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A Zapletal

Publications and source records attributed to A Zapletal.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Lung function abnormalities in cystic fibrosis and changes during growth.

Static lung volumes (VC, TLC, FRC, RV), elastic recoil pressure of the lungs (Pst(1) at 100, 90, and 60% of TLC), static lung compliance [Cst(1)], specific airway conductance at FRC level (Gaw/TGVex), forced expiratory volume in the first second (FEV1), maximal expiratory flows (Vmax.) at 25 and 50% of VC and at 60% of TLC, and "upstream" airway conductance (Gus) at 60% of TLC were studied in 28 patients with cystic fibrosis, 5 to 25 years old, over a period of 1 to 5 years. The data were compared individually with normal values, related to body height in the form of regression equations and expressed in percentage of predicted values. From the indices assessing airway function, Vmax. at low lung volumes, Gus at 60% TLC, RV and RV/TLC were the functional parameters most consistently abnormal. Among the indices characterizing lung elasticity, Pst(1) at 60% TLC was the most abnormal. Generally, the values of the majority of lung function indices [VC, TLC, FRC, Pst(1)] declined during growth. Vmax. at all lung volumes and Gus at 60% TLC did not deteriorate with growth probably due to the great abnormality of these parameters already in young patients. It was also observed that lung function did not change significantly over a period of 1 to 5 years corresponding to a 10 cm increase in body height. However, over that period, lung function improved in some of the subjects, did not change in over 50% of the cases and deteriorated in the others.

Adolescent↗
PubMedDate not supplied

Upstream and total airway conductance in children and adolescents.

Static lung volumes, pressure-volume curves, airway conductance (Gaw) and maximum expiratory flow-volume curves were obtained in a group of healthy children and adolescents (age 6 to 17 years, body height 115 to 180 cm). Relating lung recoil pressure to maximum expiratory flow at the same lung volume level allowed the calculation of the conductance of the upstream segment (Gus). Gaw increased with increased body height and lung volume, so that specific Gaw did not change during growth. Gus also increased with body height, except at lower lung volume, but when corrected for simultaneous changes in lung volume it decreased. These physiological results suggest that the central airways grow proportionately to the changes in lung volume, whereas the growth of the peripheral airways is proportionately less marked. It is however not possible to draw definite conclusions on the isotropical or anisotropical growth of different parts of the lungs from these physiological observations.

Adolescent↗