Biomedical subjects

A Wernet

Publications and source records attributed to A Wernet.

5 recordsLinked to original sources

PubMed2001

[Septic shock].

Septic shock is the most severe systemic inflammatory response to infection. Despite recent progress in prevention and critical care therapy, this syndrome is the most common cause of death in intensive care units. Major advances have been realized recently in the understanding of septic shock. Cellular receptors involved in bacterial recognition have been identified as Toll-like receptors. After bacterial challenge, these receptors become activated and initiate in septic shock patients a biphasic immunological response associated with coagulation disorders. Genetic variability among humans and their predisposition towards pathologic inflammatory responses have also been demonstrated. These current views on the pathophysiological aspects of septic shock open new therapeutic perspectives which should change the prognosis of this syndrome.

Bacterial Infections↗

PubMed2001

Amplitude measurements of Faraday waves.

A light reflection technique is used to measure quantitatively the surface elevation of Faraday waves. The performed measurements cover a wide parameter range of driving frequencies and sample viscosities. In the capillary wave regime the bifurcation diagrams exhibit a frequency independent scaling proportional to the wavelength. We also provide numerical simulations of the full Navier-Stokes equations, which are in quantitative agreement up to supercritical drive amplitudes of epsilon approximately equal 20%. The validity of an existing perturbation analysis is found to be limited to epsilon<2.5%.

Journal Article↗

PubMed1998

[Dynamic left intraventricular obstruction after reconstructive mitral valve surgery].

A 71-years-old patient, undergoing mitral valve repair for degenerative valvulopathy and correction of pectus excavatus experienced a cardiogenic shock after weaning from cardiopulmonary bypass. The shock occurred after calcium chloride administration and was unresponsive to inotropic drugs. Transoesophageal echocardiography showed left ventricular outflow tract obstruction due to systolic anterior motion (SAM) of the mitral valve. Discontinuation of inotropic drugs and volume expansion restored the haemodynamic status. By its haemodynamic effects calcium chloride can cause left ventricular outflow tract obstruction, recognized by transoesophageal echocardiography.

Aged↗

PubMed1998

Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes.

Hepatocyte transplantation might represent a potential therapeutic alternative to liver transplantation in the future; however, transplanted cells have a limited capacity to repopulate the liver, as they do not proliferate under normal conditions. Recently, studies in urokinase (uPA) transgenic mice and in fumarylacetoacetate hydrolase (FAH)-deficient mice have shown that the liver can be repopulated by genetically engineered hepatocytes harboring a selective advantage over resident hepatocytes. We have reported that transgenic mice expressing human Bcl-2 in their hepatocytes are protected from Fas/CD95-mediated liver apoptosis. We now show that Bcl-2 transplanted hepatocytes selectively repopulate the liver of mice treated with nonlethal doses of the anti-Fas antibody Jo2. FK 506 immunosuppressed mice were transplanted by splenic injection with Bcl-2 hepatocytes. The livers of female recipients were repopulated by male Bcl-2 transgenic hepatocytes, as much as 16%, after 8 to 12 administrations of Jo2. This only occurred after anti-Fas treatment, confirming that resistance to Fas-induced apoptosis constituted the selective advantage of these transplanted hepatocytes. Thus, we have demonstrated a method for increasing genetic reconstitution of the liver through selective repopulation with modified transgenic hepatocytes, which will allow optimization of cell and gene therapy in the liver.

Animals↗

PubMed1984

[Not Available].

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Demography↗