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Biomedical subjects

A Zachariassen

Publications and source records attributed to A Zachariassen.

7 recordsLinked to original sources
PubMed1990

The implications of introducing the symphyseal-fundal height-measurement. A prospective randomized controlled trial.

A total of 1639 women attending the antenatal clinic of Gentofte University Hospital, Copenhagen, during 1986-1987 was randomized into a symphyseal fundal (SF)-group and a control group. The women in the SF-group had their fundal height measured from the 29th week until delivery. The measurements were used along with the other usual screening procedures. The SF-measurements were not found helpful in the prediction of small-for-gestational-age infants and no significant differences were found between the two groups regarding the number of interventions, additional diagnostic procedures, or the condition of the newborns.

Denmark↗
PubMed1989

No effect of topical ampicillin prophylaxis in elective operations of the colon or rectum.

Whether or not topical application of ampicillin is necessary in patients undergoing elective colorectal operations was investigated. After mechanical preparation, 193 patients received 2 grams of cefotaxime administered intravenously from the start of the operation; patients received two more doses within the next 12 hours. In addition, patients were randomized to receive or not receive prophylaxis against infection of 2 grams of ampicillin in the site of the incision at closure. Twenty-three patients did not complete the study. Wound infection occurred in five of 81 patients who had topical application of ampicillin compared with six of 89 patients who did not receive prophylaxis; the difference was not significant. There were no significant differences in rates of wound dehiscence, intra-abdominal abscess or anastomotic leakage. Escherichia coli and Bacteroides fragilis were the predominant microorganisms isolated. Thus, topical application of ampicillin did not lower the wound infection rate when there was a preoperative antibiotic administered intravenously.

Administration, Topical↗
PubMed1989

Single-dose versus six-day therapy with sulfamethizole for asymptomatic bacteriuria during pregnancy. A prospective randomised study.

Single-dose versus conventional six-day therapy with sulfamethizole for asymptomatic urinary tract infection in pregnant women was investigated in a prospective, randomised open study. During a nine-month period 4,274 pregnant women were screened for significant bacteriuria, which was found in 123 (2.9%), of whom only five had symptoms of urinary tract infection. Seventy-nine of the patients had a second urine culture performed, revealing significant counts of the same bacteria in only 41. These 41 patients were randomly allocated to one of the two treatment groups. Control urine cultures one week and 4-6 weeks after start of treatment revealed the same cure rates of approximately 50% in both groups. Single-dose treatment is not inferior to conventional therapy; future study is needed to find the best single-dose regimen.

Bacteriuria↗
PubMed1980

Acute relief of epigastric pain by antacid in duodenal ulcer patients.

Thirty-six duodenal ulcer patients participated in a randomized controlled trial of the immediate effect of a liquid antacid preparation (Link) and placebo on epigastric pain. The patients recorded the effect of a total of 143 doses of antacid and 148 doses of placebo. Marked or complete relief of pain 30 min after ingestion was found after 62% of the antacid doses and after 52% of the placebo doses. The average effect of antacid was better than the effect of placebo in 21 patients, worse in 8 and equal in 7 patients. This difference in favour of antacid is statistical significant (p less than 0.05) and therefore it is concluded that antacid is more effective than placebo in relieving epigastric pain in duodenal ulcer patients, although the therapeutic gain is small.

Antacids↗