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In this experimental contribution to the study of neurobiological interactions between adrenal medullary graft and CNS, is presented a model to estimate the approaches to rat adrenalectomy using statistical inference techniques. Eighteen rats were divided into three samples. The members of every sample were left adrenalectomized using lombotomic, anterior transperitoneal and posterior approaches respectively. A score was attributed to every experimentally meaningful parameter, according a previously well established plan. Scores were tested by analysis of variance and by previously planned orthogonal comparisons. Mean, standard deviation of every sample score and confidence interval for mean difference were computed. Statistical analysis results show that, objectively, there is a meaningful difference between anterior approach and posterior or lateral approach, anterior approach being more difficult then posterior or lateral approach, while there is not meaningful difference between posterior and lateral approach. Subjectively, on the contrary, there are not meaningful differences between three approaches to left adrenalectomy statistically.