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A Wirz

Publications and source records attributed to A Wirz.

27 records · Page 2Linked to original sources

[Adjustment to illness in patients with chronic physical diseases--initial experiences with the zurich illness adaptation questionnaire].

270 patients who suffered from gynaecological cancer, epilepsy or diabetes mellitus were examined with a newly developed questionnaire as to their coping behaviour. In order to assess the dimensions and reliability of the instrument, the data were evaluated by different statistical methods. For the three coping patterns established by factor analysis: anxiety/withdrawal, emotional neutrality/diversion and hope/facing of illness, significant correlations resulted with the variables age and sex. The outcome of the investigation suggests that if the disease takes a favourable turn, the chronically ill patient, similarly, copes with it in a favourable manner. For the differentiation and prominence of coping patterns, the patient's subjectively experienced impairment of his physical state of health seems to play an important role.

Adaptation, Psychological↗

Molecular cloning of the gene encoding an acidic ribosomal protein of the P2 family from the ciliate Euplotes raikovi.

We have characterized a macronuclear gene of the ciliate protozoan Euplotes raikovi, which encodes an acidic ribosomal protein of the P protein family. This gene shows the typical organization of the hypotrich ciliate macronuclear "gene-sized" molecules with Euplotes telomeres at the ends. The longest open reading frame encodes a conceptual protein of 113 amino acid residues, with a molecular mass and pI value of 11.45 kDa and 3.97, respectively. By using sequence homology analysis, the protein was found to belong to the ribosomal P2 protein family and was named Er P2, where Er stands for Euplotes raikovi. These proteins, generally called A (acidic/alanine rich) proteins in prokaryotes and P (phosphorylated) proteins in eukaryotes, in which they are divided into P1 and P2 families, play a role in the elongation step of protein synthesis. Approximately 40% amino acid sequence identity was found between the cloned protein and other known protozoan ribosomal P2 proteins. Within its N-terminal half, this protein contains several potential kinase phosphorylation sites. Protein Er P2 differs markedly from the consensus P protein sequence in its C-terminal region, usually highly conserved among eukaryotic ribosomal P proteins, and shows similarities with the C-terminus of the archaebacterial ribosomal A proteins. To our knowledge, this E. raikovi protein represents the first demonstration of a ribosome-associated protein of the P2 family in a ciliate protozoan.

Amino Acid Sequence↗