Biomedical subjects

A Yüce

Publications and source records attributed to A Yüce.

78 records · Page 5Linked to original sources

PubMedDate not supplied

Acute hemolysis in association with hepatitis B infection in a child with beta-thalassemia trait.

Autoimmune hemolytic anemia may occur in the course of some viral diseases such as Coxsackie virus, cytomegalovirus, Epstein Barr virus, Influenza A, herpes simplex virus, and rarely hepatitis B virus infection. The role of being heterozygous for beta-thalassemia in hemolysis during acute viral hepatitis is not known. In this report, we present an eight-year-old boy with jaundice and anemia. The diagnosis of hepatitis B virus infection and hemolytic anemia were made on the basis of physical and laboratory findings. A hemoglobin electrophoresis revealed that the child was heterozygous for beta-thalassemia. No specific etiology could be found for hemolytic anemia. It remained unclear whether hemolytic anemia in this patient was merely a coincidental finding or whether hepatitis B virus infection and beta-thalassemia trait had played a role in causing hemolysis.

Acute Disease↗

PubMedDate not supplied

Lipidosis with sea-blue histiocytes. Report of two siblings with lung involvement.

Two siblings, an eight-year-old girl and a three-year-old boy with lipid storage disease, most likely non-neuropathic Niemann-Pick disease (NPD) with sea-blue histiocytes, are presented. Both of them had foamy and sea-blue histiocytes in their bone marrow smears and reticulo-nodular appearance of both lungs on their chest X-rays. Case 1 had diffuse, biopsy-proven, pulmonary involvement associated with sea-blue histiocytes. Although diffuse reticulo-nodular pulmonary infiltration of non-neuropathic NPD (type B) is frequently detected on chest X-rays, to our knowledge there is only one reported adult case of lipidosis resembling NPD in which severe pulmonary involvement associated with pigmented histiocytes and Niemann-Pick cells were demonstrated at autopsy.

Bone Marrow↗

PubMedDate not supplied

Type I glycogenosis with renal tubular dysfunction (presentation of two cases).

Two patients with hepatic glycogenosis associated with Fanconi syndrome are presented. Both patients were treated with a neutral phosphorus solution, an oral alkaline solution, cholecalciferol and uncooked cornstarch. The proximal renal tubular functions were corrected in the patient who used cornstarch properly, which may indicate a causal relationship between Fanconi syndrome and glycogenosis.

Administration, Oral↗

PubMedDate not supplied

Unusual appearance of the liver on ultrasonography and computed tomography in a patient with cystic fibrosis.

A seven-year-old boy with cystic fibrosis (CS) who presented with abdominal pain is reported. Ultrasonographic and computed tomographic studies of the upper abdomen revealed unusual liver findings. An ultrasound scan showed a liver that was exceedingly heterogeneous and a mixed echo pattern with dominant hyperechogenicity. Computed tomography showed large, multiple hypodense cyst-like lesions in the liver. Using the ultrasound scan as a guide, a needle biopsy was performed. The pathological findings were in accord with the findings obtained from ultrasonography and computed tomography, and were consistent with pathological findings seen in CS cases.

Biopsy, Needle↗

PubMedDate not supplied

Helicobacter pylori serology in childhood.

Serology is now generally accepted as a valid noninvasive screening method for the detection of Helicobacter pylori (Hp) infection. We determined the frequency of serum Hp IgG antibodies in 59 children with dyspeptic complaints and 48 age-matched controls by ELISA. Positive Hp antibodies were found in 52.5 percent of patients and 41.7 percent of controls. The difference was not statistically significant. The percentage of positivity increased with age for both patients (50% in 5-9, 51.7% in 10-14 and 72.7% in 15-17 year age-groups) and controls (36.8% in 5-9, 50% in 10-14, 68.4% in 15-17 year age-groups). These results suggest that Hp infection has a relatively high prevalance among children in our region, and increase with age. A large proportion of asymptomatic children also demonstrate signs of past or present exposure.

Adolescent↗

PubMedDate not supplied

Long-term follow-up of hepatitis B virus carriers with normal transaminases levels.

There has been very little data recorded on the natural course of chronic hepatitis B virus infection in asymptomatic children. In order to assess the natural course of liver disease in hepatitis B surface antigen (HBsAg) carriers with normal liver tests, 124 such children (81 males, 65.3%) were followed for six to 144 months (mean 36.8 +/- 22.8 months). Liver tests and hepatitis B virus (HBV) markers were tested at least every six months. In the beginning, hepatitis B e antigen (HBeAg) was positive in 61 (53%) of the 115 carriers of HBsAg who were tested. Anti-HBe was positive in 51 (44.3%), and both HBeAg antigen and anti-HBe were negative in three (2.7%) carriers. The prevalence of HBeAg was not affected by the patient's age or sex. During follow-up, 11 patients (18%) lost HBeAg (a mean annual clearance rate of 5.8%), and 12 patients (9.7%) lost HBsAg (a mean annual clearance rate of 3.1%). We found no difference in the clearance of HBsAg and HBeAg by age and sex. The presence of another HBsAg positive person in the family affected HBsAg clearance rate but not HBeAg clearance. Only seven patients (5 HBeAg positive and 2 anti-HBe positive) developed transient elevations in liver transaminases. Three of five HBeAg positive children cleared HBeAg after transaminases elevations. Of the five patients who underwent percutaneous liver biopsies, non-specific changes were found. It is concluded that hepatitis B carriers with normal liver tests should be followed with liver function tests alone and that long-term prognosis is good.

Carrier State↗