Characterization of the cold-sensitive murine hepatitis virus mutants rescued from latently infected cells by cell fusion.
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Animals↗
Biomedical subjects
A Y Sakaguchi
Publications and source records attributed to A Y Sakaguchi.
Rescue of a positive stranded RNA virus from antigen negative neuroblastoma cells.
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Animals↗
Migration inhibition factor study in Histoplasma capsulatum.
Mice sublethally infected with viable Histoplasma capsulatum or immunized with merthiolate-killed yeast phase cells showed decreased mortality on subsequent challenge infection as compared to controls. Migration inhibition (MI) assays using peritoneal and spleen cells from immunized but unchallenged mice showed no parallel correlation with percent mortality. MI assay indices fluctuated without concomitant changes in resistance to challenge injection with live yeast phase cells. Viable vaccines induced greater resistance to challenge infection than killed cells, although both were comparable in sensitizing ability as measured by MI assay techniques with this mouse model.
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Interferon production and activity in mouse neuroblastoma cells.
Mouse neuroblastoma cells are capable of synthesizing interferon after induction with virus or polynucleotides. Differentiation of neuroblastoma cells depresses interferon synthesis without an apparent effect on sensitivity to interferon.
Animals↗