Biomedical subjects

A Zebrowski

Publications and source records attributed to A Zebrowski.

At least 19 recordsLinked to original sources

PubMed1995

[Chronic inflammation of the gastric mucosa and some immunologic aspects of Helicobacter pylori infection].

UNLABELLED: The aim of the study was to determine what is the correlation between immunological phenomena and pathological changes in chronic gastritis and how it refers to the histology and endoscopy. PATIENTS AND METHODS: 42 patients with dyspepsia underwent following procedure: 1) gastroscopy and antral biopsy of 3 specimens; 2) histology; 3) immunofluorescence of the specimens in purpose to detect bound immunoglobulins using antibodies anti-human IgA + IgG + IgM labelled with rhodamine; 4) serologic test for anti-H.pylori antibodies. The research included 17 females and 25 males (ages 30-86, median 53.4 +/- 15.47). The obtained data were compared referring to mutual correlations and presented according to the kind of pathological changes depending on:--presence or absence of Helicobacter pylori infection;--presence or absence of anti-Helicobacter pylori antibodies;--presence or absence of lymphocytic infiltration;--presence or absence of bound immunoglobulins in gastric mucosa. RESULTS: --We have not observed ulcerations in anti-Helicobacter pylori seronegative group;--intestinal metaplasia and gastric ulcer were more frequent in bound immunoglobulins positive group;--biliary reflux was observed less frequently in lymphocyte infiltration negative group then in the positive one. CONCLUSION: pathological changes in chronic gastritis may depend not only on the presence of Helicobacter pylori infection, but also on the presence and quality of immunological response on its antigens.

Adult↗

PubMed1993

[Immunologic aspects of allogenic valve implantation].

Immunological response against myocardial antigens was assessed in 12 patients (pts) (9 males, 3 females, aged 24-62 years) with aortic homografts (AH) and 36 pts (29 males, 7 females, aged 26-61 years) with aortic valve prostheses (AVP). In all pts a titre of anti-myocardial antibodies, a concentration of free-circulating immune complexes and leucocytes migration inhibition test with myocardial antigen were assessed before operation and 1, 12, 24 months after operation. In 20 pts with AH immunological humoral response against HLA antigens was evaluated. After the operation pathological indexes of immunological response against myocardial antigens were observed both in pts with AH as in pts with AVP. The mean titre of anti-myocardial antibodies before operation was in both groups between 1:4 and 1:8, and 1 month after operation between 1:32 and 1:64. In 12 and 24 months after operation the mean titre in AH and AVP group was respectively 1:8 and 1:4. Before operation pathological concentration of immune complexes (> 0.084 mg/ml) was observed in 17% AH and 11% AVP pts. Pathological elevation of immune complexes 1, 12 and 24 months after operation was observed respectively in AH and AVP group in 58%, 42%, 33% and 67%, 50%, 42%. Leucocyte migration inhibition index was pathological (< 0.8) before operation in 58% in both groups, and 1, 12, 24 months after operation was pathological in AH and AVP group respectively in 67%, 17%, 17% and 61%, 33%, 31%. In most pts of both groups immunological response against myocardial antigens was transient and was terminated up to 12-24 months after operation.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1991

[HLA histocompatibility antigens in patients with aortic valve defects].

HLA antigens A, B, C were determined in 61 patients with aortic valve disease and in 263 healthy controls. The patients were divided into two subgroups--with rheumatic fever in anamnesis (N = 24) and without (N = 37). In the whole group of patients with aortic valve disease there was a lower frequency of incidence of HLA A3 in comparison to the control group. In the subgroup with rheumatic fever in anamnesis there was a deficit of HLA A3 and a much more frequent incidence of HLA B17, in the subgroup without rheumatic fever a more frequent incidence of HLA A2, A9, A28, B15 was noted in comparison to the control group. This study shows that in 60% of patients with aortic valve disease the etiology is linked not to rheumatic fever but probably to a connective tissue disorder. A deficit of HLA A3 and presence of B17 can be a risk factor for rheumatic fever.

Adult↗

PubMed1990

[Transvenous ablation of the conduction under fluoroscopic control in a case of refractory supraventricular arrhythmia].

Transvenous ablation of atrioventricular (AV) junction is an accepted method for treatment of refractory supraventricular arrhythmias. In the classic method the proper position of the ablation electrode is based on registration of the potentials of the conduction system. However according to Bredykis et all. Localization of the catheter is also possible under fluoroscopic control. The study presents a 67-year old patient with recurrent supraventricular tachycardias. Repeated bouts of arrhythmia, refractory to various antiarrhythmic drugs, caused severe hemodynamic consequences. Several cardioversions were performed for arrhythmia termination. Electrophysiologic study using transesophageal pacing showed a concealed accessory pathway conducting only in retrograde direction and the patient was designated for transvenous ablation of AV junction. The specially developed 6F USCI electrode with enlarged tip was used. The catheter was introduced into the right ventricle under fluoroscopic control and then slowly withdrawn until the tip was placed within the tricuspid valve at the border of atrium and ventricle. Cathodal pole of the defibrillator was connected with the electrode. Then the procedure was similar to the classic ablation. Single 200 joules DC shock caused complete AV block. No complications were seen during and after the procedure. A permanent cardiac pacemaker was implanted at the 4th day after ablation. The patient was doing well, without medication and no arrhythmias were observed during the 9 month period. The AV block persisted stable, also retrograde conduction was absent.

Aged↗

PubMed1988