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Biomedical subjects

A de Candia

Publications and source records attributed to A de Candia.

5 recordsLinked to original sources
PubMed2003

Lattice glass model with no tendency to crystallize.

We study a lattice model with two-body interactions that reproduces in three dimensions many features of structural glasses, such as cage effect and vanishing diffusivity. While having a crystalline state at low temperatures, it does not crystallize when quenched, even at the slowest cooling rate used, which makes it suitable to study the glass transition. We study the model on the Bethe lattice as well, and find a scenario typical of p-spin models, as in the Biroli-Mézard model.

Journal Article↗
PubMed2003

Percolation, morphogenesis, and burgers dynamics in blood vessels formation.

Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.

Computer Simulation↗
PubMed2002

Off-equilibrium response function in the one-dimensional random-field Ising model.

A thorough numerical investigation of the slow dynamics in the d=1 random-field Ising model in the limit of an infinite ferromagnetic coupling is presented in this paper. Crossovers from the preasymptotic pure regime to the asymptotic Sinai regime are investigated for the average domain size, the autocorrelation function, and staggered magnetization. By switching on an additional small random field at the time t(w) the linear off-equilibrium response function is obtained, which displays as well the crossover from the nontrivial behavior of the d=1 pure Ising model to the asymptotic behavior where it vanishes identically.

Journal Article↗
PubMed1996

Arthroscopic synovectomy in rheumatoid and psoriatic knee joint synovitis: long-term outcome.

A long-term prospective study was performed to evaluate the safety and long-term outcome of surgical arthroscopy (AS) for persistent rheumatoid (RA) and psoriatic (PsA) knee joint synovitis (KJS). Local signs of joint inflammation (tenderness, swelling, "ballottement') and range of motion (ROM) were scored and the sum, taken as a global outcome measure, was recorded in 17 RA and 18 PsA knees, both before and at follow-up periods of 2, 6, 12, 24 and 36 months after surgical AS (knee joint synovectomy; meniscal curettage, cartilage shaving or chondrectomy, according to the degree of cartilage damage). A survival analysis (Kaplan-Meier) of the long-term outcome of surgical AS treatment and of the predictive value of clinical parameters of knee joint involvement was also performed. No intra- or post-operative morbidity, pain worsening or loss of joint motion was observed and all patients were discharged within 48 h. Comparison of the parameters of knee joint evaluation showed a significant reduction of the signs of joint inflammation and a significant increase in the ROM in all follow-up periods. At 36 months, the survival curves showed a 61.2% cumulative probability of clinical remission and 72.8% of definite improvement. No significant differences in the prognostic importance of RA, compared to PsA diagnosis, were observed, although higher percentages of PsA compared to RA knees (86.3% and 45.7% respectively) reached the end point of clinical remission at 36 months. KJS duration, radiographic severity and cartilage damage were not predictors of poor long-term outcome of AS synovectomy. Surgical AS treatment for PsA knees with more advanced cartilage damage gave a better long-term outcome. A total of 50.7% of operated knees reached the end point of a KJS relapse at 36 months, the majority (82%) within the initial 18 months of follow-up. Our study indicates that AS synovectomy is a safe procedure requiring short hospitalization which, in combination with second-line medical treatment, can reduce local inflammation in RA and PsA KJS, and preserve knee joint ROM for up to 3 yr.

Adult↗