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Biomedical subjects

A Zabalegui

Publications and source records attributed to A Zabalegui.

13 recordsLinked to original sources
PubMed2006

[Analysis of the Educational Program for Self-Care in the Elderly (PECA) for improving the quality of life of the elderly].

OBJECTIVE: To determine the efficacy over 12 months of the educational programme on self-care of the elderly (PECA), which covers quality of life, nutritional status, and perceived social support of people over 65 living in their own homes. DESIGN: Pre-test/post-test experimental study with control group. SETTING: Urban population in the Manso Health District (Example, Barcelona), Spain. PARTICIPANTS: Persons over 65 living in their own homes, healthy or with chronic illnesses characteristic of their age, who had a normal score in the Pfeiffer test. A total of 70 subjects (35 per group) were selected and 5 of the control group left the study. INTERVENTION: Programme on self-care of the elderly, including education on physical activity, nutrition, and social support. MEASUREMENTS: Dependent variables were quality of life, measured by the Nottingham Health Profile; nutritional status, measured by the Mini-Nutritional Assessment (MNA); and social support, measured by the Duke-Unk Functional Social Support Scale. RESULTS: The study sample had an average age of 70.9 (SD, 3.1); 88.2% had self-perception of good health; and 21% lived alone. We only found statistically significant differences between pre- and post-intervention observations in nutritional status (P=.001). CONCLUSION: Despite a statistically significant difference in the variable of nutritional status, the difference was not "clinically" relevant. The ineffectiveness of the intervention is due to our starting from a very homogeneous sample, which had good health status and well-established social networks.

Aged↗
PubMed2006

[Utility of vasopressin in cardiopulmonary resuscitation].

Many vasopressants have been studied in cardiopulmonary resuscitation (CPR) to increase cerebral and coronary perfusion. Although there is a debate on the utility of epinephrine, this is the one that has been used historically, above all after verifying that other agents such as norepinephrine, metoxamine or phenylephrine, have not been shown to be more effective. Currently, due to the good experimental results, the use of vasopressin (ADH) in CPR is being evaluated. However there is little (only three studies) and debated evidence based on randomized clinical trials (norepinephrine or ADH) in humans. Once these are reviewed, it can be concluded: The results of the three randomized studies in humans obtain different results regarding the utility of ADH in cardiorespiratory arrest (CRA) secondary to ventricular fibrillation, electro-mechanical dissociation or asystole. More prospective studies are needed to know the role of ADH in prolonged CRA and in asystole, that may be the subgroups that can benefit the most from this drug. The neurological repercussion of a drug in the context of CRA should be evaluated before its inclusion in the CPR guides.

Cardiopulmonary Resuscitation↗
PubMed2003

[Treatment of allergy to mushrooms].

The treatment of patients with respiratory allergy is based on environmental control measures, pharmacological and immunotherapy treatment. The third cause of allergic respiratory disease in our environment is mushrooms, the most frequently involved being the Alternaria class. However, due to the great difficulties in their diagnosis and specific treatment, there are few controlled studies on immunotherapy with mushroom extracts. A clinical test was carried out with a suitable, biologically standardized extract for the diagnosis and treatment of patients allergic to Alternaria. A second phase determined the maximum tolerated dosage of this extract administered through immunotherapy, in depot preparation and in conventional dosage, which was 0.1 mg/ml of Alt a I. This dosage was established as the maintenance dosage in the following phase (double blind test controlled with placebo), in which the efficacy and safety of the immunotherapy with this extract was determined, administered in immunotherapy to the mentioned maintenance dosage, to 28 patients with rhinitis and/or asthma due to allergy to Alternaria. All the patients reached the pre-established maintenance dosage of 1670 BSU. The treatment proved efficient, producing an improvement in the symptoms, respiratory function, subjective evaluation of patient and doctor, and severity of the disease. The immunological response supported the clinical efficacy, with an increase in the IgG and a fall in the IgE over the course of the study. Tolerance to the treatment was excellent, with only two light systemic reactions registered in the 711 dosages administered (0.28% reactions/dosages administered).

Adolescent↗
PubMed2003

[Inhalation techniques in the treatment of asthma].

