Electroconvulsive therapy for children.
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Biomedical subjects
Publications and source records attributed to A Wheaton.
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This article reports a case of major depression with catatonic symptoms which occurred in an 8 1/2-year-old girl. While taking oral antidepressants, her symptoms worsened markedly, and significant physical morbidity appeared imminent. Electroconvulsive therapy was successful in treating the patient's catatonic and mood symptoms, with no observable deleterious effects. Review of the English-language literature reveals no younger patients ever reported to have presented with such severe catatonia or to have been treated with electroconvulsive therapy.
Treatment of gerbils with 40 mg/kg of pentobarbital (i.p.) reduced the metabolic rate in the hippocampus and cerebral cortex by approximately 60%. However, the depression of metabolic rate was lost within 40 s of ischemia and further, pentobarbital delayed but did not prevent the depletion of energy metabolites observed in the ischemic brain.