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A Zajdela

Publications and source records attributed to A Zajdela.

34 records · Page 2Linked to original sources
PubMed1979

[Value and interest of fine needle aspiration cytology in the follow-up of irradiated breast cancers (author's transl)].

Between 1968 and 1975, the authors studied at the Institut Curie the value of fine needle aspiration cytology in the follow-up of breast cancers, which have been previously treated with definitive irradiation (182 cases) or lumpectomy and post-operative irradiation (20 cases). The cytologic results have been compared to the pathologic aspects of the surgical specimens. The cytologic procedure was made when the tumor decrease was incomplete or too slow, or when, after a free interval, was noted in the irradiated breast a tissue reaction clinically and radiologically indefinite. The post-therapeutic investigation interested 202 cases of breast carcinoma. Compared to the histologic result, the cytologic results proved to be: -- identical. . . . . . . in 170 cases (84%) -- false benign . . . . . in 4 cases (2%) -- false malignant . . . . in 4 cases (2%) -- insufficient cell material in 24 cases (12%) The high rate of correct cytologic diagnosis and the very low rate of wrong results prove the value and interest of the fine needle aspiration cytology for residual tumor masses or for recurrences in irradiated breast cancers.

Biopsy, Needle↗
PubMed1977

[Basocellular epithelioma of the back with metastases of the axillary ganglia].

In a 52-year old woman, basal cell carcinoma of the back skin recurs after excision and the axillary lymph nodes are involved. This case is to be added to the list of basal cell carcinomas with metastatic evolution. The histologic study of a series of sections allows to show the migration of neoplastic cells in the vessels. Though exceptional, the ability of the basal cell carcinomas to yield metastases must be taken into account.

Axilla↗
PubMed1975

The value of aspiration cytology in the diagnosis of breast cancer: experience at the Fondation Curie.

Aspiration cytology was performed on 2772 breast masses, all of which subsequently had open biopsies. Of the 1745 histologically malignant tumors, 1539 (88%) had a concordant cytologic diagnosis: 54 (0.3%) were diagnosed as probably malignant; 63 (3.6%) were false negatives; and 80 (0.5%) had inadequate smears for diagnosis. Of the histologically benign lesions, 916 (89%) had a concordant cytology: only 3 (0.3%) were false positives; cancer was suggested in 42 (0.4%); and the smears were inadequate in 66 cases (6.4%). Very small or very large sized cancer and a high degree of differentation were major causes of false negative aspirates. Recurrent tumors in those breasts exclusively treated by radiotherapy were documented by cytology in 56 of 69 cases (78%). Aspiration cytology is highly reliable when the diagnosis of cancer is made, but should be ignored if no malignant cells are observed.

Biopsy, Needle↗
PubMed1975

[Cytological examination. Solid breast tumors examined by means of fine-needle puncture].

The value of cytological diagnosis of solid tumours of the breast where the cells were obtained by suction aspiration through a needle has been analysed in a consecutive series of 2,401 cases, all of which were checked by histological examination. They consisted of 1,745 malignant tumours and 656 benign tumours. The cytological diagnosis of malignancy was confirmed, almost always, error being practically non-existent (4 out of 1,000). This confirms that this simple and rapid test is very valuable in the diagnosis of mammary cancer. On the other hand, when the diagnosis of a benign tumour was made a certain number of cancers were missed (3.6 per cent). This is not therefore as valuable a test when the result is negative as when the result is positive. All the same, in certain cases it can suggest the diagnosis without giving the precise type of lesion, which can only be finally diagnosed histologically.

Azure Stains↗
PubMedDate not supplied

Cytologic diagnosis of orbital and periorbital palpable tumors using fine-needle sampling without aspiration.

