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Biomedical subjects

A Woolf

Publications and source records attributed to A Woolf.

At least 91 records · Page 5Linked to original sources

A clinical study of Laotian refugees infected with Clonorchis sinensis or Opisthorchis viverrini.

Twenty-six Laotian refugees infected with Clonorchis or Opisthorchis liver flukes, and 15 uninfected controls, were assessed clinically by history, physical examination, serum 5'nucleotidase level, and serum immunoglobulin E level. Ultrasound studies of the biliary tract were also done on a subset of six infected subjects. The results showed no differences between subjects and controls with respect to clinical symptoms, physical findings, 5'nucleotidase, or biliary ultrasound. Mean serum IgE levels were four times higher in fluke-infected individuals than uninfected controls (P less than 0.002). Even when those infected with other parasites in addition to Clonorchis were excluded from the analysis, serum IgE levels remained three times higher in fluke infected individuals (P = 0.06). This study provides some evidence that the fluke provokes a mild immune response in the asymptomatic human host but may not require eradication.

Clonorchiasis↗

Ticks on white-tailed deer fawns from southern Illinois.

Seventy-six white-tailed deer (Odocoileus virginianus (Zimmermann] fawns captured on Crab Orchard National Wildlife Refuge in southern Illinois during June-July 1980-1983 were aged and examined for ticks. The prevalence of ticks (Amblyomma americanum (Linnaeus, 1758) and Dermacentor variabilis (Say, 1821] was 80%; intensity of infestation ranged from one to 123 ticks per fawn, averaging 21.6. Tick intensity correlated poorly with age suggesting that there were other, more important determinants of infestation rates. Packed cell volumes in blood of the fawns increased significantly with age, but were not significantly affected by existing tick intensities. Ticks were not directly or indirectly implicated in any of 16 mortalities that occurred among 61 radio-collared fawns monitored for approximately 6 mo post-partum, and were not considered a serious health problem for fawns on the study area.

Animals↗

Serologic evidence of Anaplasma marginale infection in Illinois white-tailed deer.

A total of 175 deer and 54 cattle from Crab Orchard National Wildlife Refuge in southern Illinois were tested for antibody to Anaplasma marginale, using the capillary tube agglutination test. A total of 12 (6.9%) deer and 7 (13%) cattle were serologically positive. Serologic prevalence in deer increased from 0 at 6 months of age to 14% at 2 1/2 or more years of age. Cattle less than approximately 1 year of age were not seropositive.

Anaplasmosis↗

A summary of the prevalence of Parelaphostrongylus tenuis in a captive wapiti population.

A total of 87 brains from harvested and collected wapiti and red deer (Cervus spp.) were examined grossly and microscopically between 1973 and 1977 in a 2104 ha. preserve. Prevalence of infection significantly increased from 26.6% of the sample in 1973 to 64.3% in 1975 (P less than .05). A decline to 47.7% in 1977 (P greater than .05) was not significant. However, the number of clinical cases was significantly higher in 1976-1977 (P less than .02) than previously reported in 1973-1975.

Animals↗

Nephritis in children and young adults with systemic lupus erythematosus and normal urinary sediment.

One male and seven female patients (aged 6 to 26 years) with systemic lupus erythematosus (SLE), normal urinalyses, and normal biochemical tests of renal function, had renal biopsies to determine if significant nephropathy existed. Several had active SLE in other body systems at the time, either clinically or as evidenced by low serum complement and high native DNA antibody levels. The renal biopsy specimens were studied by light, fluorescent antibody, and electron microscopy. Three patients had a generalized segmental, two had a focal segmental, and one had a generalized diffuse proliferative glomerulonephritis. In addition, one patient had minimal glomerular findings with interstitial inflammation. All eight patients were found to have moderate immune complex deposition by immunofluorescence and/or electron microscopy studies. The absence of clinical renal involvement in patients with SLE does not preclude ongoing active and "silent" glomerular damage with moderately severe proliferative changes.

Adolescent↗

The development of clinical signs and the population significance of neurologic disease in a captive wapiti herd.

Clinical signs attributable to meningeal worm (Parelaphostrongylus tenuis) were recorded in three male and three female wapiti (Cervus elaphus canadensis) ranging in age from 5 - 29 months. The study was conducted from September, 1976 to May, 1977 in a 2104-ha preserve. Some differences were noted in occurrence, time schedule and sequence of signs but the basic pattern was similar. The mean time between initial sign observed and death was 100 days. The effect of neurologic disease on population socialization, harvest and recruitment is discussed. A comparison of projected potential population numbers with sighting data in 1959-1977 revealed a trend of lower than expected numbers since 1968 related to suspected neo-natal mortality as well as known natural mortality in the younger age classes due to meningeal worm infection.

Animals↗

Prevalence and effects of Parelaphostrongylus tenuis in a captive wapiti population.

Prevalence of neurologic disease attributed to Parelaphostrongylus tenuis was investigated in a population of wapii (Cervus elaphus canadensis) enclosed in a 2080 ha. preserve. Brains of 44 animals harvested in 1973, 1974 and 1975 were examined grossly and microscopically. Prevalence of infection increased each year from 26.6% of the sample in 1973 to 64.3% in 1975. These data suggest that wapiti living close to white-tailed deer (Odocoileus virginianus) may have a high prevalence of infection, but many individuals may not show signs. Accordingly, routine histologic examination of natural mortality cases without supporting observations of clinical signs would be inadequate to define cause of death. While the effects of the parasite in the population studied did not produce a high herd mortality or a sudden die-off situation, the apparent greater susceptibility of the younger age-classes to the parasite would have a detrimental effect on population recruitment and might limit the growth of wapiti herds living in proximity to white-tailed deer that harbor P. tenuis.

Animals↗

Occurrence of rumenitis in a supplementary fed white-tailed deer herd.

Rumenitis was observed with increased frequency in a herd of white-tailed deer (Odocoileus virginianus) maintained on a high carbohydrate supplemental ration. Healing rumen scars were found in 4.4% (n=225) of animals examined in 1973; 24.1% (n=278) in 1974; and 42.5% (n=308) in 1975. The lesions often involved nearly the entire ventral blind sac of the rumen. Histopathologic studies did not define the etiologic agent and invasion by either fungi or Fusiformis necrophorus was not a prominent feature in the cases examined. Recovery appeared to be complete and the disease was not considered to be an important herd mortality factor.

Animal Feed↗

Prevalence of renal urolithiasis in a large, captive white-tailed deer herd.

Prevalence of renal urolithiasis in a large, captive white-tailed deer (Odocoileus virginianus) herd was examined over a two-year period of time. In 1973, 1.3% of 225 deer examined had calculi in the renal pelvis and 4.4% had kidney lesions, either independent or in combination with the calculi. In 1974, prevalence increased and 5.9% of 354 deer had calculi and 6.5% had kidney lesions. Calculi and lesions affected all sex and age-classes. Involvement was both unilateral and bilateral with 23.8% having stones in both kidneys and 30.4% having lesions in both kidneys. Lesions and calculi occurred together in 42.8% of cases. Etiology is unknown, but possible relationships are discussed.

Animals↗