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Biomedical subjects

A Woscoff

Publications and source records attributed to A Woscoff.

At least 19 recordsLinked to original sources

Nevoid keratosis of the nipple.

A patient with nevoid keratosis of the nipple is described. The clinical features, histology, therapy, and prognosis are discussed.

Adult

[PCR determination of an association between class II HLA and pemphigus vulgaris].

Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the skin and mucous membranes. It is characterized by the presence of an autoantibody directed against desmoglein 3, which causes acantholysis and blister formation. In this study, we examined the HLA antigens of 30 caucasian argentinian patients compared with 199 controls. We used the PCR-SSO method (Polymerase Chain Reaction-Sequence Specific Oligonucleotide). We found that PV patients had significantly increased frequencies of HLA DR4 (RR = 3.80, P = 0.001) and HLA DR 14 (RR = 5.97, P = 0.0001). As in other populations, two associated alleles were found: the first was DR beta 1*0402 (RR = 44.70, P = 10.7) and DQ beta 1*0302 (RR = 71.82, P = 10(-7)) and the second was DR beta 1*1401 (RR = 117.94, P = 10(-7)) y DQ beta 1*0503 (RR = 86.95, P = 10(-7)).

Alleles

[Contact dermatitis caused by heterologous proteins].

A patient (gastronomic employee) presented a sharp dermatosis of eczema type in both hands. Patch-test confirmed sensitivity to heterologous proteins contained in the squid, which he was accustomed to handling. Although the levels of the IgE were elevated, the final diagnostic was dermatitis by allergic heterologous proteins.

Adult

[Ulcerative plantar lichen. Is it an indicator of an autoimmune disease?].

A 48 years old female has had erosive and ulcerative lichen planus with sores in both heals, onychodystrophy and typical lesions in oral mucous membranes. Laboratory examination revealed specific abnormalities indicative of autoimmune thyroiditis and primary biliary cirrhosis. This clinical variant of lichen planus was associated with immunological disturbances. Autoimmune diseases must be investigated in patients with erosive and ulcerative lichen planus.

Autoimmune Diseases

[Keratoderma with epidermolytic hyperkeratosis].

Three members of one family with keratoderma Thost-Unna and histopathological picture of epidermolytic hyperkeratosis are reported. Several dermatoses with this abnormality of the keratinization are mentioned and the literature cases with keratoderma are reviewed. The treatment with oral aromatic retinoid though improved the hyperkeratosis, had to be discontinued because the vulnerability of the newly skin. Exhibited erosions with the consequent discomfort. The association of keratoderma with epidermolytic hyperkeratosis would be more frequently observed if the histopathological examination were performed in all cases.

Adolescent

Chondroid syringoma.

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Adenoma, Sweat Gland