Sixty-two cases of orbital and periorbital palpable neoplasms were analyzed cytologically. The material was obtained by our technique of simply introducing a fine injection needle in the tumor mass without aspiration. Fifty-six of these tumors had a subsequent histologic diagnosis by surgical procedure or biopsy. Forty-nine of the 56 cytologic diagnoses (87%) were concordant with the histologic findings with regard to malignancy and its variety. In three other cases the diagnosis of malignancy was only achieved by surgical procedure or biopsy (5%). In two cases, there were false-malignant results (4%), one corresponding to a meningioma and the other related to a reactive lymphoid hyperplasia. There was one false-benign (2%) result in a case of non-Hodgkin's lymphoma. In one patient, the cytologic material was insufficient for diagnosis (2%). In six other cases, the initial cytologic examination was ultimately confirmed either by biochemical studies or by biopsies of nodal metastases. No orbital hemorrhage was observed after fine-needle sampling. This outpatient technique is highly accurate and permits diagnosis in a few minutes.

Biopsy, Needle↗
PubMedDate not supplied

[Value of the cytologic diagnosis of adenopathies by aspiration biopsy. Cytohistologic comparison of 1756 cases].

The value of the cytologic diagnosis by aspiration needle biopsy is analysed in a series of 1756 adenopathies, verified by histological examination (1311 malignant nodes and 445 inflammatory or normal lymph nodes). The result is that a large number of lymph node tumours, either primary or secondary, are identified by the cytologic examination (from 77% to 91% of the cases according to the explored zone). Furthermore the virtually non existent percentage of false positive results (3% of the cases) proves the great accuracy of this method in the diagnosis of malignancy. In contrast, the diagnosis of benign nature must never be stated without biopsy (2% to 4% of the cases are erroneous by negative according to the explored zone). Indeed, even if benign cells are obtained, nothing allows to eliminate a malignant tumour or a limited inflammatory zone, not reached by the needle.

Axilla↗
PubMedDate not supplied

[Cytological aspects of various particular varieties of breast epitheliomas].

Needle aspiration for cytological investigation has been used at the Foundation Curie since 1954. Until 1973, no less than 3,176 mammary tumours have been studied by this method and comparison made with the histological findings. In the whole group some relatively rare carcinomas have been encountered -- mucoid, medullary, adenoid cystic, squamous and apocrine. Each category is described from the cytologic viewpoint and illustrated with an appropriate cyto/histologic example to show what a high degree of precision may be attained by diagnostic cytology in mammary cancer.

Adenocarcinoma, Mucinous↗
PubMedDate not supplied

[Cytology of various rare benign tumors of the breast].

The authors describe the cytological appearances of three rare benign mammary tumors (granular cell myoblastoma, sebaceous cyst and fibrous histiocytoma), and warn the clinician against over-optimism when presented with a benign cytologic diagnosis. In fact, the proportion of cases in which carcinoma is confused with a benign tumour varies from 3 to 5% according to statistics. They analyse the various causes responsible for the "false benign" diagnosis. The author's opinion is that one can only arrive at the cytological diagnosis of benignity as part of a group of investigations. Final diagnosis must depend upon a histological examination.

Breast Neoplasms↗
PubMedDate not supplied

The relation of prognosis to the nuclear diameter of breast cancer cells obtained by cytologic aspiration.

Nuclear diameters of breast cancer cells obtained by aspiration cytology from 245 patients were measured by ocular micrometry. The nuclei of 50 benign lesions were also measured. Cancers with 80% or more of their nuclei larger than 12 mu were classified as "large nuclear type" (LN). Those with nuclei of 12 mu or less were considered "small nuclear type" (SN). One hundred forty-nine cases of the former and 96 of the latter were evaluated. There was significant overlap in nuclear diameter of benign lesions and SN cancers but minimal overlap between SN and LN cancers. Thirty-eight percent of SN cancers were staged as T1 as compared to only 20% of LN tumors. Survival, free of disease, at five years was 90% for the SN cancers and 58% for the LN cancers (p less than 0.001). Intervals between completion of treatment, appearance of metastases and death were longer for patients with SN cancers. Measurement of nuclear diameters of cells obtained by aspiration cytology may, therefore, be useful in determining the prognosis.

Adult↗