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Biomedical subjects

A Witczak

Publications and source records attributed to A Witczak.

16 recordsLinked to original sources
PubMed2002

Canned cod liver as a source of n-3 polyunsaturated fatty acids, with a reference to contamination.

Lipid composition (HPLC), fatty acid composition (GC/MS), lipid oxidation (peroxide value, anisidine value), UV-VIS and fluorescence spectra (Ex 365 nm), and susceptibility of lipids to oxidation (photooxidation test) as well as heavy metal, PCB, and DDT contents were determined in canned, raw, and thermally treated cod liver (separately in the released oil and in the solids). Canned products of three manufacturers were examined. Mean contents of n-3 polyunsaturated fatty acids (n-3 PUFAs) in the oil and solids were 31.91 +/- 1.83 and 16.59 +/- 7.48 g/100 g, respectively, the respective contents of docosahexaenoic acid (DHA) being 17.88 +/- 1.69 and 8.79 +/- 3.67 g/100 g. Lipid resistance to oxidation was found to decrease after thermal treatment of livers. However, the lipid oxidation level in canned liver stored for 3-8 months was not high and averaged, for the entire can content, 0.47 +/- 0.4 Meq O, the oil being more susceptible to oxidation that the solids. It is concluded that canned cod liver is a very good source of n-3 PUFA, particularly with respect to DHA. Heavy metal, DDT, and PCB contamination and the presence of lipid oxidation products in the canned products tested remain at a level producing no perceivable health hazard and could in no way interfere with consumption of recommended amounts of n-3 PUFAs.

Animals↗
PubMed2000

[Effect of dihydrotestosterone treatment on exercise induced ischemia in men with stable ischemic heart disease].

Many studies report the negative correlation between the endogenous testosterone (T) level and majority of risk factors for arteriosclerosis, as well as the presence and the extent of coronary artery disease (CAD) in men. Dihydrotestosterone (DHT) as a non-aromatizable androgen produces more favourable changes in the hormone profile than T. A constant level of androgens, independent on liver function, may be achieved by their transdermal administration. The aim of our study was to determine in a double-blind placebo study whether a 12-week treatment with transdermal DHT can decrease exercise-induced ischaemia in males with CAD. All patients underwent symptom-limited treadmill stress testing at the beginning of the study and after DHT treatment. The selected preliminary results are presented in this paper. Until now the study group has comprised ten men with stable CAD and decreased morning total T concentration. No side effects of treatment were noted during the study. Chronic DHT administration increased significantly: total exercise time, time to the onset of angina and time to 1 mm ST depression. Our results are consistent with the previous publications investigating T effects. The changes of heart rate and systolic blood pressure indicate rather direct coronary-relaxing effect of DHT than peripheral one.

Administration, Cutaneous↗
PubMed1999

Enalapril (10 mg/day) in systemic sclerosis. One year, double blind, randomised study (ESS-1): echocardiographic substudy--three months follow-up.

The ESS-1 study was designed to evaluate the long-term effects of the angiotensin converting enzyme inhibitor (ACEI) enalapril (10 mg per day) on the cardio-pulmonary system in patients with scleroderma (SSc). We estimated changes in heart diameters, systolic and diastolic left ventricle function and mean values of pulmonary artery pressure after 3 months treatment. The study group comprise 41 patients with SSc. 18 patients received placebo and 23 ones were given enalapril. After 3 months of treatment we did not observe statistically significant differences in heart diameters and left ventricle systolic function parameters between treated group and placebo. Enalapril therapy did not affect left ventricle diastolic function, nevertheless differences in MVA were almost of statistical significance. Echocardiographic signs of pulmonary hypertension were found in 4 patients.

Adult↗
PubMed1999

Enalapril (10 mg/day) in systemic sclerosis. One year, double blind, randomised study (ESS-1): ECG exercise testing--three months follow-up.

The ESS-1 study was designed to evaluate the long-term effects of the angiotensin-converting enzyme inhibitor (ACEI) enalapril (10 mg per day) on cardiopulmonary system of patients with systemic sclerosis (SSc). Exercise testing is used not only for estimation of coronary reserve but also physical capacity--the major determinant of quality of life. In each patient included to the ESS-1 study we performed ECG exercise test on treadmill (5 times at intervals of 3 months). The first follow-up was completed by 41 patients (23 patients in enalapril group and 18 in placebo group). The exercise duration in the placebo group was 683 +/- 295 sec and in enalapril group 768 +/- 173 sec. After 3 months of study there were no significant differences in both groups (758 +/- 271 sec and 720 +/- 191 sec respectively). The analysis of ST segment deviation did not provide any significant changes after 3 months of treatment. We conclude that 3 months enalapril treatment did not improve exercise tolerance in patients with systemic sclerosis.

Adult↗
PubMed1993

[Mechanical infertility in the female population of the Kielce province. III. Evaluation of sexual steroid levels during the menstrual cycle].

The results of the sexual steroids RIA examinations during the menstrual cycle at women with mechanical sterility in confrontation with the group of fertile women were shown. Mean concentrations of progesterone and estradiol in serum were statistically significant in sterile women. In the group of women with mechanical sterility there was no estrogen peak and levels of estradiol in ovulation period were significantly lower in confrontation with the control group.

Estradiol↗
PubMed1993

[Mechanical infertility in the female population of the Kielce province. IV. Evaluation of hypophyseal gonadotropin levels during the [Mechanical infertility in the female population of the Kielce province. IV. Evaluation of hypophyseal gonadotropin levels during the menstrual cycle].

The paper describes results of the RIA of the hypophyseal gonadotropins estimated in the menstrual cycle in the group of women with mechanical sterility in confrontation with the group of fertile women. Significantly higher mean concentration of FSH in follicular and luteal phase and higher concentration of LH after ovulation in the group of sterile women were found. There was no LH peak and mean concentration in 14th day of menstrual cycle was significantly lower in the group of women with mechanical sterility. Mean PRL concentration was higher but within the bounds of standard in sterile women.

Adult↗
PubMed1993

[Vulvovaginitis in girls. III. Clinical manifestations and efficiency of therapy].

The paper describes a frequency of clinical manifestations of vulvovaginitis at the group of 277 girls. Duration of therapy and frequency of reinfections were analysed. It was proved, that reinfections occurred four time frequently in mixed infections (caused jointly by specific and non-specific factor) and three time frequently in cases caused by many different species of bacteria. Reinfections were found at 25% of the girls, nine time frequently at only local treated cases. Mixed character of infection and variety of cultured bacteria significantly prolonged the duration of therapy.

Adolescent↗
PubMed1989

[Perinatal hysterectomy].

Cases of hysterectomy in women in labour in the years 1977-1986 were analysed retrospectively. In the total number of 16390 labours in 23 cases hysterectomy was done in the period around the labour, that is 0. 14%, which was done by caesarean section in 13 cases (0.95%). Multiparae accounted for 73.9% of cases. In 21.7% of cases labour occurred before the 36th week of pregnancy. In 70% of cases injury to the uterus was noted in women giving birth by natural ways and natural forces after earlier operations leaving scars or with endometriosis. In women after caesarean section in 70% of cases the cause of hysterectomy was infection and septic shock, and in 15.4% uterine atonia was present. Complications were related most frequently to the urinary system--ureteral and vesicovaginal fistulae (36.4%) and coverings--wound infection (45.5%). The mean time of stay of the patients in hospital was 22 days. There were no deaths.

Adolescent↗