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Biomedical subjects

A Ziada

Publications and source records attributed to A Ziada.

7 recordsLinked to original sources
PubMed2001

Blood pressure and its reactivity in the offspring of first cousin hypertensive and first cousin normotensive parents: a preliminary report.

The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9-10 years was measured, for the first time ever, after a 10-min supine rest, and subsequently, twice at 10-min intervals. The offspring of first cousin hypertensive parent(s) reacted with significantly higher systolic and diastolic BP than the offspring of normotensive first cousin parents in all three measurements. This study indicates that at an early age, the offspring of first cousin hypertensive parents, react with exaggerated BP response at their first casual BP measurement. We hypothesise that familial aggregation of BP may show more expression amongst the offspring of consanguineous marriage of hypertensive parent(s).

Blood Pressure↗
PubMed2000

Advanced prostate cancer: an update.

A number of therapeutic options are available or on the horizon for patients for whom initial treatment of localized prostate cancer has failed. Currently under study are time of therapy, maximum androgen blockade, and palliative and adjunctive therapies.

Journal Article↗
PubMed1999

Combined androgen blockade for advanced prostatic carcinoma.

Hormonal therapy has been mainstay of treatment for advanced forms of prostate cancer for over 50 y. The choice of hormonal therapy for carcinoma of the prostate depends not only on the desired progression-free and overall survival but also on the patient's quality of life, treatment costs and treatment toxicities. At the present time, several important questions have been raised over optimal treatment modalities for advanced prostate cancer. The optimal form of this therapy is still an enigma.

Journal Article↗
PubMed1989

The effect of long-term administration of alpha 1-blocker prazosin on capillary density in cardiac and skeletal muscle.

The effect of prazosin on heart and muscle blood flow and capillary density was studied in rats. In acute experiments, alpha 1-blocker prazosin almost trebled blood flow in fast skeletal muscles [tibialis anterior (TA) and extensor digitorum longus (EDL)], but did not affect coronary flow when infused i.v. at a dose of 0.5 microgram.ml-1.min-1 for 30 min. Prazosin in an equivalent dose was then given orally over a period of 5 weeks to investigate its effect on capillarisation in heart and skeletal muscle. Capillary density (CD, capillaries.mm-2), estimated in frozen sections stained for alkaline phosphatase, was similar in the hearts of prazosin-treated and control rats. Capillary/fibre ratio in skeletal muscles increased from 1.52 +/- 0.019 in control EDL to 1.69 +/- 0.01 (P less than 0.001) and from 1.56 +/- 0.04 in control TA to 2.16 +/- 0.04 (P less than 0.001). In TA, the increase was greater than in EDL both in the glycolytic periphery (from 1.30 +/- 0.13 to 1.75 +/- 0.11, P less than 0.025) and the oxidative core of the muscle (from 1.837 +/- 0.14 to 2.51 +/- 0.12, P less than 0.005). Unilateral crush of the lateral peroneal nerve and subsequent reinnervation over the next 7 weeks resulted in redistribution of fibre types from a typical mosaic pattern into groups composed of fibres of similar oxidative capacity. Capillary density as well as capillary/fibre ratio in purely glycolytic areas was lower when compared to supply of glycolytic fibres in normal muscles.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