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Biomedical subjects

A al-Dawoud

Publications and source records attributed to A al-Dawoud.

6 recordsLinked to original sources
PubMed1993

Focal pancreatic infarction in pheochromocytoma.

A 21-year-old man presenting with jaundice and hypertension was found to have an extraadrenal pheochromocytoma. Cholangiography demonstrated a cavity in the head of the pancreas that was in communication with both the pancreatic and common bile ducts. Hemorrhage from the cavity led to the patient's death and postmortem examination revealed focal infarction of the pancreatic head. This case adds hemobilia, obstructive jaundice, and focal pancreatic infarction to the list of bizarre remote manifestations of pheochromocytoma.

Adrenal Gland Neoplasms↗
PubMed1992

Immunohistochemical analysis of mucosal gamma-interferon production in coeliac disease.

The role of gamma-interferon in the pathogenesis of enteropathies with an immunological basis such as coeliac disease, is unclear. Gamma-interferon immunoreactive lymphocytes were quantified in jejunal biopsies from patients with coeliac disease and from normal controls. In coeliac disease, there was an apparent decrease in the percentage of both intraepithelial (3.5% v 13.5%) and lamina propria (10.3% v 47.2%) lymphocytes expressing gamma-interferon compared with controls. In patients successfully treated with a gluten free diet, the percentage of gamma-interferon immunoreactive intra-epithelial lymphocytes was 10.3%. Intraepithelial lymphocytes were immunonegative for class II major histocompatibility complex, while epithelial cells showed increased expression of this product in coeliac disease. The results show that a relatively large proportion of lymphocytes in normal small bowel express gamma-interferon. They also indicate that in coeliac disease the major increase in the numbers of mucosal lymphocytes is the result of infiltration by lymphocytes not expressing gamma-interferon.

Adolescent↗
PubMed1992

Extrapulmonary small cell carcinoma of bone.

Small cell carcinoma has been reported to arise in many extrathoracic sites. However, such tumours arising from bone have not been previously described. We report what we believe is the first reported case of extrapulmonary small cell carcinoma of bone. The tumour arose from the fifth dorsal vertebra in a 60 year old woman. The patient was treated with local radiotherapy and combination chemotherapy and remains in remission, 18 months after diagnosis. As such extrathoracic small cell tumours are rare, there seem to be no clear-cut guidelines for treating them, but combination chemotherapy is recommended.

Antineoplastic Combined Chemotherapy Protocols↗