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Biomedical subjects

A Yannopoulos

Publications and source records attributed to A Yannopoulos.

7 recordsLinked to original sources
PubMed2005

mRNA quantification and clinical evaluation of telomerase reverse transcriptase subunit (hTERT) in intracranial tumours of patients in the island of Crete.

Telomerase is a reverse transcriptase that maintains telomeres by adding telomeric TTAGGG repeats to the ends of human chromosomes. The aim of this study was to evaluate quantitatively the mRNA expression of telomerase catalytic subunit (hTERT) in different types of intracranial tumours in relation to their histologic pattern and grade and correlate it with progression-free (PFS) and overall survival (OS) of patients. Human telomerase reverse transcriptase mRNA levels were estimated by the use of real time RT-PCR in 68 samples of intracranial tumours. It revealed statistical correlation between hTERT mRNA expression levels and the grade of the tumours (P<0.001). Patients having negative expression of hTERT mRNA had statistically longer PFS (P=0.031) and OS (P=0.047). Cox univariate regression analysis revealed that hTERT mRNA-positive patients had a high and statistically significant risk of relapse (hazard ratio (HR) of 2.24 and P=0.038). In the Cox multivariate regression model, the levels of hTERT mRNA were adjusted for tumour grade and patients age, and since there was statistically significant relationship between the levels of hTERT mRNA and the grade of the tumours (P=0.003 or P=0.006, respectively), hTERT mRNA levels could not be considered as an independent prognostic factor for PFS or OS.

Brain Neoplasms↗
PubMed1993

Elasticity estimates from a dynamic model of interrelated demands for private and public acute health care.

This paper investigates the private/public mix in acute health care provision in the UK. It uses an interrelated shares model derived from a translog function combined with dynamic adjustment. Using prices for public care constructed from NHS waiting lists, the insurance cost of private care and the retain price index, impact, intermediate and long run elasticities of demand for private and public care are obtained. The role of hospital consultants and of an aging population are also considered.

Acute Disease↗
PubMed1989

Mono-vitamin B6 complexes of palladium(II) and their interactions with nucleosides.

The interactions of potassium tetrachloropalladate(II) with the B6 vitamins pyridoxal, pyridoxine, and pyridoxamine in 1:1 molar ratio have been studied. From DMF solutions, the ionic trichloro (pyridoxal or pyridoxine) palladates(II) were isolated. Pyridoxamine, on the other hand, in aqueous solutions gave the dimeric complex bis [mu-chloro-pyridoxaminato-palladium(II)]. In the first two complexes, the ligands coordinated to palladium through their pyridine nitrogen while, in the last one, pyridoxamine acted as a chelating ligand through its phenolic oxygen and aminomethyl nitrogen. All three complexes reacted with nucleosides, yielding the complexes [Pd(PL)(Nucl)Cl2], [Pd(PN)(Nucl)Cl2], and [Pd(PM-H+)(Nucl)Cl], respectively. Those complexes with one ionizable N(1)H imino proton underwent deprotonation, and the new mixed ligand complexes [Pd(PL)(Nucl-H+)Cl], [Pd(PN)(Nucl-H+)], and [Pd(PM-H+)(Nucl-H+)] were formed. In all mixed ligand complexes, the B6 vitamins maintained their coordination modes. The nucleosides, on the other hand, exhibited their usual coordination sites, i.e., in the nondeprotonated complexes, purine nucleosides coordinated only through their N7 atom. In the deprotonated complexes, they acted as bidentate ligands and coordinated through their N7 and O6 atoms. All complexes were characterized with elemental analyses, conductivity measurements, and various spectroscopic techniques.

Chemical Phenomena↗
PubMedDate not supplied

Diagnosis of pancreatic cancer.

Fifty-five patients underwent thorough laboratory and clinical investigations for pancreatic cancer. The disease was diagnosed in 32 patients. Thirty of these plus three others who did not undergo the sequence of tests underwent exploratory surgery. Pancreatic cancer was found in all. The high diagnostic accuracy was mainly due to the secretin test. We used Dreiling's technic for this test, which we think is the most popular and accurate technic.

Duodenum↗