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A Zober

Publications and source records attributed to A Zober.

43 records · Page 3Linked to original sources
PubMed1976

[Clinical-chemical diagnosis of poisoning].

There is a disparity between the number of reported cases of poisoning and the number of chemical analyses performed for the identification and quantitative determination of a particular poison. The aim of the workshop conference was to clarify the extent to which different clinics possess or require the necessary facilities for the investigation of poisons. The following summary of 16 lectures and accompanying discussion puts into perspective the present state of clinical toxicological analysis. Guide lines for the further development of clinical-toxicological analysis are formulated in the final discussion, where a plan is proposed for the incorporation of toxicological analysis into clinical chemistry.

Evaluation Studies as Topic↗
PubMed1975

[Determination of fluoride in bone samples from human iliac crest with an ion-specific electrode (author's transl)].

A simple potentiometric method for the determination of fluoirde ion in human bones is described. The bone samples were taken from a definite position in the iliac crest. The samples are prepared for analysis by ashing at 550 degrees C, dissolving in HNO3 (4 mol/1) and adjusting the pH with NaOH (4 mol/1) and Total Ion Strength Adjustment Buffer, Absolute values are derived from a calibration curve based on aqueous NaF-buffer solutions. The calibration curve is linear in the range 5.2-10(-3)-1.0-10(-5) mol/1F-. The minimum limit of measurement is 5.2 X 10(-6) mol/1F-. The method has an accuracy of 96.1 % or 92.3% with a series precision based on the Pearson variability coefficient of 1.68%. The normal mass fraction of fluoride in human bones was found to be between 69 and 1740 - 10(-6) F-/ash.

Bone and Bones↗
PubMedDate not supplied

Laboratory results for selected target organs in 138 individuals occupationally exposed to TCDD.

Blood specimens for dioxin congener analysis and clinical laboratory studies were recently obtained for 138 employees who had been potentially exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) following a 1953 trichlorophenol autoclave accident. Results for 34 clinical tests were regressed on three exposure measures (current TCDD concentration, log TCDD concentration back-calculated to the time of exposure, and chloracne status). Age, smoking status and body-mass-index were included as additional explanatory factors in the analyses. Positive associations were found between each of the exposure measures and both serum thyroxine (T4) and thyroxine binding globulin (TBG). Additional exposure-response associations were detected relative to several immune system parameters, erythrocyte sedimentation rate, platelet count and serum alkaline phosphatase. These data will be specifically helpful in interpreting the results of additional morbidity and mortality studies conducted within the same target population.

Blood Glucose↗
PubMedDate not supplied

BASF studies: epidemiological and clinical investigations on dioxin-exposed chemical workers.

First in 1953 and again later in 1988, BASF Aktiengesellschaft, Ludwigshafen, Germany, faced production-related dioxin contamination problems. In both situations, the immediate actions were efforts to limit the potential for employee exposure. In 1953, after a reactor accident, the production of trichlorophenol was stopped and extensive clean-up and demolition work was undertaken. In 1988, major technical improvements were made to an extrusion blending process and the flame retardants were changed to substances that chemically should not be dioxin precursors. The health experience of the potentially exposed populations has been followed extensively in both situations. Five recent epidemiological investigations: a long-term mortality follow-up, a morbidity study, a clinical laboratory study, and a chromosome study of persons from the 1953 accident cohort, as well as immunological studies of employees assigned to the extrusion operations, are discussed. In addition, considerable dioxin biomonitoring data from blood lipids for both populations are summarized.

Chromosome Aberrations↗