In the pharmacological treatment of asthma, the most suitable way is by inhalation, since this enables us to achieve a greater concentration of medicine in the affected organ than systemic medication, and besides the latter's secondary effects are minimized. The suitable use of inhalers and hence their efficacy depends on very different factors. Some of those of a merely technical kind are as follows: A suitable volume of inhalation. The rhythm of inhalation. The length of the inspiratory apnea following administration of the medicine. The coordination between the inspiration of the aerosol and activation of the device, in the case of the metered dose inhaler (MDI). One of the reasons for the incorrect use of MDI aerosols is the lack of coordination between activation of the device and inspiration. This has led to the design of different devices that avoid the need for this coordination, such as: inhalation chambers and devices for inhaling dry dust. It has also been suggested in the literature that the causes of these mistakes are to be found in the health professionals not knowing, or not suitably teaching the patients how to handle the devices. In spite of being designed to facilitate correct administration, suitable knowledge of the technique of their use by the patient is required.

Administration, Inhalation↗
PubMed2001

Palliative nursing care in Spain.

This paper describes the practice of palliative nursing care in Spain. The management of palliative hospital and home care is presented. Nursing roles in the multidimentional aspects (physical, psychological, social, cultural and spiritual) of patient and family care are provided. Nursing participation in informing and counselling patients is evaluated, together with nursing cooperation in multidisciplinary work. Finally, this paper states the current lack of nursing education in palliative care and the recommendations for integrating palliative care into the nursing curriculum.

Education, Nursing↗
PubMed1999

Coping strategies and psychological distress in patients with advanced cancer.

PURPOSE/OBJECTIVES: To examine the relationship between coping mechanisms and psychological distress in patients with advanced cancer receiving chemotherapy. DESIGN: Descriptive, correlational study. SETTING: Private and public hospitals in New York, NY. SAMPLE: 132 patients, ages 33-83, with advanced breast, ovarian, lung, colorectal, or other cancers. METHODS: Mail survey using the Ways of Coping Inventory-Cancer Version and the Profile of Mood States. MAIN RESEARCH VARIABLES: Coping strategies, psychological distress. FINDINGS: The coping strategies distancing, cognitive escape-avoidance, and behavioral escape-avoidance were related to psychological distress. Distancing was negatively related (r = -0.25) and cognitive escape-avoidance (r = 0.38) and behavioral escape-avoidance (r = 0.38) were positively related to psychological distress (p < 0.01). Collectively, the coping strategies explained 36% of the variance of psychological distress. The most important coping mechanism contributing to overall psychological distress was behavioral escape-avoidance, followed by cognitive escape-avoidance. CONCLUSIONS: Low levels of psychological distress were associated with low levels of cognitive and behavioral escape-avoidance and high levels of distancing. IMPLICATIONS FOR NURSING PRACTICE: Nursing interventions that reduce cognitive and behavioral escape-avoidance and enhance distancing should be tested, through further research, in relation to their ability to decrease psychological distress in patients with advanced cancer.

Adaptation, Psychological↗
PubMed1998

Initial clinical evaluation of radiolabeled MX-DTPA humanized BrE-3 antibody in patients with advanced breast cancer.

To evaluate radiometal-labeled humanized BrE-3 (huBrE-3) monoclonal antibody as a radioimmunolocalization and therapeutic agent in breast cancer patients, tumor localization, pharmacokinetics, radiation dosimetry, and immunogenicity of (111)In-labeled combined 1-p-isothiocyanatobenzyl 3-methyl- and 1-p-isothiocyanatobenzyl 4-methyldiethylenetriamine pentaacetic acid (MX-DTPA) huBrE-3 were studied. Seven women with BrE-3 antigen-positive, metastatic breast carcinoma underwent (111)In huBrE-3 infusion (5 mCi; 50 mg), followed by serial gamma camera imaging and plasma sampling. Region of interest analysis of images was used to make radiation absorbed dose estimates for (111)In huBrE-3. Data were extrapolated to 90Y huBrE-3. Human anti-human antibody (HAHA) response was measured in serum samples obtained up to 3 months after infusion. Patients tolerated infusions well. Seventy-six percent of 105 known sites of disease were identified on planar and single-photon emission computed tomography scans. For six of seven patients, a biexponential model fit the plasma time-activity curve best with an average T1/2alpha=10.6+/-8.5 (SD) h and average T1/2beta=114.2+/-39.2 h. Radiation absorbed dose estimates for (111)In huBrE-3 for whole body averaged 0.53+/-.08 rads/mCi. Dose estimates for 90Y huBrE-3 for marrow averaged 8.4+/-11.9 rads/mCi, and for tumors, 70+/-31.5 rads/mCi. Liver radioactivity uptake averaged 19.7+/-8.8% injected dose at 24 h after infusion, translating into an average radiation absorbed dose 21.1+/-12 rads/90Y mCi administered. Only one of seven patients demonstrated a low level of HAHA response. Although the plasma half-lives are longer and marrow dose higher for radiolabeled huBrE-3 compared with the murine construct, the excellent tumor localization, good tumor dosimetry, and low immunogenicity support the use of 90Y-huBrE-3 antibody for radioimmunotherapy of breast cancer.

