection of carious lesions. Significantly more surfaces were available for examination by the four-film than by the two-film examination. Overlapping surfaces were recorded in 14 and 10%, respectively, of the surfaces imaged by the two-film and four-film set. The prevalence of primary enamel and dentinal caries was 6.8% with the two-film and 5.6% with the four-film method. In 1, 684 surfaces only imaged by the four-film method caries was detected in 20 surfaces. If these extra lesions were added to the number of lesions found by the two-film method the total disease prevalence using the last-mentioned method would increase by 2 per thousand. The majority (92-99%) of all recorded lesions were detected in surfaces located between the occlusal surface of the first premolar and the mesial surface of the third molar. The little additional diagnostic outcome obtained by the use of four instead of two films did not seem to match the extra resources (double patient charge and radiation dose, and extended scan/developing and recording time for the dentist) connected to the four-film method. Thus, it may be recommended that a routine bite-wing examination undertaken in young adults should be performed with only two films: one in each side of the mouth, placed behind the premolars and the first and second molars.

Adult↗
PubMedDate not supplied

Immunobiochemical characterization of the NMDA-receptor subunit NR1 in the developing and adult rat brain.

To investigate the developmental and regional expression of the NR1-subunit of the NMDA-receptor on the protein level, two polyclonal antisera [NR1(N) and NR1(C)] were raised against fusion proteins derived from the N- and C-terminal domain of the NR1-subunit, respectively. In Western blots of rat brain membranes, both antisera specifically recognized a single protein band with an apparent molecular size of 115 kDa. The regional distribution of the NR1-subunit immunoreactivity was analyzed in the developing and adult rat brain using sections blotted onto nitrocellulose membranes for immunostaining. With the NR1(N)-antiserum, strongest signals were detected in hippocampus, followed by cortex, striatum and thalamus, and weaker staining was observed in tectum, brainstem and cerebellum of adult brain. The NR1(C)-immunoreactivity exhibited a similar distribution, except that the staining in thalamus, tectum, brainstem and cerebellum was faint or virtually absent. The distinct pattern of NR1(N)- and NR1(C)-immunoreactivity arose during postnatal development. At birth, moderate staining with both NR1-subunit antisera was observed throughout the brain increasing strongly in most brain regions until postnatal day 21. In some brain areas, however, the NR1(C)-, in contrast to the NR1(N)-staining, decreased postnatally e.g. in thalamus, tectum and brainstem. The restricted staining intensity of the NR1(C)-antiserum in particular areas of adult and developing brain appears to reflect the emergence of C-terminal splice variants of the NR1-subunit which are not recognized by the NR1(C)-antiserum.

Animals↗