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A de Coster

Publications and source records attributed to A de Coster.

18 recordsLinked to original sources
PubMed1982

Site of action of inhaled histamine in asymptomatic asthmatic patients.

Histamine inhalation provocation-tests were performed in twenty-two young asthmatics with normal lung-function tests with progressive, increasing doses of a pressurized aerosol of histamine phosphate. Airway resistances (Raw) and N2 washout-curves were recorded. Two different types of response have been observed: (1) in thirteen cases, there was an increase of both Raw and the N2 phase III slope; and (2) in eight cases, there was only an increase in Raw (in one subject there was an increase in the N2 phase III slope only). Comparing the two groups of patients there was no difference in the inhalation procedure, the dose of histamine delivered or the smoking habits and lung-function data, except a slightly higher residual volume/total lung capacity (RV/TLC) ratio in the first group. The histamine-induced changes could not be related to any of the control lung-function data. We conclude that histamine inhalation may induce either peripheral bronchoconstriction only, or central bronchoconstriction with or without peripheral bronchoconstriction. A local and/or peripheral vagal-mediated bronchoconstrictor effect could account for the different site of airway response.

Adult↗
PubMed1975

Pulmonary function in metastatic carcinoma to the lung.

Pulmonary function tests, at rest and during exercise, were performed in nine patients with metastatic carcinoma to the lung. The results are compared to the usual characteristics of diffuse interstitial fibrosis. Differences also occur between the pure multiple metastases pattern and the lymphangitic one. Literature on this topic is reviewed.

Adult↗
PubMedDate not supplied

Pulmonary mechanics in diffuse fibrosing alveolitis.

The mechanical and the diffusing lung properties have been measured in 19 cases of diffuse fibrosing alveolitis of unknown etiology (proved by histology in 17 cases). The characteristic findings are: a) a striking reduction of DLCO in all the cases; b) a marked reduction of the static and dynamic compliance, in correlation with the reduction of vital capacity; c) an increase in P1max in correlation with the decrease of FRC; d) an increase of the elastic recoil when it is considered at various percentages of the predicted lung volume, but in some cases a normal shape of the V-P curve if the measured lung volume is taken into account; e) a reduction of the maximum expiratory flows suggesting bronchiolar stenosis; f) alterations of DL more marked than those of CL suggesting that DL is a more sensitive test.

Adult↗