Adult↗
PubMed1995

[Hemoglobin in blood donor selection].

PURPOSE: To evaluate and establish a relationship between serum ferritin value and haemoglobin level, serum iron or transferrin in volunteer blood donors. MATERIAL AND METHODS: We have studied a group of 479 blood donors from Navarra's Health Area V, whose blood cell examination, iron, ferritin and transferrin values were determined. We classified these donors in 4 groups according to their ferritin concentration (ng/mL): f1 (0-12), f2 (13-20), f3 (21-400) and f4 (more than 400). The results were analyzed by the statistical program SPSS/PC+. The sensitivity, specificity, accuracy and predictive value of the positive test, for the determination of haemoglobin level as an indicator of iron deposits were calculated. RESULTS: The comparative statistical study of all these groups indicated that there were significant differences in the ferritin and the haemoglobin values (p < 0.001 and p < 0.05, respectively), except between f1 and f2, which only presented and intergroup difference in the ferritin values. In blood donors, the estimation of iron deposits from the hemoglobin level showed a diagnostic sensitivity greater than 90%. CONCLUSIONS: Haemoglobin values would allow the selection of those donors that could have an iron deficiency, or a borderline concentration; nevertheless, it would not allow the distinction between these two groups. This last observation is not important because donors that show a ferritin value lower than 20 ng/mL should not give blood. When the ferritin is greater than 20 ng/mL in men, the iron deposits will be adequate in 97% of them. This percentage is about 90 in women whose haemoglobin level is greater than 12.5 g/dL. Therefore, we consider that haemoglobin values present a good cost/benefit ratio for donor selection.

Adult↗
PubMed1994

Secondary cancer prevention in the elderly.

Cancer incidence rises as the population ages. Fifty percent of all cancer diagnoses and 60% of all cancer deaths in the United States occur in people older than 65 years of age. Because the elderly are underrepresented in cancer screening activities, the identification of factors that encourage or discourage them to engage in secondary cancer prevention activities is a health care priority. The purpose of this study was to investigate the relationship between health perception (measured by Ware's HPQ) and participation in cancer screening programs (measured by PCSQ) in 323 elderly New Yorkers from a variety of backgrounds. A statistically significant (p < 0.001) moderate positive correlation between both variables (r = 0.51) was found by using the Pearson's Product Moment Correlation. The researcher's hypothesis, that there is a relationship between both variables, was supported. The results indicate that in addition to health perception, demographic factors (measured by DDQ), including education, economic status, ethnic group, and gender, are predictors of participation in cancer screening.

Aged↗
PubMedDate not supplied

[Severe gastroesophageal lesions due to caustics: the role of nutritional support].

AIM: Describe the clinical-nutritional state of patients with severe digestive lesions after the ingestion of caustic substances, as well as their nutritional support (NS). PATIENTS AND METHODS: We studied 5 patients diagnosed by means of early endoscopy, treated with artificial nutrition, 4 of whom used enteral nutrition. During the acute phase of the disease, an evaluation of the nutritional state (ENS) was done, by means of the following parameters: body mass index (BMI), creatinine/height index (CHI), visceral proteins, nitrogen content of 24 h urine, and plasma zinc level. The corrected Harris-Benedict equation was used to calculate the energy needs. RESULTS: The BMI did not experience significant changes. The CHI decreased in a large degree. The long life visceral protein did not change notably, and those of intermediate and short life increased. The losses of nitrogen were increased. We found hypozincemia in 4 of the cases. The mean Kcal provided was 2323 +/- 105. CONCLUSIONS: In the described patients, given their catabolic condition, and early ENS and NS should be done. If at all possible, the NS shall be enteral, with or without parenteral support. In our study we have found a cessation of the weight loss, a decrease of somatic protein with a short term re-filling of the visceral protein pol. The zinc levels should be monitored.

Aged↗