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A Zibetti

Publications and source records attributed to A Zibetti.

14 recordsLinked to original sources
PubMed1979

[Visual evoked potentials and the E-UFA test. Laboratory contribution to the diagnosis of multiple sclerosis].

Visual evoked potentials (VEPs) and electrophoretic mobility test of erythrocytes (E-UFA test) were compared in 50 multiple sclerosis (M.S.) patients as diagnostic tests. Abnormal VEPs were recorded in 35 patients. E-UFA test was found positive in 31 cases. With respect to Mc Alpine diagnostic criteria, 26 out of 33 definite M.S., 6 out of 9 probable M.S. and 3 out of 8 possible M.S. cases had abnormal VEPs. A positive response in E-UFA test was observed rispectively in 16, 8, 7 patients. Complessively 48 cases (96%) had an abnormal response to the one and/or to the other of the two tests, which apper complementar in early diagnosis of M.S.

Adolescent↗
PubMed1979

Erythrocyte unsaturated fatty acid test (E-UFA test): a biological test to detect optic neuritis as initial feature of multiple sclerosis.

Retrobulbar optic neuritis, though suspicious is not always considered as a possible onset of MS. For this reason we submitted to the E-UFA (erythrocyte unsaturated fatty acid) test, 41 subjects who suffered from one or several episodes of retrobulbar optic neuritis with no other neurological signs. The test was positive in 14 subjects (34, 1%).

Adolescent↗
PubMed1978

2 [(methylsulfinyl) acetyl] pyridine (Oxisuran): a new immunosuppressive agent in EAE.

The authors discuss the effects of a new immunosuppressive agent on the development of EAE. Animals (albino rabbits) were inoculated with an encephalitogenic emulsion, according to Kies' method, whereas a control group was inoculated by a physiological saline solution. Some animals were treated by Oxisuran in the first day after challenge; some others after initial symptoms (18th day). Thirty days after challenge, the animals were sacrificed. No toxicity was found in thoracic and abdominal structures neither in blood count. Pharmacological effectiveness of Oxisuran is well documented either in pretreatment or in therapy; the course was positively influenced in animals, when treated after the appearance of initial symptoms.

Animals↗
PubMed1978

HLA typing on Italian multiple sclerosis population.

Considerable evidence suggests the existence of significant differences of HLA distribution between M.S. patients and normal healthy subjects of the same population. In the present work we investigate whether the antigen DW2 may be a better marker for M.S. than the specificities at the loci A and B by means of in vitro one-way mixed lymphocyte cultures.

HLA Antigens↗
PubMed1978

E-UFA test in multiple sclerosis.

Field et al. have recently suggested a blood test for multiple sclerosis based on determination of the absolute electrophoretic mobility of erythrocytes alone and in the presence of linoleic acid (LA) or arachidonic acid (AA). We attempted to reinvestigate this phenomenon in an Italian population.

Arachidonic Acids↗
PubMed1978

Study of the relationship between rubella virus and encephalitogenic factor in experimental allergic encephalomyelitis.

The Authors research in the sera of 30 rabbits affected by E.A.E. the connection between encephalitogenic factor and rubella virus. They dose the antibodies against rubella virus and encephalitogenic factor before the challenge by BP, after 15 days and after 30 days. While in the first control no response either to the virus or to BP was evidenced, in the two following controls, the sera of the rabbits recognized immunologically both rubella virus and the myelinic components.

Animals↗
PubMed1977

HLA-A3 linked C3 deficiency in multiple sclerosis.

Many workers claim variations in quantity of functional activity of several components in the complement system in M.S. patients. Studies were performed in 58 M.S. patients, typing for HLA-SD specifities and C'3 complement component. We have been able to confirm a significant correlation between the hypocomplementaemic group (31.03%) with HLA-A3. In this connection we present some considerations on complement system and M.S.

Complement C3↗
PubMed1975

N1-Methylnicotinamide urinary output in multiple sclerosis affected patients.

This brief report develops the ideas of some previous works underlying a possible functional disequilibrium of tryptophan metabolism in patients affected by Multiple Sclerosis (M.S.) and in animals with experimental allergic encephalomyelitis. So, the urinary excretion of one of the terminal metabolites of the kynurenine pathway of tryptophan, the N1-Methylnicotinamide has been confronted in M.S. patients and in healthy volunteers, in order to put in evidence a possible alteration of the same in M.S. patients. The A.A. could not find any significant difference of the N1-Methylnicotinamide urinary output between controls and M.S. patients; afterwards they have critically revised this result.

Adult↗
PubMedDate not supplied

[Biochemical aspects of lipid metabolism in multiple sclerosis].

The biochemical features of lipid metabolism in multiple sclerosis are discussed and the contribution made by work on the aetiopathogenesis of the disease is illustrated. Reference is made to diagnostic tests (E-UFA and MEM tests), whose premisses are based on lipid metabolism. A link between biochemical and immunological research in this field is put forward.

Arachidonic Acids↗