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Biomedical subjects

A de Coninck

Publications and source records attributed to A de Coninck.

At least 19 recordsLinked to original sources
PubMed1993

Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers.

BACKGROUND: Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers. OBJECTIVE: Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers. METHODS: Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment. RESULTS: No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different. CONCLUSION: CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs.

Adult↗
PubMed1988

Congenital ring-constriction syndrome of the limbs; a report of 19 cases.

The authors report 19 cases of congenital ring-constriction syndrome of the limbs. Complications arose in eight of the pregnancies. The limb anomalies were always congenital ring-constrictions together with distal amputation. Moreover, 13 patients also had syndactyly and 15 associated anomalies were registered in 9 patients--8 of the limbs, 3 craniofacial and 4 visceral. One patient had a family history of hypospadias and cardiac malformation. Treatment usually required several operations, staged Z-plasty being the procedure of choice in surgical release of constriction bands. The acrosyndactylies were released early in life. More extensive fusions required division and skin grafting even if the webs did exist. The aetiology of the condition is still under discussion. The number of cases in the literature that cannot be explained by the exogenous theory of the congenital ring-constriction syndrome is increasing. Among them are four cases in our series.

Abnormalities, Multiple↗
PubMed1986

Tumor of the hypopharynx: free jejunal transfer with conservation of the larynx: a case report.

Resection of the hypopharynx or cervical esophagus for malignancy is always quite mutilating if reconstruction cannot be achieved with a one-stage procedure. Several techniques have been described, but they are often associated with laryngectomy. In the case reported, a free split jejunal segment transfer allowed reconstruction of the hypopharynx without laryngectomy, as the malignancy did not involve the larynx.

Humans↗
PubMed1985

Hand injuries caused by high pressure injection. Contribution of loco-regional anaesthesia.

In a reported case of accidental high pressure injection of white spirit into a finger, the authors emphasise the great contribution of regional anaesthesia maintained from the initial trauma until the lesions are stable. Trauma to the hand caused by injection of paint or grease solvents results in tissue destruction and later necrosis and fibrosis. Secondary amputations are required in many cases. Regional anaesthesia of the stellate ganglion and brachial plexus produces analgesia and vasodilatation of peripheral arteries by inhibition of the sympathetic tone. This vasodilatation limits the necrotic process and promotes the supply of drugs to the injured tissues. Regional anaesthesia is of great benefit for surgical excision and avoids extended amputation.

Adult↗
PubMed1984

[Use of a vein segment in peripheral nerve repair].

The authors describe a new technique of nerve repair based on the utilisation of a venous sleeve to isolate and to contain the severed nerve during the period of cicatrisation. The histological pattern of the venous wall and its reaction to the regenerated nerve have been studied. Electrophysiological techniques, confirmed by histological studies, have demonstrated the good quality of the anastomosis. The utilisation of a venous sleeve allows for nerve repair without synthetic suture material. The dimensions of anastomotic neuroma are reduced, and are smaller than in other techniques of suture. The possibility of isolation of neuroma by the vein, even in the case of terminal neuroma, is equally worth consideration.

Animals↗
PubMed1983

[Perforating plantar ulcer. Interfascicular neurolysis of the posterior tibial nerve].

The authors report the case of a 45-year-old man with perforant ulceration of the foot. The rapid evolution of the cutaneous and bone lesions (three years) necessitated a bilateral intermetacarpo-phalangeal amputation. After conventional therapy, a large necrotic zone remained on the sole of the left foot as well as hyperkeratosis of the right foot. Following Bourrel's protocol for the treatment of leprosy, the authors proposed a posterior tibial nerve neurography, which confirmed the compression of the nerve in the tarsal tunnel. In addition, histological examination of the nerve branches of the sole of the foot showed fibrous thickening of the nerve, endoneural invasion by fibroblasts, and loss of myelin. An interfascicular neurolysis of the posterior tibial nerve at the level of the tarsal tunnel together with a periarterial sympathectomy on both sides, led to rapid recovery. At the same operation, a skin graft was used to cover the skin defect with excellent results in ten days. Ten months later healing remains complete.

Foot Diseases↗
PubMed1976

Ten free flap transfers: use of intra-arterial dye injection to outline a flap exactly.

Ten free skin flap transfers, with microvascular anastomose, were performed by our service since July 4, 1973. The donor site most frequently used for this purpose was the groin flap. In one case a free auxillary flap based on the external mammary artery was used. We discuss the advantages of using an intra-arterial injection of patent-blue dye to outline the maximal area supplied by the donor site vessels.

Adult↗